Abstract：
INTRODUCTION:Non-small cell lung cancer (NSCLC) accounts for about 70-80% of all lung cancers. In comparison with small cell lung cancer, NSCLC has relatively low therapy response. Discovery of neuroendocrine markers within the NSCLC group (10-30%) has initiated the issue of their importance in the therapy and prognosis. OBJECTIVE:The aim of this study was to determine the influence of neuroendocrine differentiation on treatment response and survival in patients with advanced NSCLC. METHODS:A clinical trial included 236 patients (73.7% males), with diagnosis of NSCLC, determined by histological verification. These patients were treated by combined chemo- and X-ray therapy at stage III (without pleural effusion) or chemotherapy only at stage III (with pleural effusion) and stage IV of NSCLC. When the progression had been noted at the stage III (without pleural effusion), the treatment was continued with X-ray therapy. Neuron-specific enolase (NSE), chromogranin A (ChrA) as well as synapthophysin (SYN) expression in tissue examples was determined by immunohistochemical analysis with monoclonal mouse anti human bodies (DAKO Comp, Denmark). The treatment was conducted during 4 to 6 chemotherapeutic cycles. The efficacy was assessed after the therapy regimen; median survival time was assessed after the randomization. RESULTS:NSE, ChrA and SYN expression were noted in 56 (23.7%), 33 (13.9%) and 39 (16.5%) patients, respectively. Better therapeutic response was significantly higher in patients with expression of NSE, ChrA and SYN (p < 0.05). There was significant correlation between therapy response and the percentage of positive tumour cells with neuroendocrine differentiation (p < 0.05). The one-year and two-year follow-up survival period in patients with neuroendocrine expression was 64% (without expression 28%; p < 0.001) and 30% (p = 0.000). CONCLUSION:Tissue expression of neuroendocrine markers influences greatly a therapeutic response in patients with advanced stage of NSCLC. Better therapeutic response was recorded in patients with possitive expression of neuroendocrine markers and higher percentage of positive tumour cells. Median survival time is higher in patients in Ill or IV stage of NSCLC, when neuroendocrine markers are expressed.
journal_name
Srp Arh Celok Lekjournal_title
Srpski arhiv za celokupno lekarstvoauthors
Petrović M,Ilić N,Baskić Ddoi
10.2298/sarh1002037psubject
Has Abstractpub_date
2010-01-01 00:00:00pages
37-42issue
1-2eissn
0370-8179issn
2406-0895journal_volume
138pub_type
杂志文章abstract：INTRODUCTION:The paper describes a very rare, isolated exocranial complication of the purulent frontal sinus inflammation. Frontal bone osteomyelitis occurs either in the course of an acute episode or during the exacerbation of a chronic disease. By distribution, it can be diffuse or circumscript. It is more common in ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0804154s
更新日期：2008-03-01 00:00:00
abstract：:The objective of the study was to test the possibility of using the fixed value (12-13) of the Rating of Perceived scale (RPE scale), as a valid method for determination of ventilatory threshold (VT). The sample of the subjects included 32 physically active males (age: 22.3; TV: 180.5; TM: 75.5 kg; VO2max: 57.1 mL/kg/...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0412409s
更新日期：2004-11-01 00:00:00
abstract：:Detrusor tunnelling is an extravesical surgical procedure of ureteral reimplantation. It is surely the least traumatic method of surgical correction of vesico-ureteral reflux because antireflux mechanism is achieved with minimal detrusor muscle dissection. This procedure simplifies implantation of dilated ureters, dou...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:Cesarean delivery is the most common obstetric surgery today. Improvement of operative techniques, anaesthesia, care and transfusion has contributed to the safety of the procedure and expansion of indications. The operative technique usually consists of opening the abdominal wall by inferior transverse inc...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,随机对照试验
doi：10.2298/sarh08s2109v
更新日期：2008-05-01 00:00:00
abstract：:From the historical point of view, there are three time periods when the process of modernization of Serbian society took place. First period includes the interval from the beginning of the 19th century until the end of World War I, when the Serbian country was reestablished as Serbian Knezevina (princedom) and in 188...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 历史文章,杂志文章
doi：
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Heterotopic pregnancy is a life-threatening complication of pregnancy defined as coexistent intrauterine and ectopic gestation. Its diagnosis is frequently overlooked and delayed. CASE OUTLINE:A 28-year-old woman experienced acute abdominal pain in pregnancy achieved by in vitro fertilization. Since all p...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:A sudden onset of the syndrome Guillain-Barré in 48-year-old woman presenting as an acute motor neuropathy was associated with antibodies against ganglioside GM1 detected by ELISA. The neurological examination revealed flaccid quadriplegia without affection of the sensory system, and the additional investigation showe...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：INTRODUCTION:In the last few years, an increasing number of patients suffering from terminal renal disease of various leading causes was treated with renal replacement therapy. Peritonaeal dialysis involves an exchange of water and solutes between blood in the peritonaeal capillaries and dialysate in the peritonaeal ca...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0512498j
更新日期：2005-11-01 00:00:00
abstract：:In diabetic patients, without coronary heart disease and hypertension, left ventricular filing dysfunction exist, that is registered by echocardiography. It is manifested as greater peak flow velocity during atrial systole and as shorter time from the aortic second heart sound to the peak of the early diastolic flow v...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Bladder cancer is a common form of neoplasia which most often presents histologically as urothelial (transitional cell) carcinoma. In this article we review recent publications dealing with the less common variants of urothelial carcinoma such as tumours that show unusual forms of differentiation or the well know squa...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:Blood counts, bone marrow cytology and iron status in 13 patients with severe renal anemia assessed prior to and after recombinant human erythropoietin treatment. The mean increase of PCV after 8 weeks of treatment was 50%. Simultaneously, we observed a fourfold increase of the reticulocyte count. This increment corre...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:Dr. Lazar K. Lazarević (1851-1890, Julian calendar/1891, Gregorian calendar) was an exceptional Serbian physician, scientist, writer and translator. During his short life and his close to 11-year-long professional career (1879-1890), Dr. Lazarević authored 78 scientific papers and presentations in various branches of ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 历史文章,杂志文章
doi：10.2298/sarh1602111d
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:In clinical setting, the symptoms of the impaired motor behavior in patients with different neurological diseases are identified by classical tests incorporated in clinical neurological examination. New computerized methods for objective motor assessment have been recently suggested in the literature. We dev...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Orofacial pain occurs in various disorders of the orofacial region. OBJECTIVE:The aim of this study was to examine applicability of the visual-analogue scale (VAS) in patients with orofacial pain (model of acute and chronic pain). METHODS:The study involved 60 patients, aged 18-70 years. The first group ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2013-07-01 00:00:00
abstract：:The frequency and the degree of bronchial hyperreactivity was investigated in 92 patients suffering from chronic obstructive bronchitis. Bronchial reactivity was examgned by the inhalator acetylcholine test, with the use of a 5 mg dose of acetylcholine, diluted in 1 ml of sodium-chloride solution. The pulmonary functi...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Hernia repair is one of the most common surgical procedures performed in the United States, with 700,000 operations performed each year. Improvements in surgical technique, together with the development of new prosthetic materials and a better understanding of how to use them, have significantly improved outcomes for ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：10.2298/sarh0302082m
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:L-asparaginase (L-ASP) is one of the most effective medications for the treatment of acute lymphoblastic leukaemia (ALL) in children, and allergic reactions to the therapy are considered the most significant side effects. OBJECTIVE:The aim of this study was to determine the prevalence and type of allergic...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1112749k
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole), according to protocol recommended by Center for Disease Control (CDC, formerly called: Communicable Disease Center) [19]. The resistance of Trichomonas vaginal...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0304156v
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:The function of root canal fillings is to seal the root canal system. The important physical property necessary for sealers to achieve this is low solubility. However, any therapeutic effect of calcium hydroxide-based sealers is dependent on the calcium hydroxide being in ionized form, which implies that t...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:The existing data bases - on the number and distribution of the injured are unfortunately unreliable and very poor. There is also a shortage of information needed in assessing human and financial aspect of the trauma as well as physical, social, economic and psychological circumstances under wich injuries have heppene...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：INTRODUCTION:Considering operative treatment of various pathological conditions and traumatic injuries of extremities latissimus dorsi flap presents the most frequently used flap in reconstructive surgery. OBJECTIVE:The aim of this paper was to analyze anatomical characteristics of the vascular pedicle of the latissim...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1008449i
更新日期：2010-07-01 00:00:00
abstract：:Nosocomial infections (NI) are infections acquired in hospitals. The aim of this paper is to describe the organization of NI control program in France. The organization of this program started in 1988 by the formation of the Infection Control Committees in hospitals. Their role has been to organize the surveillance of...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：INTRODUCTION:Nosocomial infections (NIs) are a serious health problem in hospitals worldwide and are followed by a series of consequences, medical, judicial, ethical and economic. OBJECTIVE:The main aim of this study was to assess the magnitude of NIs at the Clinical Centre in Kragujevac. METHODS:A prevalence study o...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1006337i
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:Although the third most common aneurysm within the abdomen, after aneurysms of the aorta and iliac arteries, splenic artery aneurysms are rare, but not exceptionally. Owing to new imaging techniques, they have been discovered with increasing frequency. CASE OUTLINE:Authors present a 47-year-old woman, mul...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1012760c
更新日期：2010-11-01 00:00:00
abstract：:The purpose of this study was to analyse, by immunomorphometry, megakaryocytopoiesis in patients with myelodysplatsic syndrome. The results revealed that, in spite of marked megakaryocyte hyperplasia, patients with myelodysplastic syndrome suffer from severe peripheral thrombocytopenia. Megakaryocytes in myelodisplast...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Secretory otitis media is defined as a fluid in the middle ear without signs or symptoms of infection. As the aetiology and pathogenesis of the disease are unknown, and as it affects children aged from 3 to 12 years, treatment procedures proposed for management of secretory otitis media, are not uniform. Some authors ...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：INTRODUCTION:Total anomalous pulmonary venous connection (TAPVC) is a rare congenital heart disease and in some variants represents the only true surgical emergency in congenital heart surgery. Basic anatomical characteristic of this anomaly is an abnormal connection of pulmonary veins with systemic venous circulation....
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1404164m
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:The prevalence of obesity is rising to epidemic proportions at the alarming rate in both developed and underdeveloped countries around the world. Current prevalence data from individual national studies suggest that the obesity prevalence in the European countries ranges from 10% to 20% for men, and 10% to...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh0702061g
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:Dyslexia represents a significant pediatric problem requiring prompt and appropriate treatment. OBJECTIVE:The aim of this study was to examine the significance of integral rehabilitation approach in treating dyslexia of children. METHODS:Objectives of the study were accomplished on a sample of 300 childr...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章
doi：10.2298/sarh1210625s
更新日期：2012-09-01 00:00:00
abstract：:Inflammatory response in tissue results from a complex network of interactions between inflammatory cells (mast cells, eosinophils, basophils, macrophages) and resident cells belonging to the lung structure (like endothelial cells, fibroblasts, epithelial cells). Among structural cells, endothelial cells play a critic...
journal_title：Srpski arhiv za celokupno lekarstvo
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
