A randomised study comparing the efficacy and safety of rosuvastatin with atorvastatin for achieving lipid goals in clinical practice in Asian patients at high risk of cardiovascular disease (DISCOVERY-Asia study).


BACKGROUND:Most studies investigating the benefits of statins have focused on North American and European populations. This study focuses on evaluating the lipid-lowering effects of rosuvastatin and atorvastatin in Asian patients. OBJECTIVES:The DIrect Statin COmparison of LDL-C Values: an Evaluation of Rosuvastatin therapY (DISCOVERY)-Asia study is one of nine independently powered studies assessing the efficacy of starting doses of statins in achieving target lipid levels in different countries worldwide. DISCOVERY-Asia was a 12-week, randomised, open-label, parallel-group study conducted in China, Hong Kong, Korea, Malaysia, Taiwan, and Thailand. RESULTS:A total of 1482 adults with primary hypercholesterolaemia and high cardiovascular risk (> 20%/10 years, type 2 diabetes, or a history of coronary heart disease) were randomised in a 2 : 1 ratio to receive rosuvastatin 10 mg once daily (o.d.) or atorvastatin 10 mg o.d. The percentage of patients achieving the 1998 European Joint Task Force low-density lipoprotein cholesterol (LDL-C) goal of < 3.0 mmol/L at 12 weeks was significantly higher in the rosuvastatin group (n = 950) compared with the atorvastatin group (n = 471) (79.5 vs. 69.4%, respectively; p < 0.0001). Similar results were observed for 1998 European goals for total cholesterol (TC), and the 2003 European goals for LDL-C and TC. LDL-C and TC levels were reduced significantly more with rosuvastatin compared with atorvastatin. Both drugs were well-tolerated and the incidence and type of adverse events were similar in each group. TRIALS REGISTRATION:The trial registry summary is available at http://www.clinicaltrials.gov/; ClinicalTrials.gov Identifier: NCT00241488 CONCLUSIONS:This 12-week study showed that the starting dose of rosuvastatin 10 mg o.d. was significantly more effective than the starting dose of natorvastatin 10 mg o.d. at enabling patients with primary hypercholesterolaemia to achieve European goals for LDL-C and TC in a largely Asian population in real-life clinical practice. The safety profile of rosuvastatin 10 mg is similar to that of atorvastatin 10 mg in the Asian population studied here, and is consistent with the known safety profile of rosuvastatin in the white population.


Curr Med Res Opin


Zhu JR,Tomlinson B,Ro YM,Sim KH,Lee YT,Sriratanasathavorn C




Has Abstract


2007-12-01 00:00:00












  • Efficacy and tolerability of twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial.

    abstract:OBJECTIVE:This trial evaluated the efficacy and safety of pregabalin dosed twice daily (BID) for relief of neuro-pathic pain associated with postherpetic neuralgia (PHN). RESEARCH DESIGN AND METHODS:The 13-week, double-blind, placebo-controlled study randomized 370 patients with PHN to pregabalin (150, 300, or 600 mg/...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验


    authors: van Seventer R,Feister HA,Young JP Jr,Stoker M,Versavel M,Rigaudy L

    更新日期:2006-02-01 00:00:00

  • Metabolic studies with 'Nutrauxil', an enteral feed preparation.

    abstract::A metabolic study was carried out in 6 patients requiring enteral feeding to investigate the effectiveness and tolerance of 'Nutrauxil', a ready-made liquid nutritional preparation, over a period of 8 days. The results of anthropometric and laboratory measurements, made initially and at the end of two 4-day periods, s...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Lee HA,Talbot S,Patil R,Jackson JM,Holland D

    更新日期:1983-01-01 00:00:00

  • Balancing efficacy and tolerability of prostaglandin analogues and prostaglandin-timolol fixed combinations in primary open-angle glaucoma.

    abstract:BACKGROUND:Lowering intraocular pressure (IOP) is currently the only therapeutic approach that preserves visual function in primary open-angle glaucoma. In making treatment decisions for first- and second-line therapy, the clinician needs to provide an appropriate balance of efficacy and tolerability. Prostaglandin ana...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Aptel F,Denis P

    更新日期:2011-10-01 00:00:00

  • Pharmacological agents used for the treatment of stress urinary incontinence in women.

    abstract::Stress urinary incontinence (SUI) is the involuntary loss of urine associated with physical activities such as running, jumping, or lifting, or with sneezing and coughing. For many patients it can be a very bothersome symptom, causing social isolation, loss of self-esteem, and increased expenses. Although there is cur...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Viktrup L,Bump RC

    更新日期:2003-01-01 00:00:00

  • The prevalence, correlates and treatment of pain in the European Union.

    abstract:OBJECTIVES:To report on the results of a recent large-scale, internet-based survey of the population, prevalence and attributes of pain experience in the United Kingdom (UK), France, Spain, Germany and Italy. METHODS:The results reported here are taken from the internet-based, 2008 National Health and Wellness Survey ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Langley PC

    更新日期:2011-02-01 00:00:00

  • Critical thinking about three meta-analyses: can vitamin D alone or with calcium prevent fractures?

    abstract::Critical thinking is crucially important in both research and practice. This article demonstrates that a lack of critical thinking in two meta-analyses resulted in a conclusion that contradicts another meta-analysis and popular opinions. Kahwati et al. and Zhao et al. drew a conclusion that "Vitamin D supplementation ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Fan H,Xiao J

    更新日期:2020-03-01 00:00:00

  • Six-day clotrimazole therapy in vaginal candidosis.

    abstract::Two hundred and two patients with symptoms, signs and mycological evidence of Candida vaginitis were entered in a single-blind trial comparing 6-day clotrimazole therapy with a control group receiving 6 days' nystatin therapy. Adequate data was collected on 69 clotrimazole and 72 nystatin treated patients for analysis...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Masterton G,Henderson J,Napier IR,Moffet M

    更新日期:1975-01-01 00:00:00

  • Cost-effectiveness of switching to insulin degludec from other basal insulins: evidence from Swedish real-world data.

    abstract:OBJECTIVES:Health economic analysis from a healthcare and societal point of view was conducted to assess the cost-effectiveness of insulin degludec (IDeg) after switching from other basal insulins in people with type 1 diabetes. MATERIAL AND METHODS:This was a prospective, open-label, single arm, observational follow-...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Landstedt-Hallin L,Gundgaard J,Ericsson Å,Ellfors-Zetterlund S

    更新日期:2017-04-01 00:00:00

  • Occurrence of adverse events among patients with inflammatory bowel disease in the HealthCore Integrated Research Database.

    abstract:OBJECTIVES:Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse events (AEs). The objectives of this study were to assess ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: McAuliffe ME,Lanes S,Leach T,Parikh A,Faich G,Porter J,Holick C,Esposito D,Zhao Y,Fox I

    更新日期:2015-01-01 00:00:00

  • Overactive bladder in women: symptom impact and treatment expectations.

    abstract:OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: MacDiarmid S,Rosenberg M

    更新日期:2005-09-01 00:00:00

  • Initiative for a new diabetes therapeutic approach in a Mediterranean country: the INDEED study.

    abstract:AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Athyros VG,Hatzitolios A,Karagiannis A,Didangelos TP,Iliadis F,Dolgyras S,Vosnakidis T,Vasiliadis P,Malias I,Tziomalos K,Samouilidou M,Mikhailidis DP,INDEED Collaborative Group.

    更新日期:2009-08-01 00:00:00

  • Daily fluctuations in the plasma cortisol level of children with rheumatoid arthritis before and after treatment with tetracosactrin ('Cortrosyn Depot') and corticosteroid hormones.

    abstract::Daily fluctuations in plasma cortisol levels were studied in three groups of children with rheumatoid arthritis. One group was untreated with hormones, the second treated with a depot preparation of tetracosactrin, and the third group with corticosteroid hormones. The results obtained were compared with the rhythm in ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Tsvetkova V

    更新日期:1977-01-01 00:00:00

  • Prefilled insulin device with reduced injection force: patient perception and accuracy.

    abstract:OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Pfützner A,Reimer T,Hohberg C,Frøkjaer LP,Jørgensen C

    更新日期:2008-09-01 00:00:00

  • Betahistine plus piracetam dual therapy versus betahistine monotherapy for peripheral vestibular vertigo: a confounder-corrected subanalysis of the OSVaLD study.

    abstract:INTRODUCTION:This subanalysis compared the efficacy of betahistine plus piracetam dual therapy versus betahistine monotherapy using data from OSVaLD, a 3 month, open-label, observational study conducted in 2272 patients with peripheral vestibular vertigo. Of the 1898 patients included in the original efficacy populatio...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Melnikov OA,Lilenko SV,Nauta J,Ouwens MJ

    更新日期:2015-11-01 00:00:00

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    abstract::The results of a series of studies on body fluid, electrolytes and diuretics are discussed. The findings to date indicate that the sex difference between mean potassium plasma levels in men and women is preserved into old age. Contrary to previous suggestions, there would appear to be no transient self-correcting hypo...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: McCarthy ST

    更新日期:1982-01-01 00:00:00

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    abstract:OBJECTIVE:To investigate whether once daily biphasic insulin aspart 30 (BIAsp 30) is noninferior to once daily insulin glargine (IGlar) among Chinese and Japanese insulin-naïve subjects with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS:This was a 24 week treat-to-target trial (NCT01123980) that include...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yang W,Xu X,Liu X,Yang G,Seino Y,Andersen H,Jinnouchi H

    更新日期:2013-12-01 00:00:00

  • The role of angiotensin antagonism in stroke prevention in patients with hypertension: focus on losartan.

    abstract::Optimal management of hypertension has been shown to reduce the risk of stroke. In recent years, newer classes of antihypertensive such as the angiotensin II (Ang II) antagonists have become available. Results from the Losartan Intervention for Endpoint reduction in hypertension (LIFE) study suggest the utility of thi...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Ferrario CM

    更新日期:2004-11-01 00:00:00

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    journal_title:Current medical research and opinion

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    authors: Woolley KL,Lew RA,Stretton S,Ely JA,Bramich NJ,Keys JR,Monk JA,Woolley MJ

    更新日期:2011-06-01 00:00:00

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    abstract::Venous thromboembolism (VTE) is a major cause of morbidity and mortality and is associated with substantial healthcare costs. Identification of patients at risk of developing VTE enables appropriate thromboprophylaxis to be implemented. Although no predisposing risk factors can be identified in many patients in whom V...

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    authors: Shirvanian S,Tapson VF

    更新日期:2015-12-01 00:00:00

  • Systematic review of reports describing potential impact of the Sunshine Act on peer-reviewed medical publications.

    abstract:OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Toroser D,Robinson M,Gegner J,Smith G,Nilsen J,Hyatt L,Johnson T,Hassan A,Gatchalian C

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    abstract:OBJECTIVES:The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy for their psychiatric disorder. RESEARCH DESIGN AND METHO...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Winner JG,Carhart JM,Altar CA,Goldfarb S,Allen JD,Lavezzari G,Parsons KK,Marshak AG,Garavaglia S,Dechairo BM

    更新日期:2015-01-01 00:00:00

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    abstract::The effects of flurbiprofen on various coagulation and haemostasis parameters were studied in 19 patients adequately anticoagulated on a fixed dose of phenprocoumon. Laboratory controls were performed 5 times at weekly intervals. Flurbiprofen 50 mg 3-times daily was given for 2 weeks after an initial control period of...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Marbet GA,Duckert F,Walter M,Six P,Airenne H

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  • Colesevelam in the treatment of hypercholesterolemia and hyperglycemia: a retrospective analysis from an ambulatory care medical network.

    abstract:OBJECTIVE:To examine outcomes associated with colesevelam treatment among patients with hypercholesterolemia in real-world clinical practice. METHODS:This analysis was conducted as a retrospective, observational cohort study in an ambulatory-care medical network in Northern California. Patients with orders for colesev...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Romanelli RJ,Leahy A,Jukes T,Ye X,Qian C,Ishisaka DY

    更新日期:2013-12-01 00:00:00

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    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Agozzino M,Russo T,Franceschini C,Mazzilli S,Garofalo V,Campione E,Bianchi L,Milani M,Argenziano G

    更新日期:2019-10-01 00:00:00

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    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验


    authors: Elshoff JP,Bauer L,Goldammer N,Oortgiesen M,Pesch H,Timmermann L

    更新日期:2018-07-01 00:00:00

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    abstract:MOTIVATION:The American Society of Parenteral and Enteral Nutrition (ASPEN) guidelines advise use of enteral nutrition (EN) for critically ill hospital patients requiring nutritional support, but no studies have comprehensively estimated economic benefits from adherence to this recommendation. METHODS:We systematicall...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析,评审


    authors: Cangelosi MJ,Auerbach HR,Cohen JT

    更新日期:2011-02-01 00:00:00

  • Cost-effectiveness of statin therapy for vascular event prevention in adults with elevated C-reactive protein: implications of JUPITER.

    abstract:OBJECTIVES:High-sensitivity C-reactive protein (hs-CRP) has been explored for use in predicting cardiovascular risk. The recent Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) study found that statin therapy reduced cardiovascular events in those with ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Slejko JF,Page RL 2nd,Sullivan PW

    更新日期:2010-10-01 00:00:00

  • Lipid-lowering effects of colesevelam HCl in combination with ezetimibe.

    abstract:OBJECTIVE:The primary aim of this study was to compare the effect of colesevelam HCl in combination with ezetimibe to ezetimibe monotherapy on low-density lipoprotein cholesterol (LDL-C) levels in subjects with primary hypercholesterolemia. METHODS:Subjects with primary hypercholesterolemia (N = 86) were enrolled in a...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bays H,Rhyne J,Abby S,Lai YL,Jones M

    更新日期:2006-11-01 00:00:00

  • Enteric-coated budesonide for the induction and maintenance of remission of Crohn's disease in children.

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    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Cohen SA,Aloi M,Arumugam R,Baker R,Bax K,Kierkuś J,Koletzko S,Lionetti P,Persson T,Eklund S

    更新日期:2017-07-01 00:00:00

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    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,meta分析


    authors: Woodman G,Cywes R,Billy H,Montgomery K,Cornell C,Okerson T,APEX Study Group.

    更新日期:2012-04-01 00:00:00