Abstract:
OBJECTIVE:To evaluate whether self-reported past migraine response to reproductive life events (menses, pregnancy, menopause) alters the likelihood of worsening of migraine with exogenous hormone use. METHODS:A retrospective study was conducted on 451 female patients at the University Headache Center who had a diagnosis of migraine with or without aura. RESULTS:The majority of migraineurs recalled no change in headaches with oral contraceptive use or hormone replacement therapy (67.2% and 77%, respectively). Worsening of migraines with oral contraceptive use was associated with a menstrual trigger, worsening during pregnancy, and a diagnosis of migraine without aura. Worsening with hormone replacement therapy was associated with worsening during prior oral contraceptive use, improvement during pregnancy, worsening during menopause, and a diagnosis of migraine without aura. CONCLUSIONS:Prospective studies are needed to confirm these associations.
journal_name
Headachejournal_title
Headacheauthors
Mueller Ldoi
10.1046/j.1526-4610.2000.00027.xkeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
189-93issue
3eissn
0017-8748issn
1526-4610pii
hed00027journal_volume
40pub_type
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