Variation in almotriptan effectiveness according to different prophylactic treatments.

Abstract:

OBJECTIVE:To evaluate the effect of different migraine prophylaxis medications on subject responsiveness to almotriptan. BACKGROUND:There is evidence supporting an increase of responsiveness of symptomatic medications for migraine attacks by some prophylactic treatments although this has not been probed. METHODS:A total of 345 patients (230 women, mean age 37.3) with episodic or chronic migraine were classified according to the prophylaxis they were taking in the following groups: (1) no prophylactic medication; (2) propranolol; (3) topiramate; (4) flunarizine. Decrease in Analogical Visual Scale and pain-free at 2 hours after almotriptan intake was assessed at 2 months. Side effects and discontinuation or treatment were also assessed. RESULTS:Headache severity was reduced 4.2 in control group, 5.3 in propranolol group, 4.1 in topiramate group, and 4.0 in flunarizine group, whereas pain-free status was achieved in 37.3%, 48.7%, 36.1%, and 38.1% respectively. These two parameters were statistically significative between propranolol and control groups. Side effects were similar in all groups. CONCLUSIONS:Our results displayed a higher efficacy of almotriptan in propranolol group and we hypothesized it may be due to a common mechanism of action at serotoninergic receptors.

journal_name

Headache

journal_title

Headache

authors

Bermejo PE,Dorado R,Gomez-Arguelles JM

doi

10.1111/j.1526-4610.2009.01491.x

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1277-82

issue

9

eissn

0017-8748

issn

1526-4610

pii

HED1491

journal_volume

49

pub_type

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