Drug induced intracranial hypertension associated with sulphasalazine treatment.

Abstract:

:A 25-year-old female patient developed headache and papilledema under sulphasalazine treatment for ulcerative colitis. The patient met the International Headache Society's criteria for idiopathic intracranial hypertension. Sulphasalazine was discontinued and the patient was given azathioprine for ulcerative colitis and acetazolamide for intracranial hypertension. Three weeks later, her examination was normal and lumbar puncture revealed an opening pressure of 180-mm H(2)O. Sulphasalazine is a product of 5 aminosalicylate (5 ASA) and there seems to be a relationship between the administration of sulphasalazine and the onset of intracranial hypertension symptoms. Early diagnosis of intracranial hypertension is important in patients with ulcerative colitis receiving 5 ASA treatment to prevent visual complications.

journal_name

Headache

journal_title

Headache

authors

Sevgi E,Yalcin G,Kansu T,Varli K

doi

10.1111/j.1526-4610.2007.00992.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

296-8

issue

2

eissn

0017-8748

issn

1526-4610

pii

HED992

journal_volume

48

pub_type

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