Zonisamide for migraine prophylaxis in topiramate-intolerant patients: an observational study.

Abstract:

BACKGROUND:Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. METHODS:Tolerability and effectiveness of zonisamide for migraine prophylaxis in patients with a good response to topiramate, but interrupting it for intolerable side effects, were evaluated in 34 patients. After a 1-month period of wash-out, patients were treated with zonisamide (up to a 100 mg/day dosage) for 6 consecutive months. RESULTS:Zonisamide was well tolerated, only 4 (12%) patients reported transient and tolerable side effects. Mean number of days with headache per month was reduced from 14.9 ± 5.3 during the wash-out period to 2.5 ± 0.6 after 6 months of zonisamide (P < .001). We observed a significant reduction in headache severity and disability, as assessed by visual analog scale and migraine disability assessment scale. Finally, when compared with the 1-month period prior to starting zonisamide, a reduced use of analgesics was recorded at the end of the follow-up. CONCLUSION:Our findings support the use of zonisamide as an alternative therapy for migraine prevention in patients with good response, but poor tolerance to topiramate.

journal_name

Headache

journal_title

Headache

authors

Villani V,Ciuffoli A,Prosperini L,Sette G

doi

10.1111/j.1526-4610.2010.01842.x

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

287-91

issue

2

eissn

0017-8748

issn

1526-4610

journal_volume

51

pub_type

杂志文章

相关文献

HEADACHE文献大全
  • Does relaxation treatment have differential effects on migraine and tension-type headache in adolescents?

    abstract::The present study evaluated the effects of relaxation treatment in 36 adolescents aged 13 to 18 years (mean +/- SD, 15.4 +/- 1.55 years) suffering from migraine or migraine and tension-type headache as compared with a waiting-list condition group. The subjects rated various characteristics of migraine and tension-type...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2001.111006290.x

    authors: Fichtel A,Larsson B

    更新日期:2001-03-01 00:00:00

  • Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature.

    abstract:OBJECTIVE:To describe a case series of 7 patients presenting cluster headache (CH) criteria and a substance use disorder, reported to a French Addictovigilance center. Then, to assess clinical, pharmacological, and neurobiological linkages between substance use and CH onset. BACKGROUND:CH patients are presenting a hig...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/head.13516

    authors: Ponté C,Giron A,Crequy M,Lapeyre-Mestre M,Fabre N,Salles J

    更新日期:2019-04-01 00:00:00

  • Looking forward: the end of autonomy.

    abstract::Forecasting how medicine will be practiced 50 years from now presents a challenge. While advances in technology will have a major impact, new cultural outlooks on physician professionalism and autonomy will have an even greater significance in daily practice. The current healthcare system is in crisis. As members of a...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2008.01113.x

    authors: Nash DB,Quigley GD

    更新日期:2008-05-01 00:00:00

  • Double-blind trial of fluoxetine: chronic daily headache and migraine.

    abstract::This study is the first double-blind placebo-controlled trial of fluoxetine for chronic daily headache (CDH) and migraine. After a one month single-blind baseline on placebo, subjects with CDH (n = 64) and migraine (n = 58) were randomly assigned to a three month trial of fluoxetine (20 mg) or an identical placebo. Fl...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.1994.hed3409497.x

    authors: Saper JR,Silberstein SD,Lake AE 3rd,Winters ME

    更新日期:1994-10-01 00:00:00

  • Tongue necrosis in temporal arteritis.

    abstract::Temporal arteritis is a form of systemic vasculitis that involves branches of the carotid artery. Clinical features are headache, visual loss, ophthalmoplegia, jaw claudication, temporal headache, with tenderness and thickening on the affected temporal artery. We present 3 cases of tongue necrosis due to this granulom...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2007.00890.x

    authors: Goicochea M,Correale J,Bonamico L,Dominguez R,Bagg E,Famulari A,Ameriso S,Sevlever G

    更新日期:2007-09-01 00:00:00

  • Faster Improvement in Migraine Pain Intensity and Migraine-Related Disability at Early Time Points with AVP-825 (Sumatriptan Nasal Powder Delivery System) versus Oral Sumatriptan: A Comparative Randomized Clinical Trial Across Multiple Attacks from the CO

    abstract:BACKGROUND:Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administrati...

    journal_title:Headache

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/head.13165

    authors: Lipton RB,McGinley JS,Shulman KJ,Wirth RJ,Buse DC

    更新日期:2017-11-01 00:00:00

  • Examination of unmet treatment needs among persons with episodic migraine: results of the American Migraine Prevalence and Prevention (AMPP) Study.

    abstract:BACKGROUND:Despite the expanding therapeutic armamentarium, many people with episodic migraine (EM) have unmet acute treatment needs. OBJECTIVE:To determine the relative frequency of prespecified types of "unmet treatment needs" in persons with EM in a US population-based sample. METHODS:Eligible participants complet...

    journal_title:Headache

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/head.12154

    authors: Lipton RB,Buse DC,Serrano D,Holland S,Reed ML

    更新日期:2013-09-01 00:00:00

  • Genetic biomarkers for migraine.

    abstract::Biomarkers are physical signs or laboratory measurements that occur in association with a pathological process and have putative diagnostic and/or prognostic utility. In migraine, clinical, radiological, and biochemical biomarkers might be helpful to improve diagnosis, get insight in pathophysiology, and facilitate tr...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/j.1526-4610.2006.00499.x

    authors: De Vries B,Haan J,Frants RR,Van den Maagdenberg AM,Ferrari MD

    更新日期:2006-07-01 00:00:00

  • Pharmacokinetics of tiaprofenic acid after oral administration in fasting patients during and between migraine attacks.

    abstract::This study examined the pharmacokinetics of 300 mg of tiaprofenic acid, a NSAID belonging to the 2-arylpropionic class, as a single oral dose, in 10 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. Drug absorption appeared to be the same du...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1990.hed3010672.x

    authors: Pini LA,Bertolotti M,Bergonzini G,Casalgrandi L,Giroldi L,Sternieri E

    更新日期:1990-10-01 00:00:00

  • Safety and Tolerability of Fremanezumab for the Prevention of Migraine: A Pooled Analysis of Phases 2b and 3 Clinical Trials.

    abstract:OBJECTIVE:Presentation of pooled analysis of safety data for fremanezumab in patients with chronic (CM) or episodic migraine (EM) from 4 placebo-controlled phase 2b and phase 3 studies. BACKGROUND:There is a need for an effective, safe, and well-tolerated preventive therapy that specifically targets the pathophysiolog...

    journal_title:Headache

    pub_type: 杂志文章,meta分析

    doi:10.1111/head.13534

    authors: Silberstein SD,McAllister P,Ning X,Faulhaber N,Lang N,Yeung P,Schiemann J,Aycardi E,Cohen JM,Janka L,Yang R

    更新日期:2019-06-01 00:00:00

  • Respiratory studies in SUNCT syndrome.

    abstract::Seven SUNCT patients (six men, one woman) took part in this study. In four patients, respiratory variables were compared during and outside attacks. In five patients, peripheral chemosensitivity was tested and compared with a control group matched with respect to age, sex, and smoking habits. The results indicate that...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1995.hed3506344.x

    authors: Kruszewski P,White LR,Shen JM,Pareja JA,Zhao JM,Schaanning J,Sjaastad O

    更新日期:1995-06-01 00:00:00

  • Flunarizine versus metoprolol in migraine prophylaxis: a double-blind, randomized parallel group study of efficacy and tolerability.

    abstract::The prophylactic effect of flunarizine and metoprolol was studied in a multi-center randomized, double-blind trial of 149 patients with migraine with or without aura. After a 4-week placebo run-in period, patients were randomly allocated to treatment with flunarizine 10 mg daily or metoprolol 200 mg daily for 16 weeks...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.1991.hed3110650.x

    authors: Sørensen PS,Larsen BH,Rasmussen MJ,Kinge E,Iversen H,Alslev T,Nøhr P,Pedersen KK,Schrøder P,Lademann A

    更新日期:1991-11-01 00:00:00

  • Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications.

    abstract::The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine. However, its efficacy in episodic tension-type headache has not yet be...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1998.3806453.x

    authors: Cerbo R,Barbanti P,Fabbrini G,Pascali MP,Catarci T

    更新日期:1998-06-01 00:00:00

  • Sumatriptan nasal spray in adolescent migraineurs: a randomized, double-blind, placebo-controlled, acute study.

    abstract:OBJECTIVE:To compare the efficacy and tolerability of sumatriptan nasal spray (NS) (5, 20 mg) versus placebo in the acute treatment of migraine in adolescent subjects. BACKGROUND:Currently, no triptan is approved in the United States for the treatment of migraine in adolescent subjects (12 to 17 years). In a previous ...

    journal_title:Headache

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1526-4610.2006.00339.x

    authors: Winner P,Rothner AD,Wooten JD,Webster C,Ames M

    更新日期:2006-02-01 00:00:00

  • Acute demyelination mimicking vascular hemicrania.

    abstract::A 29-year-old woman presented with acute hemicrania, trigeminal neuropathy and posterior fossa dysfunction. The admission differential diagnosis included vertebral artery dissection, posterior circulation aneurysm, vascular malformation and brainstem infarction. However, radiographic and CSF studies indicated demyelin...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1989.hed2907423.x

    authors: Nager BJ,Lanska DJ,Daroff RB

    更新日期:1989-07-01 00:00:00

  • Spontaneous oscillations in cerebral blood flow velocity give evidence of different autonomic dysfunctions in various types of headache.

    abstract:OBJECTIVES:Our objectives were to determine if: (1) patients with migraine have B wave abnormalities in comparison to normal controls and patients with chronic tension headache and (2) patients with chronic tension headache have an imbalance in autonomic activity that is reflected in differences in Mayer wave activity ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:

    authors: Sliwka U,Harscher S,Diehl RR,van Schayck R,Niesen WD,Weiller C

    更新日期:2001-02-01 00:00:00

  • The Case of the Woman Who Did Never Dare to Fly: Headache Attributed to Imbalance Between Intrasinusal and External Air Pressure.

    abstract:BACKGROUND:A new form of headache, Headache attributed to aeroplane travel (AH), has been recognized within the International Classification of Headache Disorders 3 beta (ICHD-3beta). In 8 out of 85 AH cases we identified the coexistence of a headache with identical features of AH, but appearing during the rapid descen...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12766

    authors: Mainardi F,Maggioni F,Zanchin G

    更新日期:2016-02-01 00:00:00

  • Common CX3CR1 alleles are associated with a reduced risk of headaches.

    abstract:OBJECTIVES:The aim of this study was to investigate the role of the chemokine receptor CX3CR1 in headaches and migraine. METHODS:Distribution of 2 polymorphisms of the chemokine receptor CX3CR1 (V249I and T280M) was determined in a population-based sample of 1179 elderly individuals. RESULTS:Heterozygotes for both CX...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2007.01011.x

    authors: Combadière C,Godin O,Vidal C,Cangialosi A,Proust C,Tzourio C

    更新日期:2008-07-01 00:00:00

  • Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women.

    abstract::A retrospective study was conducted on 1300 women suffering from migraine without aura referred to the Headache Centers of Parma and Pavia from 1984 to 1990. All the data concerning their reproductive life, and the modifications induced by it on the course of headache were obtained from record-charts. Migraine frequen...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1993.hed3307385.x

    authors: Granella F,Sances G,Zanferrari C,Costa A,Martignoni E,Manzoni GC

    更新日期:1993-07-01 00:00:00

  • Postoperative headache in acoustic neuroma.

    abstract::Recently, it has become obvious that disabling postoperative headache is a major problem with acoustic neuroma surgery. A questionnaire was used to retrospectively evaluate the incidence, clinical features, prognosis and possible therapeutic measures of this particular form of headache. Forty-two percent (42%) of pati...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1995.hed3502098.x

    authors: Vijayan N

    更新日期:1995-02-01 00:00:00

  • Objectively Measured Physical Activity in Migraine as a Function of Headache Activity.

    abstract:OBJECTIVE:This study sought to compare ambulatory physical activity (PA) between young adults with migraine, tension-type headache (TTH), and non-headache controls and determine if differences in PA were attributable to headache activity or other relevant covariates. BACKGROUND:PA has been implicated in the developmen...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.13921

    authors: Rogers DG,Bond DS,Bentley JP,Smitherman TA

    更新日期:2020-10-01 00:00:00

  • Intravenous lidocaine in the treatment of refractory headache: a retrospective case series.

    abstract:BACKGROUND:New treatments are needed to treat chronic daily headache (CDH) and chronic cluster headache (CCH). New treatments are needed to treat this population and intravenous (IV) lidocaine is a novel treatment for CDH. OBJECTIVE:The aim of this study was to examine the use of IV lidocaine for refractory CDH patien...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2008.01281.x

    authors: Rosen N,Marmura M,Abbas M,Silberstein S

    更新日期:2009-02-01 00:00:00

  • Headache prevalence in adolescents aged 12 to 17: a student-based epidemiological study in Bursa.

    abstract:BACKGROUND AND OBJECTIVES:The objective of this study was to investigate the prevalence and sociodemographic characteristics of headaches among Turkish adolescents aged 12 to 17 years old in Bursa province of Turkey. METHODS:A multistep, stratified, cluster sampling method was used for subject selection. The estimated...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2006.00362.x

    authors: Karli N,Akiş N,Zarifoğlu M,Akgöz S,Irgil E,Ayvacioğlu U,Calişir N,Haran N,Akdoğan O

    更新日期:2006-04-01 00:00:00

  • Serum concentrations of s100b and NSE in migraine.

    abstract:BACKGROUND:The protein s100b indicates astrocytal damage as well as dysfunction of the blood-brain barrier (BBB), and neuron-specific enolase (NSE) is regarded as a marker for neuronal cell loss. Recently, s100b was shown to be a potentially useful marker for migraine in children. In this study, we investigated the lev...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2008.01228.x

    authors: Teepker M,Munk K,Mylius V,Haag A,Möller JC,Oertel WH,Schepelmann K

    更新日期:2009-02-01 00:00:00

  • Tripstar: a comprehensive patient-based approach to compare triptans.

    abstract::Several second-generation triptans have been introduced that differ in their pharmacologic profiles relative to each other and to sumatriptan. As therapeutic options multiply, clinicians must be able to distinguish among these compounds. Recently, a meta-analysis was conducted on data from 53 double-blind, randomized,...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2002.0420s1018.x

    authors: Ferrari MD

    更新日期:2002-01-01 00:00:00

  • The effect of verapamil calcium antagonist on autonomic imbalance in migraine: evaluation by spectral analysis of beat-to-beat heart rate fluctuations.

    abstract::Abnormalities in autonomic control have been documented in migraine even during the headache-free interval. It has long been recognized that spectral analysis of heart rate (HR) fluctuations can reflect the autonomic function, especially the sympathetic to parasympathetic balance. This technique is the basis for a qua...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1994.hed3410569.x

    authors: Zigelman M,Appel S,Davidovitch S,Kuritzky A,Zahavi I,Akselrod S

    更新日期:1994-11-01 00:00:00

  • Repeated doses of combined oral lysine acetylsalicylate and metoclopramide in the acute treatment of migraine.

    abstract::The combination of lysine acetylsalicylate and metoclopramide is effective in the treatment of migraine attacks. It was unknown whether repeated doses could improve efficacy. The aim of this open trial was to evaluate the effects of a second, and eventually a third dose of lysine acetylsalicylate and metoclopramide wh...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1526-4610.1997.3707452.x

    authors: Hugues FC,Lacoste JP,Danchot J,Joire JE

    更新日期:1997-07-01 00:00:00

  • Antihistamine responsive cluster headache in a teenaged girl.

    abstract::Episodic cluster headache is a well-recognized entity usually starting in the second decade of life. Uncommonly, the first typical symptoms may present in the first decade of life, but are rarely recognized as such during childhood. We report a 12-year-old girl who presented with a 1-year history of bouts of right-sid...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1997.3705296.x

    authors: Neubauer D,Kuhar M,Ravnik IM

    更新日期:1997-05-01 00:00:00

  • An epidemiological study of headache among the Monks of Athos (Greece).

    abstract::The Monks of Athos in Greece constitute a particular group with unusual sleep schedule and specific diet. In order to study the frequency of headache among them, a special questionnaire was designed. Four hundred forty-nine monks below the age of 50 were approached, 39 of whom suffered from frequent (more than one epi...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1994.hed3409539.x

    authors: Mitsikostas DD,Thomas A,Gatzonis S,Ilias A,Papageorgiou C

    更新日期:1994-10-01 00:00:00

  • The use of questions to determine the presence of photophobia and phonophobia during migraine.

    abstract:OBJECTIVE:To investigate whether the use of more detailed close-ended questions as part of the routine headache history is helpful when patients initially deny that they are sensitive to light and noise during migraine headaches. BACKGROUND:According to the International Headache Society 2004 criteria, the diagnosis o...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2007.00920.x

    authors: Evans RW,Seifert T,Kailasam J,Mathew NT

    更新日期:2008-03-01 00:00:00