Predictability of exogenous hormone effect on subgroups of migraineurs.

Abstract:

OBJECTIVE:To evaluate whether self-reported past migraine response to reproductive life events (menses, pregnancy, menopause) alters the likelihood of worsening of migraine with exogenous hormone use. METHODS:A retrospective study was conducted on 451 female patients at the University Headache Center who had a diagnosis of migraine with or without aura. RESULTS:The majority of migraineurs recalled no change in headaches with oral contraceptive use or hormone replacement therapy (67.2% and 77%, respectively). Worsening of migraines with oral contraceptive use was associated with a menstrual trigger, worsening during pregnancy, and a diagnosis of migraine without aura. Worsening with hormone replacement therapy was associated with worsening during prior oral contraceptive use, improvement during pregnancy, worsening during menopause, and a diagnosis of migraine without aura. CONCLUSIONS:Prospective studies are needed to confirm these associations.

journal_name

Headache

journal_title

Headache

authors

Mueller L

doi

10.1046/j.1526-4610.2000.00027.x

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

189-93

issue

3

eissn

0017-8748

issn

1526-4610

pii

hed00027

journal_volume

40

pub_type

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