Comparison of temazepam 7.5 mg with temazepam 15 mg for the treatment of transient insomnia.

abstract：OBJECTIVE:Vildagliptin is a potent and selective dipeptidyl peptidase-IV (DPP-4) inhibitor that improves glycemic control in patients with type 2 diabetes by increasing alpha and beta-cell responsiveness to glucose. This study assessed the effect of multiple doses of vildagliptin 100 mg once daily on warfarin pharmacok...

journal_title：Current medical research and opinion

authors： He YL,Sabo R,Riviere GJ,Sunkara G,Leon S,Ligueros-Saylan M,Rosenberg M,Dole WP,Howard D

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Ocular surface disease (OSD) is a common side effect of ophthalmic medications containing the preservative benzalkonium chloride (BAK). Little is known whether and how glaucoma treatment patterns and annual costs vary based on the presence of BAK. The objective of this analysis was to estimate first-year trea...

journal_title：Current medical research and opinion

authors： Schmier JK,Covert DW,Robin AL

更新日期：2010-12-01 00:00:00

abstract：:Objectives: Ethics guidelines such as the Declaration of Helsinki and the CIOMS International Ethical Guidelines for Health-related Research Involving Humans require the sponsors, in cooperation with relevant stakeholders, to provide post-trial access (PTA) to intervention and knowledge, especially in clinical trials ...

journal_title：Current medical research and opinion

authors： Jimenez EB,Virtudazo JMP,Torres CE,Bernabe RD

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...

journal_title：Current medical research and opinion

authors： Kaatz S,Coleman CI,Bookhart B,Laliberté F,Nelson WW,Brown K,Martin S,Schein J,Lefebvre P

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Inadequate treatment by non-specialty primary care physicians (PCPs) has been a concern in improving osteoporosis care. An increase in outpatient visits by older patients seeking osteoporosis care has been reported. But what percentages of these visits are made to PCPs are unknown. We investigated recent tre...

journal_title：Current medical research and opinion

authors： Rianon N,Anand D,Rasu R

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To analyse the significance of 'onset of effect' on clinical outcome in the treatment of depression and the contribution of individual Montgomery-Asberg Depression Rating Scale (MADRS) items to improvements in the MADRS total score. RESEARCH DESIGN AND METHOD:All five published placebo-controlled clinical st...

journal_title：Current medical research and opinion

authors： Wade A,Friis Andersen H

更新日期：2006-11-01 00:00:00

abstract：:Objective: Type 2 diabetes (T2D) is a prevalent health problem. Oral agents, with the exception of metformin, are often discontinued with the initiation of insulin. The objective was to understand the proportion of patients discontinuing dipeptidyl peptidase-4 inhibitors (DPP-4is) and the reasons for the decision to d...

journal_title：Current medical research and opinion

authors： Fernandes G,Matos JE,Jaffe DH,Beyer G,Yang L,Iglay K,Gantz I,Rajpathak S

更新日期：2020-03-01 00:00:00

abstract：:A clinical evaluation was carried out in 19 patients with lichen ruber planus to assess the effectiveness of 0.05% betamethasone-17,21-dipropionate ointment in the treatment of patients whose lesions had developed resistance to prolonged treatment with 0.1% betamethasone-17-valerate ointment. The new steroid ointment ...

journal_title：Current medical research and opinion

authors： Björnberg A,Hellgren L

更新日期：1976-01-01 00:00:00

abstract：:Anaemia is an important factor in the fatigue experienced by many patients receiving chemotherapy. A recent large-scale, randomised, placebo-controlled trial has shown that treatment with epoetin alfa raises haemoglobin levels, reduces fatigue and improves overall quality of life (QoL). In order to examine the relatio...

journal_title：Current medical research and opinion

authors：

更新日期：2005-01-01 00:00:00

abstract：:Objective: To evaluate the safety and efficacy of fulranumab as adjunct or monotherapy in patients with knee or hip pain related to moderate-to-severe osteoarthritis.Methods: Osteoarthritic patients (aged ≥18 years) from four phase 3 randomized, double-blind (DB), placebo-controlled studies were randomized to receive ...

journal_title：Current medical research and opinion

authors： Kelly KM,Sanga P,Zaki N,Wang S,Haeussler J,Louie J,Thipphawong J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and...

journal_title：Current medical research and opinion

authors： Torun MT,Ünver E,Yalçın Y,Kanmaz L,Seçkin E

更新日期：2018-03-01 00:00:00

abstract：:An open, multi-centre trial was carried out to assess the efficacy and tolerance of acemetacin in the treatment of patients suffering from various rheumatic diseases. The patients were treated by general practitioners for a maximum period of 6 weeks with a daily dose of 60 mg acemetacin 3-times daily. Assessments were...

journal_title：Current medical research and opinion

authors： Rechziegler H,Zündorf P

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson's disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulations of rotigotine (improved room temperature-stable [PR2.3.1/Tr...

journal_title：Current medical research and opinion

authors： Elshoff JP,Bauer L,Goldammer N,Oortgiesen M,Pesch H,Timmermann L

更新日期：2018-07-01 00:00:00

abstract：:Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...

journal_title：Current medical research and opinion

authors： Balcombe NR,Ferry PG,Saweirs WM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:In contrast to the trial design of acute mania studies, there is no standard design for bipolar maintenance studies. Over the past 15 years, the design of monotherapy maintenance studies in bipolar disorder has evolved significantly, but recent study designs continue to differ in important ways. SCOPE:We re...

journal_title：Current medical research and opinion

authors： Gitlin MJ,Abulseoud O,Frye MA

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To assess the impact of the decision by Kela (The Social Insurance Institution) to adopt guidelines for the management of food allergies in children, developed by the Finnish Medical Society Duodecim, as the basis for reimbursing clinical nutrition preparations for the treatment of cow milk allergy (CMA) in F...

journal_title：Current medical research and opinion

authors： Guest JF,Valovirta E

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Eribulin mesylate (eribulin) is indicated for patients with metastatic breast cancer (MBC) who have previously received at least two chemotherapies in the US and for patients with locally advanced breast cancer (LABC) or MBC who have progressed after at least one chemotherapy in the European Union (EU). In b...

journal_title：Current medical research and opinion

authors： Chabot I,Zhao Q,Su Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To systematically identify and assess current quality measures for anticoagulation in atrial fibrillation (AF), venous thromboembolism (VTE) treatment and surgical VTE prophylaxis. RESEARCH DESIGN AND METHODS:Fifteen quality measure websites were searched as were bibliographic databases (January 2000-Februar...

journal_title：Current medical research and opinion

authors： Sobieraj DM,White CM,Parker M,Bookhart BK,Coleman CI

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Pain is usually assessed by spontaneous pain ratings. Time-dependent (brief attacks) or evoked (allodynia) phenomena, common in neuropathic pain, are not captured. To evaluate the overall effectiveness of a treatment, improvement of all sensory symptoms should be measured. Since the pattern of sensory abnorm...

journal_title：Current medical research and opinion

authors： Höper J,Helfert S,Heskamp ML,Maihöfner CG,Baron R

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Non-adherence to pain medication is common in chronic pain patients and may result in unfavorable treatment outcomes. Interventions to improve adherence behavior often fail to significantly change medication use. In this report, we describe the application of a theoretical psychological model of behavior chan...

journal_title：Current medical research and opinion

authors： Timmerman L,Stronks DL,Huygen FJPM

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Aliskiren is the first in a new class of orally effective direct renin inhibitors approved for the treatment of hypertension. This multiple-dose study investigated the potential for pharmacokinetic interactions between aliskiren and three drugs, each predominantly eliminated by a different clearance/metabolic...

journal_title：Current medical research and opinion

authors： Ayalasomayajula S,Tchaloyan S,Yeh CM,Bizot MN,Dieterich HA,Howard D,Dole WP

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...

journal_title：Current medical research and opinion

authors： Sathyan G,Phipps B,Gupta SK

更新日期：2009-02-01 00:00:00

abstract：:Objective: Health utility estimates for children and adolescents are critical for cost-utility analyses informing health technology assessment (HTA) authorities' decisions governing access to pediatric treatments. However, in a recent review, only 29% of published pediatric cost-utility models used a utility measure v...

journal_title：Current medical research and opinion

authors： Bégo-Le Bagousse G,Jia X,Wolowacz S,Eckert L,Tavi J,Hudson R

更新日期：2020-07-01 00:00:00

abstract：:Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most com...

journal_title：Current medical research and opinion

authors： Manolis TA,Manolis AA,Apostolopoulos EJ,Papatheou D,Melita H,Manolis AS

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, has been shown to increase platelet counts in adults with chronic immune thrombocytopenia and chronic hepatitis C. This multicenter phase 2 study assessed the efficacy and safety of eltrombopag in patients receiving first-line carboplatin/pacl...

journal_title：Current medical research and opinion

authors： Kellum A,Jagiello-Gruszfeld A,Bondarenko IN,Patwardhan R,Messam C,Mostafa Kamel Y

更新日期：2010-10-01 00:00:00

abstract：:Women who are diagnosed with early breast cancer remain at considerable risk of recurrence over the next several decades, even if their tumors were small and lymph nodes were negative, and despite receiving standard adjuvant therapy. A majority of breast cancers are hormone (estrogen) receptor-positive and amenable to...

journal_title：Current medical research and opinion

authors： Chowdhury S,Ellis P

更新日期：2005-12-01 00:00:00

abstract：:A randomized study was performed on 24 patients with ankylosing spondylitis to compare the efficacy and tolerability of 20 mg tenoxicam daily with 50 mg diclofenac twice daily. There were 6 withdrawals from the group taking tenoxicam and 4 from the diclofenac group. Depression in 1 patient taking tenoxicam was the onl...

journal_title：Current medical research and opinion

authors： Schwarzer AC,Cohen M,Arnold MH,Kelly D,McNaught P,Brooks PM

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Niacin is currently the most effective approved agent for raising high-density lipoprotein cholesterol. However, niacin-induced cutaneous flushing (redness, warmth, tingling and/or itching) significantly limits patient acceptance. To further characterize flushing, a patient-reported Flushing Symptom Question...

journal_title：Current medical research and opinion

authors： Norquist JM,Watson DJ,Yu Q,Paolini JF,McQuarrie K,Santanello NC

更新日期：2007-07-01 00:00:00

abstract：:For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropr...

journal_title：Current medical research and opinion

authors： Jatoi I

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Although a reduced aflibercept (2.0 mg) injection frequency relative to the approved dosing posology is included in national treatment guidelines for wet age-related macular degeneration (AMD), there is limited evidence of its comparative efficacy. The objective was to compare the efficacy and safety of reduc...

journal_title：Current medical research and opinion

authors： Szabo SM,Hedegaard M,Chan K,Thorlund K,Christensen R,Vorum H,Jansen JP

更新日期：2015-11-01 00:00:00