Abstract:
OBJECTIVES:The aim of this study was to investigate the role of the chemokine receptor CX3CR1 in headaches and migraine. METHODS:Distribution of 2 polymorphisms of the chemokine receptor CX3CR1 (V249I and T280M) was determined in a population-based sample of 1179 elderly individuals. RESULTS:Heterozygotes for both CX3CR1 polymorphisms had a reduced risk of recurrent headaches, with an odds ratio (OR) of 0.64 (95% confidence interval [CI] = 0.46-0.90) for the I249 allele and 0.55 (95% CI = 0.38-0.81) for the M280 allele. Haplotype analysis showed that carriers of the rarer CX3CR1 I249-M280 haplotype had a reduced risk of recurrent headaches, with an OR of 0.57 (95% CI = 0.41-0.80, P = .001). This association was seen for both nonmigraine headaches (OR = 0.47, 95% CI = 0.28-0.79, P = .004) and migraine (OR = 0.65, 95% CI = 0.43-0.98, P = .041). CONCLUSIONS:These results need to be replicated but suggest that the chemokine receptor CX3CR1 may play a role in recurrent headaches.
journal_name
Headachejournal_title
Headacheauthors
Combadière C,Godin O,Vidal C,Cangialosi A,Proust C,Tzourio Cdoi
10.1111/j.1526-4610.2007.01011.xsubject
Has Abstractpub_date
2008-07-01 00:00:00pages
1061-6issue
7eissn
0017-8748issn
1526-4610pii
HED1011journal_volume
48pub_type
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