Migraine as a Cortical Brain Disorder.

Abstract:

PURPOSE:Migraine is an exclusively human chronic disorder with ictal manifestations characterized by a multifaceted clinical complexity pointing to a cerebral cortical involvement. The present review is aimed to cover the clinical, neuroimaging, and neurophysiological literature on the role of the cerebral cortex in migraine pathophysiology. OVERVIEW:Converging clinical scenarios, advanced neuroimaging data, and experimental neurophysiological findings, indicate that fluctuating excitability, plasticity, and metabolism of cortical neurons represent the pathophysiological substrate of the migraine cycle. Abnormal cortical responsivity and sensory processing coupled to a mismatch between the brain's energy reserve and workload may ignite the trigeminovascular system, leading to the migraine attack through the activation of subcortical brain trigeminal and extra-trigeminal structures, and driving its propagation and maintenance. DISCUSSION:The brain cortex emerges as the crucial player in migraine, a disorder lying at the intersection between neuroscience and daily life. Migraine disorder stems from an imbalance in inhibitory/excitatory cortical circuits, responsible for functional changes in the activity of different cortical brain regions encompassing the neurolimbic-pain network, and secondarily allowing a demodulation of subcortical areas, such as hypothalamus, amygdala, and brainstem nuclei, in a continuous mutual crosstalk.

journal_name

Headache

journal_title

Headache

authors

Barbanti P,Brighina F,Egeo G,Di Stefano V,Silvestro M,Russo A

doi

10.1111/head.13935

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2103-2114

issue

9

eissn

0017-8748

issn

1526-4610

journal_volume

60

pub_type

杂志文章

相关文献

HEADACHE文献大全
  • Low dose flunarizine in the prophylaxis of migraine.

    abstract::In a period of one year (1990) we selected 40 patients suffering from migraine. For an open randomized study there were 2 groups of patients: the first were treated with 10mg of flunarizine per day and the second with 3 mg per day. The patients were treated for 4 months consecutively. There were 11 drop outs (27.5%): ...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.1992.hed3208390.x

    authors: Bassi P,Brunati L,Rapuzzi B,Alberti E,Mangoni A

    更新日期:1992-09-01 00:00:00

  • Unilateral black hairy tongue in trigeminal neuralgia.

    abstract::Unilateral hairlike discoloration of the tongue is described in a patient with ipsilateral mandibular division trigeminal neuralgia. This unusual physical sign coincided with the patient's painful trigger zone and was attributed to hypertrophy of keratinized filiform papillae, where guarded avoidance of mechanical sti...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2004.04173.x

    authors: Cheshire WP Jr

    更新日期:2004-10-01 00:00:00

  • Methodological issues in studying rates and predictors of migraine progression and remission.

    abstract:BACKGROUND:The progression and remission of migraine and the risk factors that determine the course of illness have been intensively studied for the past decade. METHODS:In this fourth paper in a series of methodological articles, we summarize crucial issues that influence studies of migraine clinical course, and sugg...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12128

    authors: Lipton RB,Penzien DB,Turner DP,Smitherman TA,Houle TT

    更新日期:2013-06-01 00:00:00

  • Ophthalmoplegia with migraine in adults: is it ophthalmoplegic migraine?

    abstract:OBJECTIVE:Ophthalmoplegic migraine (OM) is a rare disorder characterized by recurrent oculomotor nerve palsy in children, following migraine headaches. We report 62 adults, seen consecutively, who developed acute ophthalmoplegia with severe attacks of migraine over a 10-year (1996-2005) period. An overwhelming majority...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2009.01405.x

    authors: Lal V,Sahota P,Singh P,Gupta A,Prabhakar S

    更新日期:2009-06-01 00:00:00

  • Ketamine-Magnesium for Refractory Chronic Cluster Headache: A Case Series.

    abstract:OBJECTIVES:To evaluate the safety and efficacy of ketamine-magnesium combination to reduce attacks in a series of patients with refractory chronic cluster headache (rCCH). BACKGROUND:Refractory chronic cluster headache (CCH) is a rare but highly debilitating condition that needs new treatment options. A previous publi...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.14005

    authors: Moisset X,Giraud P,Meunier E,Condé S,Périé M,Picard P,Pereira B,Ciampi de Andrade D,Clavelou P,Dallel R

    更新日期:2020-11-01 00:00:00

  • Migraine changes with age: IMPACT on migraine classification.

    abstract:OBJECTIVE:To establish if criteria for the diagnosis of migraine change with age and to document the influence of age on the full spectrum of migraine features. Also to define the clinical spectrum and provide a prognostic profile of migraine stratified by age. BACKGROUND:Few studies have formally analyzed migraine ch...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2006.00444.x

    authors: Kelman L

    更新日期:2006-07-01 00:00:00

  • The Impact of Shift Work on Migraine: A Case Series and Narrative Review.

    abstract:OBJECTIVE:We present a case report of 2 migraine patients engaged in shift work, followed by a narrative review, to assess whether shift work influences headache-related disability and chronification of migraine. BACKGROUND:Numerous modifiable factors can lead to chronification of migraine and to higher headache-relat...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/head.13622

    authors: Sandoe CH,Sasikumar S,Lay C,Lawler V

    更新日期:2019-10-01 00:00:00

  • Concepts and mechanisms of migraine chronification.

    abstract::Migraine is a chronic recurrent disorder with episodic manifestations that is progressive in some individuals. Migraine progresses clinically, physiologically, and anatomically. Progression may be a consequence of the mechanisms that generate the migraine attacks (eg, cortical spreading depression) or it may be a func...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/j.1526-4610.2007.00969.x

    authors: Bigal ME,Lipton RB

    更新日期:2008-01-01 00:00:00

  • Cerebrovascular reactivity in adolescents with migraine and tension-type headache during headache-free interval and attack.

    abstract:BACKGROUND:Migraine is a common cause of headache in adolescents. Assuming that the cerebral vasculature is involved in the pathophysiology of migraine, we compared cerebral vasoreactivity in adolescents both during a migraine attack and a headache-free interval. METHODS:A functional transcranial Doppler test utilizin...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2003.03090.x

    authors: Rosengarten B,Sperner J,Görgen-Pauly U,Kaps M

    更新日期:2003-05-01 00:00:00

  • The use of exercise as a method of aborting migraine.

    abstract::Exercise, as a method of migraine management has been discussed theoretically and tested empirically. The consensus is that exercise can help to reduce the frequency, intensity and/or duration of migraine attacks. Conversely, there are case studies which, with few exceptions, suggest that periods of exercise can preci...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1991.hed3109616.x

    authors: Darling M

    更新日期:1991-10-01 00:00:00

  • Characteristics of menstrual vs nonmenstrual migraine: a post hoc, within-woman analysis of the usual-care phase of a nonrandomized menstrual migraine clinical trial.

    abstract:OBJECTIVE:To compare, using a within-woman analysis, the severity, duration, and relapse of menstrual vs nonmenstrual episodes of migraine during treatment with usual migraine therapy. BACKGROUND:Studies comparing the clinical characteristics of menstrual and nonmenstrual migraine attacks have yielded conflicting resu...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1526-4610.2010.01625.x

    authors: MacGregor EA,Victor TW,Hu X,Xiang Q,Puenpatom RA,Chen W,Campbell JC

    更新日期:2010-04-01 00:00:00

  • The Case of the Woman Who Did Never Dare to Fly: Headache Attributed to Imbalance Between Intrasinusal and External Air Pressure.

    abstract:BACKGROUND:A new form of headache, Headache attributed to aeroplane travel (AH), has been recognized within the International Classification of Headache Disorders 3 beta (ICHD-3beta). In 8 out of 85 AH cases we identified the coexistence of a headache with identical features of AH, but appearing during the rapid descen...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12766

    authors: Mainardi F,Maggioni F,Zanchin G

    更新日期:2016-02-01 00:00:00

  • Prevalence and impact of migraine among US Army soldiers deployed in support of Operation Iraqi Freedom.

    abstract:OBJECTIVES:To assess the prevalence and impact of migraine headaches in US Army soldiers deployed in support of Operation Iraqi Freedom. METHODS:A brigade of US Army soldiers stationed at Ft. Lewis, Washingtion was given a self-administered headache questionnaire within 10 days of return from a 1-year combat tour in I...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2008.01159.x

    authors: Theeler BJ,Mercer R,Erickson JC

    更新日期:2008-06-01 00:00:00

  • Prevalence of primary headaches in an urban slum in Enugu South East Nigeria: a door-to-door survey.

    abstract:OBJECTIVE/BACKGROUND:This study aims to determine the prevalence of primary headache disorders using the second edition of international classification of headache disorders among urban slum dwellers. Headache is a common neurological disorder and one of the most common reasons for visiting the neurology clinics in Nig...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12465

    authors: Ezeala-Adikaibe BA,Onyekonwu C,Okudo G,Onodugo O,Ekenze S,Orjioke C,Chime P,Ezeanosike O,Mbadiwe N,Chikani M,Okwara C,Ulasi I,Ijoma U

    更新日期:2014-11-01 00:00:00

  • Ketoprofen, acetaminophen, and placebo in the treatment of tension headache.

    abstract::Seven hundred three subjects completed a randomized, double-blind, parallel-group, single-center study comparing the single-dose efficacy of ketoprofen 12.5 mg, ketoprofen 25 mg, acetaminophen 1000 mg, and placebo in the treatment of tension headache. For the primary efficacy variable, 4-hour sum of pain relief intens...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1526-4610.1998.3808579.x

    authors: Mehlisch DR,Weaver M,Fladung B

    更新日期:1998-09-01 00:00:00

  • Headache after resection of acoustic neuroma.

    abstract::Long-lasting severe headaches are reported to occur in up to 83% of patients who have undergone resection of acoustic neuroma, especially through a suboccipital approach. These headaches, however, are not well defined. The objective of this study was to assess the frequency and character of new-onset headaches after r...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1999.3902089.x

    authors: Mosek AC,Dodick DW,Ebersold MJ,Swanson JW

    更新日期:1999-02-01 00:00:00

  • Episodic acute migraine treatment.

    abstract::The ideal migraine medication would provide rapid “one and done” treatment of migraine for all sufferers. Unfortunately, no such intervention is available. While most people respond to triptans or DHE, some will need to combine these with an NSAID, or will choose to use an NSAID alone because of personal preference or...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12474

    authors: Tepper D

    更新日期:2014-11-01 00:00:00

  • Life event stress and headache frequency revisited.

    abstract::Life stress is found to be related to headache frequency in some studies, but not others. Research designs that find a relationship between the two tend to evaluate young subjects and employ large sample sizes. The purpose of this study was to evaluate the relationship between headache frequency and life stress, while...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2000.00016.x

    authors: Reynolds DJ,Hovanitz CA

    更新日期:2000-02-01 00:00:00

  • Serum concentrations of s100b and NSE in migraine.

    abstract:BACKGROUND:The protein s100b indicates astrocytal damage as well as dysfunction of the blood-brain barrier (BBB), and neuron-specific enolase (NSE) is regarded as a marker for neuronal cell loss. Recently, s100b was shown to be a potentially useful marker for migraine in children. In this study, we investigated the lev...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2008.01228.x

    authors: Teepker M,Munk K,Mylius V,Haag A,Möller JC,Oertel WH,Schepelmann K

    更新日期:2009-02-01 00:00:00

  • Prevention of migraine with olmesartan in patients with hypertension/prehypertension.

    abstract:OBJECTIVE:To explore the effects of olmesartan on frequency and severity of migraine attacks in patients with comorbid hypertension and prehypertension. BACKGROUND:A randomized, double-blind, placebo-controlled, crossover study with a total of 60 patients has demonstrated the efficacy and safety of the angiotensin II ...

    journal_title:Headache

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.2006.00382.x

    authors: Charles JA,Jotkowitz S,Byrd LH

    更新日期:2006-03-01 00:00:00

  • Botulinum toxin for the treatment of chronic migraine: the placebo effect.

    abstract::Botulinum toxin A used to treat headache evokes prominent placebo effects and it is likely that these effects are solely responsible for its apparent effectiveness. ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2011.01915.x

    authors: Solomon S

    更新日期:2011-06-01 00:00:00

  • Long-term tolerability of telcagepant for acute treatment of migraine in a randomized trial.

    abstract:OBJECTIVE:To evaluate the long-term tolerability of telcagepant for acute treatment of intermittent migraine attacks. Background.- Telcagepant is a calcitonin gene-related peptide (CGRP) receptor antagonist being investigated for the acute treatment of migraine. METHODS:Migraine patients were randomized 2:1 to double-...

    journal_title:Headache

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.2010.01799.x

    authors: Connor KM,Aurora SK,Loeys T,Ashina M,Jones C,Giezek H,Massaad R,Williams-Diaz A,Lines C,Ho TW

    更新日期:2011-01-01 00:00:00

  • Tongue necrosis in temporal arteritis.

    abstract::Temporal arteritis is a form of systemic vasculitis that involves branches of the carotid artery. Clinical features are headache, visual loss, ophthalmoplegia, jaw claudication, temporal headache, with tenderness and thickening on the affected temporal artery. We present 3 cases of tongue necrosis due to this granulom...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2007.00890.x

    authors: Goicochea M,Correale J,Bonamico L,Dominguez R,Bagg E,Famulari A,Ameriso S,Sevlever G

    更新日期:2007-09-01 00:00:00

  • Childhood maltreatment and migraine (part III). Association with comorbid pain conditions.

    abstract:OBJECTIVE:To evaluate in a headache clinic population the relationship of childhood maltreatment on the prevalence of pain conditions comorbid with migraine. BACKGROUND:Childhood maltreatment is highly prevalent and has been frequently associated with recurrent headache. The relationship of maltreatment and pain has, ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2009.01558.x

    authors: Tietjen GE,Brandes JL,Peterlin BL,Eloff A,Dafer RM,Stein MR,Drexler E,Martin VT,Hutchinson S,Aurora SK,Recober A,Herial NA,Utley C,White L,Khuder SA

    更新日期:2010-01-01 00:00:00

  • Behavioral dependence in patients with medication overuse headache: a cross-sectional study in consulting patients using the DSM-IV criteria.

    abstract:OBJECTIVE:The aim of this study was to assess behavioral dependence on migraine abortive drugs in medication-overuse headache (MOH) patients and identify the predisposing factors. BACKGROUND:It is common occurrence that MOH patients relapse after medication withdrawal. Behavioral determinants of medication overuse sho...

    journal_title:Headache

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1526-4610.2007.00999.x

    authors: Radat F,Creac'h C,Guegan-Massardier E,Mick G,Guy N,Fabre N,Giraud P,Nachit-Ouinekh F,Lantéri-Minet M

    更新日期:2008-07-01 00:00:00

  • Migraine disability awareness campaign in Asia: migraine assessment for prophylaxis.

    abstract:OBJECTIVES:This study aimed to survey the headache diagnoses and consequences among outpatients attending neurological services in 8 Asian countries. METHODS:This survey recruited patients who consulted neurologists for the first time with the chief complaint of headache. Patients suffering from headaches for 15 or mo...

    journal_title:Headache

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1526-4610.2008.01088.x

    authors: Wang SJ,Chung CS,Chankrachang S,Ravishankar K,Merican JS,Salazar G,Siow C,Cheung RT,Phanthumchinda K,Sakai F

    更新日期:2008-10-01 00:00:00

  • Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications.

    abstract::The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine. However, its efficacy in episodic tension-type headache has not yet be...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1998.3806453.x

    authors: Cerbo R,Barbanti P,Fabbrini G,Pascali MP,Catarci T

    更新日期:1998-06-01 00:00:00

  • Information about migraine disability influences physicians' perceptions of illness severity and treatment needs.

    abstract:OBJECTIVE:To assess physician-patient communication about headache-related disability and to evaluate the influence of information about disability on physicians' perceptions of illness severity and the treatment needs of migraineurs. BACKGROUND:Evidence suggests that migraine is suboptimally treated in clinical pract...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2001.111006343.x

    authors: Holmes WF,MacGregor EA,Sawyer JP,Lipton RB

    更新日期:2001-04-01 00:00:00

  • Olanzapine in the treatment of refractory migraine and chronic daily headache.

    abstract:BACKGROUND:Olanzapine, a thienobenzodiazepine, is a new "atypical" antipsychotic drug. Olanzapine's pharmacologic properties suggest it would be effective for headaches, and its propensity for inducing acute extrapyramidal reactions or tardive dyskinesia is relatively low. We thus decided to assess the value of olanzap...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2002.02126.x

    authors: Silberstein SD,Peres MF,Hopkins MM,Shechter AL,Young WB,Rozen TD

    更新日期:2002-06-01 00:00:00

  • Subcutaneous sumatriptan in cluster headache: a time study of the effect on pain and autonomic symptoms.

    abstract::A subcutaneous injection of 6 mg sumatriptan rapidly and effectively stopped attacks of cluster headache. After a time lag of 4-14 minutes (mean 7 minutes) pain dramatically dropped to zero within seconds to single minutes (mean 56 seconds). This rapid effect may indicate that mere vasoconstriction is the mechanism be...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1993.hed3301018.x

    authors: Hardebo JE

    更新日期:1993-01-01 00:00:00