[Biologic effects and possible therapeutic use of the granulocyte-macrophage colony-stimulating factor. Modern treatment of leukopenia].

Abstract:

:This review is a brief overview of recent advances in biology as well as in potential clinical application of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF). Biologically active rhGM-CSF is a recombinant human protein expressed in Escherichia coli. GM-CSF is produced by nontransformed (T-lymphocytes, trophoblasts, keratinocytes, osteoblasts, tracheal epithelial cells, renal mesangial cells, endothelial cells, macrophages, fibroblasts, smooth muscle cells) and transformed (murine plasmocytoma, bladder carcinoma HIBY cell line, anaplastic carcinoma of the gall bladder, Yoshida sarcoma cell line, HC3T3-osteoblast cell line) cells. RhGM-CSF increases the number of circulating neutrophils, monocytes and eosinophils and increases chemotactic, microcidal killing and cytotoxic activity of monocytes and granulocytes. The present clinically relevant uses of rhGM-CSF two general areas: restoration of haematopoietic dysfunction by raising cell counts from suppressed to normal levels, and augmentation of host defence against infection. Thus, rhGM-CSF reduces risk of infections. In addition, rhGM-CSF may increase tumour cell destruction in some malignant diseases. RhGM-CSF produces dose-dependent toxicity consisting of myalgic fever, fluid retention and serosal effusions.

journal_name

Srp Arh Celok Lek

authors

Jovanović-Mićić D,Beleslin DB,Bosnjak S

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

152-4

issue

8-12

eissn

0370-8179

issn

2406-0895

journal_volume

121

pub_type

杂志文章,评审
  • [Drug facilitated sexual assault].

    abstract::In line with the fact that there is little information regarding drug facilitated sexual assault in national medical literature, the authors aimed to prepare a review of the phenomenon based on available international references. Therefore we offered a definition of the concept of sexual assault, and rape in particula...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Alempijević D,Savić S,Stojanović J,Spasić A

    更新日期:2007-03-01 00:00:00

  • Development and evaluation of the nurse quality of communication with patient questionnaire.

    abstract:INTRODUCTION:Nurse/patient relationship as a complex interrelation or as an interaction of the factor patient and factor nurse has been a subject of a number of studies during the past ten years. Nurse/patient communication is a special entity, usually observed within a framework of the wider nurse/patient relationship...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1002079v

    authors: Vuković M,Gvozdenović BS,Stamatović-Gajić B,Ilić M,Gajić T

    更新日期:2010-01-01 00:00:00

  • [Ancient Greek in modern language of medicine].

    abstract::In order to standardize language of medicine, it is essential to have a good command of ancient Greek and Latin. We cannot deny a huge impact of ancient Greek medicine on medical terminology. Compounds of Greek origin related to terms for organs, illnesses, inflammations, surgical procedures etc. have been listed as e...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0710606m

    authors: Marković V

    更新日期:2007-09-01 00:00:00

  • Prevalence of Enterococcus faecalis and Porphyromonas gingivalis in infected root canals and their susceptibility to endodontic treatment procedures: a molecular study.

    abstract:INTRODUCTION:Because apical periodontitis is recognizably an infectious disease, elimination or reduction of intracanal bacteria is of utmost importance for optimum treatment outcome. OBJECTIVE:The prevalence of Enterococcus faecalis and Porphyromonas gingivalis in infected root canals was studied Also, the effect of ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1410535s

    authors: Stojanović N,Krunić J,Popović B,Stojičić S,Zivković S

    更新日期:2014-09-01 00:00:00

  • Urgent hybrid approach in treatment of the acute myocardial infarction complicated by the ventricular septal rupture.

    abstract:INTRODUCTION:Ventricular septal rupture (VSR) in the acute myocardial infarction (AMI) is a rare but very serious complication, still associated with high mortality, despite significant improvements in pharmacological and surgical treatment. Therefore, hybrid approaches are introduced as new therapeutical options. CAS...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1404226r

    authors: Radosavljević-Radovanović M,Radovanović N,Arandjelović A,Mitrović P,Usćumlić A,Stanković G

    更新日期:2014-03-01 00:00:00

  • [Management of idiopathic nephrotic syndrome in childhood].

    abstract::The management of idiopathic nephrotic syndrome (INS) in children includes immunosuppressive and symptomatic treatment. The response to corticosteroid therapy is the best prognostic marker of the disease. The majority of children with INS (about 85%) are steroid-sensitive as they normalize proteinuria within 4 weeks o...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh0410352p

    authors: Peco-Antić A

    更新日期:2004-09-01 00:00:00

  • [The change concentrations in the serum of immunoglobulins and alpha-1 atitrypsin in children with obstructive pulmonary diseases].

    abstract::Total concentrations of IgA, IgM, IgG, IgE and alpha-antitypsin were determined in the sera of 50 children of different age with bronchial asthma and obstructive bronchitis and 20 healthy children as control group. By using radial immunodifusion method the total IgA, IgM, IgG and alpha-antitrypsin were determined. Sig...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Miljković D,Dzelebcjić J,Kostić N

    更新日期:1995-05-01 00:00:00

  • Ameloblastic fibroma: a rare case report with 7-year follow-up.

    abstract:INTRODUCTION:Ameloblastic fibroma (AF) is a rare benign odontogenic tumor that usually occurs in the fi two decades of life. It affects adolescents and young adults and is found in the mandible and with a high frequency in the posterior region of this segment. There are rare case reports with a long-term follow-up. CA...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1504190a

    authors: Melo Lde A,Barros AC,Sardinha Sde C,Cerqueira A,dos Santos JN

    更新日期:2015-03-01 00:00:00

  • Changing the structure of the hospitalized patients at the Psychiatric Clinic Vrapce.

    abstract:INTRODUCTION:Psychiatric treatment in developed countries has significantly changed in the last few decades, with a significant shortening of the duration of hospitalization. Numerous West European countries are undertaking health system reforms to improve treatment efficiency. OBJECTIVE:The aim of the study was to pr...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Bilić P,Ivanis A,Vidović D,Jukić V

    更新日期:2011-12-01 00:00:00

  • Adverse Effects of Pharmacological Therapy of Benign Prostatic Hyperplasia on Sexual Function in Men.

    abstract:INTRODUCTION:The development of effective medications makes pharmacological therapy of BPH the dominant mode of treatment today. It improves urinary symptoms and prevents disease progression while producing side effects on male sexual function. OBJECTIVE:The aim of the study is to present the effects of BPH pharmacolo...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1506284s

    authors: Stojanović N,Ignjatović I,Djenić N,Bogdanović D

    更新日期:2015-05-01 00:00:00

  • [Treatment of esotropia with a high AC/A ratio].

    abstract::We have treated 55 children with accommodative esotropia and high AC/A ratio with progressive addition lenses, measured by heterophoria method. All of them wear full hyperopic refraction for distance and addition of +1.00 to 3.5 spheres for near vision. The minimal add that allowed the maximal reduction in the near de...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Risović D

    更新日期:2003-01-01 00:00:00

  • [Tension-free procedures in the surgical treatment of groin hernias].

    abstract::Hernia repair is one of the most common surgical procedures performed in the United States, with 700,000 operations performed each year. Improvements in surgical technique, together with the development of new prosthetic materials and a better understanding of how to use them, have significantly improved outcomes for ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh0302082m

    authors: Milić DJ,Pejić MA

    更新日期:2003-01-01 00:00:00

  • [Post-traumatic systemic fat embolism syndrome. Retrospective autopsy study].

    abstract:INTRODUCTION:The obstruction of blood vessels or heart chambers with fat globules, reached by circulation, is fat embolism [1, 2]. Clinical manifestation of the presence of fat emboli in vital organs is Fat Embolism Syndrome (FES). This syndrome is characterized by neurologic, respiratory and cutaneous signs and differ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Nikolić S,Micić J,Savić S,Uzelac-Belovski Z

    更新日期:2000-01-01 00:00:00

  • [Solid and cystic-papillary tumor of the pancreas].

    abstract::Solid and cystic-papillary tumour of the pancreas is a rare neoplasm. About 420 cases seem to have been reported as yet. It appears almost exclusively in young women, although it may appear in males in all ages. This is a tumour of benign or low malignant potential with vary rare invasion of surrounding tissues and or...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Colović R,Micev M,Zogović S,Colović N,Stojković M,Grubor N

    更新日期:2000-11-01 00:00:00

  • [Clinical manifestations of familial hypercholesterolemia].

    abstract::Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited disorder clinically characterized by high serum cholesterol (low-density lipoprotein--LDL-fraction) concentrations, xanthomas and premature atherosclerosis. Homozygous individuals suffer from vascular disease in childhood or young adolescence since...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Ivanović-Krstić B,Kalimanovska-Ostrić D,Cvetković-Matić D,Simić D,Djukić P,Nikcević Dj

    更新日期:2000-03-01 00:00:00

  • [Treatment of missed Monteggia lesion in children--case report].

    abstract:INTRODUCTION:A Monteggia lesion is a dislocation of the radial head associated with a fracture with the proximal third of the ulna. It is rare in children and the dislocation of the radial head is often missed at the time of injury. There are a lot of described treatment methods: open reduction of the radial head and r...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1102099v

    authors: Vukasinović Z,Jovanović V,Mitović D,Slavković N

    更新日期:2011-01-01 00:00:00

  • [Serum antithyroid antibodies in patients with pernicious anemia].

    abstract::We investigated the incidence of thyroid auto-antibodies and their relationship to antigastric antibodies in 20 euthyroid patients with pernicious anaemia. To evaluate possible thyroid dysfunction we also measured total level of thyroid hormones (TT3 and TT4) and TSH in our patients. Histologic evidence of autoimmune ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Kostić N,Jelić S,Han R,Ristić S,Bozanić M

    更新日期:1990-07-01 00:00:00

  • [Organization of the program for prevention and control of nosocomial infections in France].

    abstract::Nosocomial infections (NI) are infections acquired in hospitals. The aim of this paper is to describe the organization of NI control program in France. The organization of this program started in 1988 by the formation of the Infection Control Committees in hospitals. Their role has been to organize the surveillance of...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Marković-Denić Lj,Quenon JL,Broden M

    更新日期:1999-11-01 00:00:00

  • [Ewing sarcoma--analysis of epidemiological parameters and their relation to clinical characteristics].

    abstract::The purpose of this investigation was to evaluate epidemiologic features of Ewing sarcoma in children treated in the Institute for Orthopedic Surgery "Banjica: as well as to establish relation of these features to clinical findings. Study involved 78 patients treated over 20-year period (1980-2000). Analysis included ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0608310s

    authors: Stevanović V,Vukasinović Z,Spasovski D

    更新日期:2006-07-01 00:00:00

  • [The treatment of subtrochanteric fractures].

    abstract::Subtrochanteric fractures of the femur have a special place because of a significant number of complications following treatment. Powerful loading forces asymmetrically acting to this bone segment, as well as poor vascularization interfere with bone union. There are basically two current approaches in the fixation of ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:10.2298/sarh1108540v

    authors: Vučetić CS,Dulić BV,Vukašinović ZS,Tulić GD,Kalezić NK

    更新日期:2011-07-01 00:00:00

  • [Ewing's sarcoma in children: prognosis in relation to the method of treatment].

    abstract::Ewing's tumor of bone is the second primary malignant bone tumor. Localized lesion is found in nearly 80% of cases and metastatic lesions are present in 20% at the time of diagnosis. Treatment protocols were analyzed, prognostic parameters were evaluated, and overall survival as well as survival until relapse of disea...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh0610420s

    authors: Stevanović V,Vukasinović Z,Spasovski D

    更新日期:2006-09-01 00:00:00

  • Heterotopic pregnancy after in vitro fertilization and embryo transfer: a case report.

    abstract:INTRODUCTION:Heterotopic pregnancy is a life-threatening complication of pregnancy defined as coexistent intrauterine and ectopic gestation. Its diagnosis is frequently overlooked and delayed. CASE OUTLINE:A 28-year-old woman experienced acute abdominal pain in pregnancy achieved by in vitro fertilization. Since all p...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Sparić R,Buzadzić S,Argirović R,Bratić D,Plećas D

    更新日期:2012-07-01 00:00:00

  • A Case of Autoimmune Cholangitis Misdiagnosed for Cholangiocarcinoma: How to Avoid Unnecessary Surgical Intervention?

    abstract:INTRODUCTION:Autoimmune cholangitis or immunoglobulin G4-associated cholangitis (IAC) has been recently regarded as a new clinical and histopathological entity and is a part of a complex autoimmune disorder--IgG4-related systemic disease (ISD). ISD is an autoimmune disease with multi-organic involvement, characterized ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1506337i

    authors: Ignjatović II,Matić SV,Dugalić VD,Knežević DM,Micev MT,Marko D Bogdanović,Knežević SM

    更新日期:2015-05-01 00:00:00

  • Ability to solve riddles in patients with speech and language impairments after stroke.

    abstract:INTRODUCTION:Successful riddle solving requires recognition of the meaning of words, attention, concentration, memory, connectivity and analysis of riddle content, and sufficiently developed associative thinking. OBJECTIVE:The aim of the study was to determine the ability to solve riddles in stroke patients who do or ...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Savić G

    更新日期:2016-03-01 00:00:00

  • [What language is your doctor speaking? Facing the problems of translating medical documents into English].

    abstract::What is translation--a craft, an art, a profession or a job? Although one of the oldest human activities, translation has not still been fully defined, and it is still young in terms of an academic discipline. The paper defines the difference between translation and interpreting and then attempts to find the answer to...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Mićović D

    更新日期:2013-07-01 00:00:00

  • [The Jones diagnostic criteria for rheumatic fever].

    abstract::The apparent fall of rheumatic fever incidence in developed countries and in Yugoslavia is one of the reasons of negligence of the diagnosis of this disease. This fall was associated with mild forms of rheumatic fever (arthritis and mild forms of carditis are the main manifestations) where the beginning resembled othe...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Vukotić D,Radak-Perović M

    更新日期:1989-01-01 00:00:00

  • [Subclinical thyroid disease--should we treat, should we screen for it?].

    abstract::Subclinical thyroid disease is defined by an abnormally high (subclinical hypothyroidism) or low (subclinical hyperthyroidism) serum thyrotropin (TSH) with peripheral thyroid hormone concentrations within the laboratory reference ranges. Such abnormalities in thyroid function tests are very common in the population an...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章,评审

    doi:

    authors: Trbojević B

    更新日期:2003-11-01 00:00:00

  • [Buspirone in the treatment of cerebellar ataxia].

    abstract::Ataxia is defined as a disturbance which, quite independent of any motor weakness, alters direction and extent of voluntary movement and impairs the sustained voluntary of reflex muscle contraction necessary for maintaining postiue and equilibrium [1]. Since pathophysiological basis of cerebeller ataxia is still not c...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 临床试验,杂志文章

    doi:

    authors: Svetel M,Vojvodić N,Filipović SR,Dragasević N,Sternić N,Kostić VS

    更新日期:1999-09-01 00:00:00

  • [Cytology in the diagnosis of diseases of the nose and maxilary sinuses].

    abstract::The aim of this work is to evaluate cytologic examination of secretions of nose and maxillary sinuses in patients with naso-sinusal disorders. The material for cytologic examination is taken from 128 nasal cavities of 101 patients with inflammation or tumour diseases of nose and maxillary sinuses, and from 114 maxilla...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:

    authors: Belić B,Andrić V,Tadić L,Vasković Z,Stojanović S,Krsmanović J

    更新日期:2002-05-01 00:00:00

  • Small bowel adenocarcinoma mimicking a large adrenal tumor.

    abstract:INTRODUCTION:Adenocarcinoma of the small bowel is a rare gastrointestinal neoplasm usually affecting the distal duodenum and proximal jejunum. Because of their rarity and poorly defined abdominal symptoms, a correct diagnosis is often delayed. CASE OUTLINE:We present a 43-year-old woman admitted at the Clinic for Endo...

    journal_title:Srpski arhiv za celokupno lekarstvo

    pub_type: 杂志文章

    doi:10.2298/sarh1304232i

    authors: Ivović M,Zivaljević V,Vujović S,Marina L,Gajić MT,Dundjerović D,Barać M,Micić D

    更新日期:2013-03-01 00:00:00