Abstract:
:Endoneurial capillaries in nerve biopsies from 12 adult diabetic cats with varying degrees of neurological dysfunction were examined for evidence of microvascular pathology and compared to nerves obtained at necropsy from 7 adult non-diabetic cats without clinical evidence of neurological dysfunction. As reported previously [Mizisin, A.P., Nelson, R.W., Sturges, B.K., Vernau, K.M., LeCouteur, R.A., Williams, D.C., Burgers, M.L., Shelton, G.D., 2007. Comparable myelinated nerve pathology in feline and human diabetes mellitus. Acta Neuropathol. 113, 431-442.], the diabetic cats had elevated glycosylated hemoglobin and serum fructosamine levels, decreased motor nerve conduction velocity and compound muscle action potential (CMAP) amplitude, and markedly decreased myelinated nerve fiber densities. Compared to non-diabetic cats, there was a non-significant 26% increase in capillary density and a significant (P<0.009) 45% increase in capillary size in diabetic cats. Capillary luminal size was also significantly (P<0.001) increased, while an index of vasoconstriction was significantly decreased (P<0.001) in diabetic cats compared to non-diabetic controls. No differences in endothelial cell size, endothelial cell number or pericyte size were detected between non-diabetic and diabetic cats. In diabetic cats, basement membrane thickening, seen as a reduplication of the basal lamina, was significantly (P<0.0002) increased by 73% compared to non-diabetic controls. Regression analysis of either myelinated nerve fiber density or CMAP amplitude against basement membrane size demonstrated a negative correlation with significant slopes (P<0.03 and P<0.04, respectively). These data demonstrate that myelinated nerve fiber injury in feline diabetic neuropathy is associated with microvascular pathology and that some of these changes parallel those documented in experimental rodent and human diabetic neuropathy.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Estrella JS,Nelson RN,Sturges BK,Vernau KM,Williams DC,LeCouteur RA,Shelton GD,Mizisin APdoi
10.1016/j.mvr.2007.12.002subject
Has Abstractpub_date
2008-04-01 00:00:00pages
403-10issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(07)00156-2journal_volume
75pub_type
杂志文章abstract::Cardiovascular diseases, among all diseases, are taking the most victims worldwide. Coronary artery occlusion, takes responsibility of about 30% of the yearly global deaths in the world (Heart Disease and Stroke Statistics 2017 At-a-Glance, 2017), raising the need for viable substitutes for cardiovascular tissues. Dep...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2020.104027
更新日期:2020-09-01 00:00:00
abstract::To compute two parameters of capillary protein transport of reflection coefficient (sigma) and permeability--surface area product (PS), two major methods have been employed. The first, or crosspoint method, uses two sets of lymph flow (Jv) and lymph/plasma protein concentration ratios (R) and solves the irreversible t...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(85)90051-2
更新日期:1985-09-01 00:00:00
abstract::Leukocyte margination in the vessels of the microcirculation has been attributed to a flow-dependent interaction with red cells. To determine the extent of this effect, experiments with human blood were done in 100- to 180-micron tubes to detect changes in cell distribution as a function of hematocrit and flow rate. U...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(84)90054-2
更新日期:1984-03-01 00:00:00
abstract::Diabetic retinopathy (DR) is a disease that causes blindness due to vascular leakage or abnormal angiogenesis. Hepatocyte growth factor (HGF) is increased in the serum or vitreous fluid in proliferative diabetic retinopathy (PDR) patients, although the effect of HGF on the blood vessels remains unclear. This study foc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104103
更新日期:2021-01-01 00:00:00
abstract::Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix (ECM) are of central importance to vascular growth. Here, we present a new model of EC migration and morphogenesis within three-dimensional ECM termed "radial invasion of matrix by aggregated cells" (RIMAC). In the RIMAC model,...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2122
更新日期:1999-03-01 00:00:00
abstract::The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and since then, a plethora of pro- and anti-angiogenic factors have been identified. In the recent years, it has become clear that angiogenesis, the formation of new capillaries from a pre-existing capillary network, is highly regulated b...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2007.05.005
更新日期:2007-09-01 00:00:00
abstract::The electrokinetically modulated peristaltic transport of power-law fluids through a narrow confinement in the form of a deformable tube is investigated. The fluid is considered to be divided into two regions - a non-Newtonian core region (described by the power-law behavior) which is surrounded by a thin wall-adherin...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::Studies of blood flow in mesentery, cremaster muscle, and small bore glass tubes were performed to obtain a relationship between mean velocity (Vmean) and red cell velocity using the two-slit method under epifluorescence (Vepi) and transillumination (Vtrans) microscopy. The velocities Vepi and Vtrans obtained in vivo ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(89)90020-4
更新日期:1989-07-01 00:00:00
abstract::Hypoxia-induced arginase elevation plays an essential role in several vascular diseases but influence of arginase on hypoxia-mediated angiogenesis is completely unknown. In this study, in vitro network formation in bovine aortic endothelial cells (BAEC) was examined after exposure to hypoxia for 24h with or without ar...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.11.002
更新日期:2015-03-01 00:00:00
abstract::The multiple pore model of T. R. Harris and R. J. Roselli (1981, J. Appl. Physiol: Respir. Environ. Exercise Physiol. 50, 1-14), was used to simulate lung lymph flow and protein transport at various levels of microvascular pressure. Response of the three-pore structure determined in that study was found to be in excel...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(85)90022-6
更新日期:1985-05-01 00:00:00
abstract::The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2002.2397
更新日期:2002-07-01 00:00:00
abstract::Endometriosis, the presence of endometrium-like tissue outside of the uterine cavity, is a common disease among women of reproductive age. Typical symptoms include abdominal pain and painful menstruation. In addition, endometriosis is associated with reduced fertility. Current treatment modalities, the surgical remova...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2007.04.008
更新日期:2007-09-01 00:00:00
abstract::Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arteriole...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.04.007
更新日期:2018-09-01 00:00:00
abstract::To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.03.004
更新日期:2004-07-01 00:00:00
abstract::Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visu...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90022-2
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103907
更新日期:2019-11-01 00:00:00
abstract::A simple model has been developed for simulation of oxygen transport to and from blood flowing in conduits of the diameter of arterioles and larger (greater than or equal to 20 microns). The basis is the large capillary model (LCAP) of P.K. Nair, et al. 1989 which has been validated experimentally. Detailed calculatio...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(90)90070-8
更新日期:1990-03-01 00:00:00
abstract::This study further investigates the mechanisms responsible for the effects of acute and severe hypoxia, and subsequent reoxygenation, on the contractility of isolated rat mesenteric arteries. In noradrenaline (NA)-contracted arteries, hypoxia caused a relaxation to near baseline levels. Reoxygenation resulted in an im...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.08.001
更新日期:2004-11-01 00:00:00
abstract::The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2163
更新日期:1999-09-01 00:00:00
abstract::Concentration-response curves are often used as indicators of vascular reactivity and receptor sensitivity. Some investigators use ethylenediaminetetraacetate (EDTA) or ascorbic acid (ASC) to prevent catecholamine oxidation but many others do not. This difference may affect estimates of reactivity. We tested the effec...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90057-2
更新日期:1983-07-01 00:00:00
abstract::An increasing body of evidence suggests that the deleterious effects of Acute Kidney Injury (AKI) on remote organ function could, at least in part, be due to loss of the normal balance of immune, inflammatory, and soluble mediator metabolism that attends injury of the tubular epithelium. Such dysregulation, acting at ...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2008.09.001
更新日期:2009-01-01 00:00:00
abstract:AIMS:The purpose of the present study was to investigate the possible role of TIPE2 on acute lung injury (ALI) induced by myocardial ischemia/reperfusion (MIR) in diabetic rats. METHODS:Sprague-Dawley (SD) rats were randomly separated into four groups: control+sham (C + sham); control+MIR (C + MIR); diabetes+sham (D +...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104009
更新日期:2020-07-01 00:00:00
abstract::A mathematical model of nonsteady-state fluid movement in the lung interstitium during hydrodynamic loading is evaluated. The model is based on experimental results obtained in isolated perfused canine lungs. The interstitium is treated as a porous phase with an elastic framework, able to relax; all resistance to flux...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(91)90071-i
更新日期:1991-07-01 00:00:00
abstract::The angiopoietin/Tie2 system is a predominant regulator of vascular development. This vascular development appears to be controlled and completed by the coordinated actions of two vascular cells, endothelial cells and their surrounding supporting cells, smooth muscle cells, or pericytes. The role of the angiopoietin/T...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/s0026-2862(02)00035-3
更新日期:2003-03-01 00:00:00
abstract::The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human pathologies have begun to reveal potential functions of VEGF in quiescent vasculature. Further ...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2007.03.004
更新日期:2007-09-01 00:00:00
abstract::Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2002.2432
更新日期:2002-09-01 00:00:00
abstract::Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. We tested the hypothesis that nitrate supplementation would augment the NO co...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.12.002
更新日期:2015-03-01 00:00:00
abstract::Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is implicated in the pathogenesis of proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. Since oxidative stress is thought t...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.11.001
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively. PATIENTS AND METHODS:40 patients undergoing hepatic resection were included and grouped according to if they were operat...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.05.002
更新日期:2014-07-01 00:00:00
abstract::Endothelial cells and endothelial progenitor cells (EPCs) play a key role in the pathogenesis of vascular disease. Both cell types are affected by the oxidative stress but their susceptibility may be different. This study aimed to investigate the antioxidative enzymes activated in EPCs after high constant glucose expo...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.05.004
更新日期:2010-12-01 00:00:00