Predictors of acute treatment response among patients with cluster headache.

Abstract:

BACKGROUND:Oxygen and triptans are drugs of first choice to abort cluster headache attacks. However, clinical predictors of treatment response are unavailable. OBJECTIVE:We aimed to identify predictors of acute treatment response among patients with cluster headache. METHODS:We investigated 246 cluster headache patients with available information on personal, headache, and lifestyle characteristics as well as effectiveness of acute medication use. We used logistic regression models to identify potential predictors of triptan and oxygen response. RESULTS:Triptans were effective in 137 of the 191 users and oxygen in 134 of the 175 users. We only identified increasing age (OR 0.96, 95% CI 0.93-0.99; P= .013) as a negative predictor for triptan response, while nausea/vomiting (OR 0.41, 95% CI 0.18-0.91; P= .029) and restlessness (OR 0.09, 95% CI 0.01-0.66; P= .019) were negative predictors of oxygen response. CONCLUSIONS:Few clinical features seem to predict treatment nonresponse in cluster headache. More refined studies aiming at physiological and genetic characteristics seem promising in the future.

journal_name

Headache

journal_title

Headache

authors

Schürks M,Rosskopf D,de Jesus J,Jonjic M,Diener HC,Kurth T

doi

10.1111/j.1526-4610.2007.00862.x

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

1079-84

issue

7

eissn

0017-8748

issn

1526-4610

pii

HED862

journal_volume

47

pub_type

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