Coagulation Pathways, Hemostasis, and Thrombosis in Liver Failure.

Abstract:

:Achieving hemostasis, preventing and treating thrombosis, and laboratory measurement of the hemostatic pathways constitute the core elements of managing the critically ill patient with liver failure. Uncontrolled bleeding in acutely decompensated cirrhosis and acute-on-chronic liver failure is probably the most familiar clinical challenge to intensivists. Bleeding in these patients can be broadly divided into pressure-driven (portal hypertension-related) bleeding with only limited dependence on hemostatic pathways and intractable mucosal/wound bleeding, which is much more directly related to a severely disturbed hemostatic system with imbalances in the coagulation cascade and the fibrinolytic system. Both types of bleeding can occur simultaneously and may even coexist with inappropriate thrombosis such as portal vein thrombosis or venous thromboembolism. Due to the fundamental role of the liver in coagulation factor synthesis and its direct and indirect regulation of nearly all aspects of the hemostatic system, laboratory measurements of coagulation pathways also constitute key aspects of all prognostic scores that guide clinical decisions and forecast optimal interventions in both acute and chronic forms of liver failure.

authors

Intagliata NM,Davis JPE,Caldwell SH

doi

10.1055/s-0038-1673658

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

598-608

issue

5

eissn

1069-3424

issn

1098-9048

journal_volume

39

pub_type

杂志文章,评审
  • Too Much Oxygen: Hyperoxia and Oxygen Management in Mechanically Ventilated Patients.

    abstract::Hyperoxia, or excess oxygen supplementation, prevails in the intensive care unit (ICU) without a beneficial effect and, in some instances, may cause harm. Recent interest and surge in clinical studies in mechanically ventilated critically ill patients has brought this to the attention of clinicians and researchers. Hy...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1570359

    authors: Pannu SR

    更新日期:2016-02-01 00:00:00

  • Pleural effusions from congestive heart failure.

    abstract::In heart failure (HF), pleural effusion results from increased interstitial fluid in the lung due to elevated pulmonary capillary pressure. Rarely, pleural effusions may occur in association with isolated right HF. HF-associated effusions are typically bilateral, but if unilateral, they are more commonly seen on the r...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0030-1269828

    authors: Porcel JM

    更新日期:2010-12-01 00:00:00

  • Organ dysfunction: general approach, epidemiology, and organ failure scores.

    abstract::Multiorgan dysfunction syndrome represents a continuum of cumulative organ dysfunction from very mildly altered function to total and, rarely, irreversible organ failure and is the major cause of death in the intensive care unit (ICU). The terms multiple organ failure syndrome (MOFS), multiple organ system failure (MO...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0031-1287862

    authors: Ferreira AM,Sakr Y

    更新日期:2011-10-01 00:00:00

  • The microbiome and emerging pathogens in cystic fibrosis and non-cystic fibrosis bronchiectasis.

    abstract::Chronic pulmonary sepsis is the predominant cause of morbidity for patients with cystic fibrosis (CF) and non-CF bronchiectasis. Previously it was thought that respiratory infection in these patients was mostly limited to a very small number of typical pathogens; however, in recent years there have been increasing rep...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1546752

    authors: Green H,Jones AM

    更新日期:2015-04-01 00:00:00

  • Ventilator-associated lung injury during assisted mechanical ventilation.

    abstract::Assisted mechanical ventilation (MV) may be a favorable alternative to controlled MV at the early phase of acute respiratory distress syndrome (ARDS), since it requires less sedation, no paralysis and is associated with less hemodynamic deterioration, better distal organ perfusion, and lung protection, thus reducing t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1382153

    authors: Saddy F,Sutherasan Y,Rocco PR,Pelosi P

    更新日期:2014-08-01 00:00:00

  • Pulmonary involvement in Sjögren syndrome.

    abstract::Sjögren syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic inflammation of exocrine glands and a variety of extraglandular sites. Lung involvement as defined by symptoms and either pulmonary function testing or radiographic abnormalities occurs in approximately 10 to 20% of patients. Subclinica...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1371529

    authors: Kreider M,Highland K

    更新日期:2014-04-01 00:00:00

  • Lymphocytic interstitial pneumonia and other benign lymphoid disorders.

    abstract::Nonneoplastic pulmonary lymphoid disorders consist of a complex spectrum of diseases for pathologists and pulmonologists alike. Advances in our understanding of these disorders in recent years have led to revisions in the classification scheme. This review summarizes the clinicoradiological and pathological features o...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1325156

    authors: Tian X,Yi ES,Ryu JH

    更新日期:2012-10-01 00:00:00

  • Pulmonary rehabilitation: an historical perspective.

    abstract::Pulmonary rehabilitation is a standard of care for patients with chronic lung disease. Through appropriate patient selection and assessment, exercise training, educational and psychosocial intervention, nutritional counseling, and breathing retraining, many benefits (e.g., reduction in level of dyspnea, improvement in...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.1055/s-0029-1242632

    authors: Carlin BW

    更新日期:2009-12-01 00:00:00

  • Adult Care in Cystic Fibrosis.

    abstract::Cystic fibrosis (CF) is now more common in adults than children in countries with well-developed health care systems. The number of adults continues to increase and will further increase if the new cystic fibrosis transmembrane conductance regulator (CFTR) modulators are disease modifying. Most of the complex morbidit...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3400289

    authors: Elborn JS

    更新日期:2019-12-01 00:00:00

  • Non-genetic influences on cystic fibrosis lung disease: the role of sociodemographic characteristics, environmental exposures, and healthcare interventions.

    abstract::Patients with cystic fibrosis (CF) exhibit significant variability in the course and severity of the disease, and this variability is best interpreted in the context of an interaction between genetic and nongenetic determinants. While a small number of patients with "mild" mutations in the CF transmembrane conductance...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2004-815660

    authors: Schechter MS

    更新日期:2003-12-01 00:00:00

  • Partial liquid ventilation.

    abstract::Mortality from the adult respiratory distress syndrome (ARDS) and the infant respiratory distress syndrome remains high despite numerous interventions and modalities. Perfluorocarbons (PFC) are inert liquids that can dissolve large amounts of oxygen and carbon dioxide and can be used as respiratory media. Partial liqu...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2000-9852

    authors: Hadjiliadis D

    更新日期:2000-01-01 00:00:00

  • Screening for lung cancer in high-risk groups: current status of low-dose spiral CT scanning and sputum markers.

    abstract::Lung cancer is the number one cause of death from cancer in the United States. Currently, there is no official recommendation to screen for lung cancer even in high-risk populations. Accordingly, we wait for patients to present with symptoms. Only 15-20% of patients are stage I lung cancer at diagnosis. Past screening...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2000-9402

    authors: Jett JR

    更新日期:2000-01-01 00:00:00

  • Organ procurement--strategies to optimize donor availability.

    abstract::Increasing donor availability for organ transplantation requires attention to factors that are potentially modifiable. The potential pool of available organs can theoretically be enlarged by considering new sources of organs, including non-beating heart donors, live donor lobar transplants, xenotransplants, and in vit...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2001-18426

    authors: Williams TJ,Snell GI

    更新日期:2001-10-01 00:00:00

  • Computed tomographic scanning in sarcoidosis.

    abstract::Sarcoidosis is a granulomatous disease of unknown etiology that involves the lungs or intrathoracic lymph nodes in more than 90% of patients. The clinical spectrum of sarcoidosis is protean, but pulmonary manifestations often dominate. Chest radiographs are abnormal in 90 to 95% of patients with sarcoidosis; the most ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2003-42375

    authors: Lynch JP 3rd

    更新日期:2003-08-01 00:00:00

  • Beta2-agonists: friend or foe?

    abstract::This review summarizes the effects of beta2-agonists on asthma severity. There has been a controversy as to whether the regularly scheduled use of beta2-adrenergic agonists increases the risk of adverse outcomes in asthma. A number of epidemiological and clinical studies have found an association between the regularly...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2002-34332

    authors: Ford JG,Iqbal J,Sunmonu Y

    更新日期:2002-08-01 00:00:00

  • Scedosporium/Pseudallescheria infections.

    abstract::The genus Scedosporium comprises a group of filamentous fungi found ubiquitously in the environment. The two major human pathogens within this genus are S. apiospermum-the asexual state of Pseudallescheria boydii-and S. prolificans. Both histologically resemble Aspergillus species, with hyphae that are septated and br...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2004-824901

    authors: Panackal AA,Marr KA

    更新日期:2004-04-01 00:00:00

  • Exposure-related diffuse lung disease.

    abstract::Practicing pulmonologists are often faced with the question of whether a lung disease is related to something in the patient's workplace, home, or recreational environment. Recognizing a lung disease as exposure related creates both opportunities and obligations for clinicians. In addition to managing the patient, the...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0028-1101272

    authors: Rose CS,Lynch DA,Cool CD

    更新日期:2008-12-01 00:00:00

  • Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review.

    abstract::In endemic areas, dimorphic fungal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides posadasii/immitis account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnos...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0040-1702194

    authors: Azar MM,Malo J,Hage CA

    更新日期:2020-08-01 00:00:00

  • Diagnosis of nontuberculous mycobacterial infections.

    abstract::The nontuberculous mycobacteria (NTM) are typically environmental organisms residing in soil and water. Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequent, followed by lymphadenitis in children, skin disease by M. marinum (particularly...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1333569

    authors: van Ingen J

    更新日期:2013-02-01 00:00:00

  • A Practical Approach to Clinical Antibiotic Stewardship in the ICU Patient with Severe Infection.

    abstract::Patients with severe infections are often treated with multiple courses of antibiotics in the intensive care unit (ICU), making the ICU a true antibiotic hotspot. The increasing incidence of multidrug resistance worldwide emphasizes the need for continued efforts in developing and implementing antibiotic stewardship p...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1693995

    authors: Fierens J,Depuydt PO,De Waele JJ

    更新日期:2019-08-01 00:00:00

  • Current challenges in pediatric pulmonary hypertension.

    abstract::Pulmonary arterial hypertension (PAH) in the pediatric population is associated with a variety of underlying diseases and causes, significantly morbidity and mortality. In the majority of patients, PAH in children is idiopathic or associated with congenital heart disease (CHD), with pulmonary hypertension (PH) associa...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1356461

    authors: Takatsuki S,Ivy DD

    更新日期:2013-10-01 00:00:00

  • Selected controversies in cardiopulmonary resuscitation.

    abstract::Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics, emergency department personnel, and inpatient physicians. Unfortunately, after more than 40 years of practice and study, there are still many controversies and unresolved treatment issues. This article focuses on four current controversies in C...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2001-13839

    authors: White SJ,Himes D,Rouhani M,Slovis CM

    更新日期:2001-01-01 00:00:00

  • Clinical trial design in acute lung injury--issues and controversies.

    abstract::The evolution of scientific investigation in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is replete with examples of effective bench-to-bedside transitions, pioneering research methodology, and international collaboration. This article highlights for clinicians a selection of challenges and ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0033-1351120

    authors: Meade MO,Lamontagne F

    更新日期:2013-08-01 00:00:00

  • Pandemic (avian) influenza.

    abstract::Pandemics of influenza have been reported since the early sixteenth century. Recent pandemics include the Spanish flu (H1N1) from 1918 to 1920 (resulting in approximately 50 million deaths worldwide); the Asian flu (H2N2) from 1957 to 1958 (resulting in more than 1 million deaths); the Hong Kong flu (H3N2) from 1968 t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-976488

    authors: Rajagopal S,Treanor J

    更新日期:2007-04-01 00:00:00

  • Current Controversies in Sepsis Management.

    abstract::The overarching goals of early sepsis management include early recognition, appropriate antibiotic therapy and source control, maintenance of hemodynamic stability, and supportive care of organ dysfunction. Despite increasing awareness of the global burden of sepsis, and general agreement on the goals of management, t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1696981

    authors: Moss SR,Prescott HC

    更新日期:2019-10-01 00:00:00

  • Reversal of Oral Anticoagulants for Intracerebral Hemorrhage Patients: Best Strategies.

    abstract::In patients with acute intracerebral hemorrhage (ICH), one of the major concerns is ongoing bleeding or ICH expansion. Anticoagulated patients are at higher risk of ongoing expansion and worse outcome. It may be that rapid anticoagulation reversal can reduce the risk of expansion and improve clinical outcome. For thos...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1607993

    authors: Fuh L,Sin JH,Goldstein JN,Hayes BD

    更新日期:2017-12-01 00:00:00

  • Epidemiology of chronic bronchitis and acute infective exacerbations of chronic bronchitis.

    abstract::Acute exacerbations of chronic bronchitis (AECBs) are one of the major causes of morbidity and mortality in the United States, resulting in significant cost to the health care system. Epidemiological information on chronic bronchitis is abundant and has been collected in most industrialized countries. The epidemiology...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2000-9845

    authors: Kim N,Leeper KV Jr

    更新日期:2000-01-01 00:00:00

  • Hematologic failure.

    abstract::Hematologic factors, in particular platelets and the coagulation system, play an important role in the pathogenesis of organ failure in the intensive care unit. Failure of these hematologic systems is common in intensive care patients and may range from isolated thrombocytopenia or prolonged global clotting tests to c...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1287873

    authors: Levi M,Schultz M

    更新日期:2011-10-01 00:00:00

  • Treatment of advanced non-small cell lung cancer in the elderly.

    abstract::Non-small cell lung cancer (NSCLC) is primarily a disease of the elderly. Although NSCLC is the leading cause of cancer death in the United States and the overall prognosis of this disease is poor, treatment improves survival compared with best supportive care, independent of the stage of disease. Elderly patients hav...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-871987

    authors: Sequist LV,Fidias P

    更新日期:2005-06-01 00:00:00

  • Oropharyngeal Decontamination with Antiseptics to Prevent Ventilator-Associated Pneumonia: Rethinking the Benefits of Chlorhexidine.

    abstract::Daily oral care with chlorhexidine for mechanically ventilated patients is ubiquitous in contemporary intensive care practice. The practice is predicated upon meta-analyses suggesting that adding chlorhexidine to daily oral care regimens can reduce ventilator-associated pneumonia (VAP) rates by up to 40%. Close analys...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1602584

    authors: Klompas M

    更新日期:2017-06-01 00:00:00