Abstract：
:This study examined the relation between femoral artery hyperemic responses to leg exercise and microvascular oxygen extraction in nine young [(mean +/- S.E.M) Y: 25 +/- 1 years] and 13 older (O: 67 +/- 1 years) healthy women. Femoral artery blood flow (FBF; Doppler ultrasound), mean arterial pressure (MAP), and femoral vascular conductance (FVC; FBF/MAP) were assessed at rest and during 9 min of approximately 17-18 W single knee extensor exercise. Near-infrared spectroscopy (NIRS) in the vastus lateralis was used to measure changes in deoxyhemoglobin (HHb) and oxyhemoglobin (O(2)Hb) to assess oxygen extraction (Delta HHb), microvascular blood volume (Delta HHb + O(2)Hb), and spatial heterogeneity of blood volume (relative dispersion, defined as the coefficient of variation of measurements from all NIR sensors). During exercise, FBF and FVC were lower (p < 0.05) in O compared to Y (Y: 1,430 +/- 101 mL min(-1) and 16.6 +/- 1.2 mL min(-1) per mmHg versus O: 1,127 +/- 64 mL min(-1) and 10.9 +/- 0.6 mL min(-1)per mmHg). While oxygen extraction increased more rapidly in Y, there were no age differences (p > 0.10) beyond the fourth min of exercise. In addition, the relative increase in microvascular blood volume was not significantly different during exercise in Y versus O (age effect: p = 0.87), although Y demonstrated an increase in blood volume heterogeneity in both the active and inactive leg (p = 0.02 and <0.05, respectively) not observed in O (p = 0.71 and 0.28, respectively). NIRS-derived measurements of changes in deoxygenated hemoglobin do not support the hypothesis that older women compensate for the blunted leg hyperemic response to knee extensor exercise through an augmentation of quadriceps oxygen extraction; knee extensor work may be accomplished by other metabolic or microvascular adjustments to exercise in older women.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Parker BA,Smithmyer SL,Ridout SJ,Ray CA,Proctor DNdoi
10.1007/s00421-008-0711-0subject
Has Abstractpub_date
2008-06-01 00:00:00pages
343-51issue
3eissn
1439-6319issn
1439-6327journal_volume
103pub_type
杂志文章abstract：:A plateau in oxygen consumption (VO(2)) has long been considered the criterion for maximal effort during an incremental exercise test. But, surprisingly, the termination of a maximum exercise test often occurs in the absence of a VO(2) plateau. To explain this inconsistency, some have proposed that an oxygen limitatio...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2014-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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journal_title：European journal of applied physiology
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更新日期：2009-01-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-007-0616-3
更新日期：2008-09-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0567-8
更新日期：2007-12-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3706-x
更新日期：2017-11-01 00:00:00
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