[Beta-adrenergic blockers in congestive heart failure: pro et contra?].

Abstract:

:In every patient with congestive heart failure there is a secondary neurohumoral response including increase in serum noradrenaline, renin, angiotensin, aldosteron and antidiuretic hormone or arginine-vasopressin values. Plasma and urine noradrenaline levels are increased proportionally to the severity of ventricular dysfunction, but its reserve is often reduced in the myocardium as well as the density of beta receptors and sensitivity to catecholamines and inotropic responses to the stimulation of adrenergic nerves. Down-regulation of beta-adrenoceptors in the myocardium, verified by the technique of radioligands, with the reduced number of beta-adrenoceptors, is accompanied by the appearance of refractoriness and desensitization to endogenous and exogenous catecholamines. Chronic beta-blockade may improve haemodynamic and clinical function in patients with dilated cardiomyopathy or congestive heart failure, because beta-blockers have potentially beneficial actions: protection of the myocardium from damage by chronic excessive catecholamine stimulation, restoration toward normal of the down-regulated membrane beta-receptor density often seen in heart failure, reduction in the risk of potentially lethal ventricular arrhythmias and beneficial effects on substrate utilization. Our results of investigation in 20 patients with congestive heart failure treated with beta-blockers short and long-term (average 22 months) gave substantial increases in ejection cardiac index and improved functional class and also improved working capacity.

journal_name

Srp Arh Celok Lek

authors

Trifunović SL,Pavlović K

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

44-50

eissn

0370-8179

issn

2406-0895

journal_volume

120 Suppl 4

pub_type

杂志文章
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    authors: Vučinić P,Vukić-Ćulafić B,Ivić S

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  • [Rubinstein-Taybi syndrome].

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    authors: Grković S,Jesić M,Jesić M,Maglajlić S

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    pub_type: 杂志文章

    doi:

    authors: Savić G

    更新日期:2016-03-01 00:00:00

  • [Moderate ischemic mitral regurgitation: to operate or to ignore?].

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  • [How the epidemics of typhus and relapsing fever were stopped in Serbia in 1915 year].

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Litvinjenko S

    更新日期:1995-11-01 00:00:00

  • Coagulation disturbances in paediatric patients with hepatic veno-occlusive disease after stem cells transplantation.

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh10s1033j

    authors: Jevtić D,Vujić D,Zecević Z,Veljković D,Gazikalović S,Elezović I

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  • [Organization of the program for prevention and control of nosocomial infections in France].

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    pub_type: 杂志文章

    doi:

    authors: Marković-Denić Lj,Quenon JL,Broden M

    更新日期:1999-11-01 00:00:00

  • [Symptomatic calcified splenic artery aneurysm: case report].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1012760c

    authors: Čolović R,Čolović N,Grubor N,Kaitović M

    更新日期:2010-11-01 00:00:00

  • Compliance with hypertension guidelines in general practice in Slovenia.

    abstract:INTRODUCTION:Compliance with hypertension guidelines in clinical practice is generally poor, but there was no data about compliance with any guidelines in general practice in Slovenia. OBJECTIVE:Our aim was to find out whether general practitioners in Slovenia managed their hypertensive patients according to the natio...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0704191p

    authors: Petek-Ster M,Kersnik J,Svab I

    更新日期:2007-03-01 00:00:00

  • [Steroid receptors and NK cell activity in patients with breast cancer].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Konjević G,Branković-Magić M,Nikolić-Vukosavljević D,Spuzić I

    更新日期:1994-05-01 00:00:00

  • [Maria Müller (1883-?) M.D., ophthalmologist: biographical notes].

    abstract::Maria Müller was one of the first female ophthalmologists in Serbia. Having researched the documents from several archives in Serbia-Belgrade, Novi Sad and Sremska Mitrovica, we were able to follow her life and work. Maria Müller was born in Budapest in 1883. From 1909 to 1919 she worked at the Budapest Hungarian Roya...

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    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Litričin V

    更新日期:2012-01-01 00:00:00

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Stosić M,Cenić G,Stosić C

    更新日期:1994-09-01 00:00:00

  • [Breech presentation at term: caesarean section or vaginal delivery?].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1104155d

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  • [Factors mediating the depression in the adult obese outpatients].

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    pub_type: 杂志文章

    doi:10.2298/sarh0702061g

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    pub_type: 杂志文章,评审

    doi:10.2298/sarh1302104s

    authors:

    更新日期:2013-01-01 00:00:00

  • [Mortality from heart attack in Belgrade population during the period 1990-2004].

    abstract:INTRODUCTION:In most countries, cardiovascular diseases are the leading disorders, with ischemic heart diseases being the leading cause of death. According to WHO data, every year about 17 million people die of cardiovascular diseases, which is 30% of all deaths. Ischemic heart diseases contribute from one-third to one...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0812598r

    authors: Ratkov I,Sipetić S,Vlajinac H,Sekeres B

    更新日期:2008-11-01 00:00:00

  • [Natural history of supratentorial low-grade astrocytoma: case report].

    abstract::Low-grade astrocytomas comprise a group of primary brain neoplasms with relatively low anaplastic potential, although through time they tend to behave more aggressively. They have a very heterogeneous natural course and clinical behavior. This report presents a natural history of a patient with low grade astrocytoma. ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0612537r

    authors: Radulović D

    更新日期:2006-11-01 00:00:00

  • [Lupus nephritis: retrospective analysis of the course of the disease].

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    pub_type: 杂志文章

    doi:

    authors: Djukanović L,Pavlović S,Blagojević R,Dimitrijević J,Stojsic T,Ratković M,Kazić K,Lezaić V,Naumović R

    更新日期:2002-08-01 00:00:00

  • [External fixation war injuries of the proximal humerus].

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    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

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    authors: Mirić D,Senohradski K,Starcević B,Djordjević Z

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  • [The role of endothelial cells in allergic inflammation reactions].

    abstract::Inflammatory response in tissue results from a complex network of interactions between inflammatory cells (mast cells, eosinophils, basophils, macrophages) and resident cells belonging to the lung structure (like endothelial cells, fibroblasts, epithelial cells). Among structural cells, endothelial cells play a critic...

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    pub_type: 杂志文章,评审

    doi:

    authors: Stefanović Lj,Bogić M,Balaban J,Mitrović O,Stosović R,Andrejević S

    更新日期:1998-03-01 00:00:00

  • [Chlamydia trachomatis infection in newborn infants].

    abstract::The aim of our study was to examine the frequency of Chlamydia trachomatis infection in newborns by detecting specific antibodies, and to examine the Apgar score and the birth weight of Chlamydia trachomatis-antibody positive children. Fifty-two newborn infants were tested. High serum IgG chlamydial specific antibody ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Djukić S,Nedeljković M,Pervulov M,Bojić V,Ljubić A,Radunović N,Lazarević B

    更新日期:1995-09-01 00:00:00

  • [Effect of enalapril on progression of chronic renal insufficiency caused by diabetes and other etiologies: a 2-year study].

    abstract::Chronic renal failure (CRF) is almost always associated with high arterial blood pressure. Adequate control of hypertension slows down the progression of the disease, Inhibitors of angiotenzin-converting enzyme (ACE inhibitors) have proved to be very efficacious in decreasing high blood pressure. The aim of this study...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0204087t

    authors: Trbojević J,Stojimirović B

    更新日期:2002-03-01 00:00:00

  • Adverse Effects of Pharmacological Therapy of Benign Prostatic Hyperplasia on Sexual Function in Men.

    abstract:INTRODUCTION:The development of effective medications makes pharmacological therapy of BPH the dominant mode of treatment today. It improves urinary symptoms and prevents disease progression while producing side effects on male sexual function. OBJECTIVE:The aim of the study is to present the effects of BPH pharmacolo...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1506284s

    authors: Stojanović N,Ignjatović I,Djenić N,Bogdanović D

    更新日期:2015-05-01 00:00:00

  • [Early risk predictors of sudden cardiac death after myocardial infarction: results of follow up of 881 patients].

    abstract:INTRODUCTION:It has been shown that depolarization disorders, autonomic dysfunction, and systolic dysfunction of the left ventricle are associated with sudden cardiac death after myocardial infarction. OBJECTIVE:The objective of study was to examine the prognostic value of the most important predictors in the first we...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0612482m

    authors: Milovanović B,Krotin M,Vuković D,Bisenić V,Mirjanić T,Nikolić S

    更新日期:2006-11-01 00:00:00

  • [Intramural haematoma and penetrating aortic ulcer--outcome and treatment modalities: report of four cases].

    abstract:INTRODUCTION:Intramural haematoma (IMH) and penetrating aortic ulcers (PAU) are the frequent cause of acute aortic syndrome that is disclosed with a rising frequency due to the development of new diagnostic methods. Different symptoms contribute to clinical misdiagnosis, while changeable locations and unpersuasive diam...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1106380k

    authors: Končar I,Davidović L,Čolić M,Dragaš M,Ilić N,Menković N,Vučković M,Kalimanovska-Oštrić D,Cvetković S,Kostić D

    更新日期:2011-05-01 00:00:00

  • [Development of pharmacy in the Leskovac region for the period from liberation from the Turks until World War II].

    abstract::From the historical point of view, there are three time periods when the process of modernization of Serbian society took place. First period includes the interval from the beginning of the 19th century until the end of World War I, when the Serbian country was reestablished as Serbian Knezevina (princedom) and in 188...

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Milić P,Milić S

    更新日期:2013-11-01 00:00:00

  • [Effect of obesity on metabolic processes in bone tissue].

    abstract::The aim of the present study was to evaluate the state of bone mass in obese individuals. Osteocalcin (OC) and parathormone (PTH) were measured (by RIA) in the sera of 137 obese, 32 premenopausal women, 65 postmenopausal women and 40 males, as well as in 28 controls, non-obese individuals. Values of OC and PTH were si...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Pudar G,Branković S,Perić Lj,Beljić T

    更新日期:1994-03-01 00:00:00

  • Evaluation of Surfactant Replacement Therapy Effects--A New Potential Role of Lung Ultrasound.

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  • Implementation of multiple intelligences theory in the English language course syllabus at the University of Nis Medical School.

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    pub_type: 杂志文章

    doi:

    authors: Bakić-Mirić N

    更新日期:2010-01-01 00:00:00

  • [Newborn hearing screening].

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    更新日期:2007-05-01 00:00:00