Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.

Abstract:

AIM:To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model. METHODS:Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-alpha, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS:We observed a significantly reduced incidence of bacterial translocation to the liver, spleen, mesenteric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid- treated rats (16.11 +/- 2.46 vs 32.97 +/- 3.91, P < 0.01). CONCLUSION:Melatonin has a protective effect on bacterial translocation and apoptosis.

journal_name

World J Gastroenterol

authors

Akcan A,Kucuk C,Sozuer E,Esel D,Akyildiz H,Akgun H,Muhtaroglu S,Aritas Y

doi

10.3748/wjg.14.918

subject

Has Abstract

pub_date

2008-02-14 00:00:00

pages

918-24

issue

6

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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