Abstract:
OBJECTIVE:The periaqueductal gray matter (PAG) is at the center of a powerful descending antinociceptive neuronal network. We studied iron homeostasis in the PAG as an indicator of function in patients with episodic migraine (EM) between attacks and patients with chronic daily headache (CDH) during headache. High-resolution magnetic resonance techniques were used to map the transverse relaxation rates R2, R2*, and R2' in the PAG, red nucleus (RN), and substantia nigra (SN). R2' is a measure of non-heme iron in tissues. METHODS:Seventeen patients diagnosed with EM with and without aura, 17 patients diagnosed with CDH and medication overuse, and 17 normal adults (N) were imaged with a 3.0-tesla magnetic resonance imaging system. For each subject, mean values of the relaxation rates, R2 (1/T2), R2* (1/T2*), and R2' (R2* - R2) were obtained for the PAG, RN, and SN. R2, R2*, and R2' values of the EM, CDH, and N groups were compared using analysis of variance, Student t test, and correlation analysis. RESULTS:In the PAG, there was a significant increase in mean R2' and R2* values in both the EM and CDH groups (P<.05) compared with the N group, but no significant difference in these values was demonstrated between the EM and CDH groups, or between those with migraine with or without aura in the EM group. Positive correlations were found for duration of illness with R2' in the EM and CDH groups. A decrease in mean R2' and R2* values also was observed in the RN and SN of the CDH group compared with the N and EM groups (P<.05), explained best by flow activation due to head pain. CONCLUSIONS:Iron homeostasis in the PAG was selectively, persistently, and progressively impaired in the EM and CDH groups, possibly caused by repeated migraine attacks. These results support and emphasize the role of the PAG as a possible "generator" of migraine attacks, potentially by dysfunctional control of the trigeminovascular nociceptive system.
journal_name
Headachejournal_title
Headacheauthors
Welch KM,Nagesh V,Aurora SK,Gelman Ndoi
10.1046/j.1526-4610.2001.041007629.xkeywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
629-37issue
7eissn
0017-8748issn
1526-4610pii
hed01121journal_volume
41pub_type
杂志文章相关文献
HEADACHE文献大全abstract::The responses in cervicogenic headache to four different agents have been studied. Nitroglycerin was given sublingually to 27 patients. Eighteen patients got more than 20% increase of their headache. Of those with any headache increase at all, 12 got bilateral and 12 unilateral pain. The typical late cluster headache ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1993.hed3305249.x
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:This analysis evaluates and ranks efficacy endpoints often used in headache trials concerning their clinical relevance in relation to the patient-related criterion "global assessment of overall efficacy" based on data gained in a large trial investigating different over-the-counter drugs in the treatment of h...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1526-4610.2008.01242.x
更新日期:2009-05-01 00:00:00
abstract::Head pain is the fifth most common reason for emergency department (ED) visits. It is second only to focal weakness as the most common reason for neurological consultation in the ED. This manuscript reviews how patients with migraine, the most common primary headache disorder for which patients seek medical treatment,...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12399
更新日期:2014-07-01 00:00:00
abstract::Recent research on headache has focused on identifying the prevalence of psychiatric disorders in headache patients and discerning the impact of psychiatric comorbidity on treatment of headache. The presence of comorbid psychiatric disorders, especially anxiety and depression, in headache patients is now a well-docume...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2006.00563.x
更新日期:2006-10-01 00:00:00
abstract::Arachnoid cysts are commonly encountered when neuroimaging is obtained for headaches. Their clinical relevance is not always immediately clear and they may confound medical management. ...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12415
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To establish if criteria for the diagnosis of migraine change with age and to document the influence of age on the full spectrum of migraine features. Also to define the clinical spectrum and provide a prognostic profile of migraine stratified by age. BACKGROUND:Few studies have formally analyzed migraine ch...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00444.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of celecoxib for treatment of withdrawal headache vs prednisone in patients with medication overuse headache (MOH). METHODS:In this prospective, double-blind, parallel-group clinical trial, 97 consecutive subjects with MOH were randomized (simple randomization using computer-generated...
journal_title:Headache
pub_type: 杂志文章,随机对照试验
doi:10.1111/head.12487
更新日期:2015-01-01 00:00:00
abstract::Over the past few years, sports-related concussion has received significant media attention making it one of the most, if not highest profile neurological disorder. Thirty-one states now have passed sports concussion laws, with 14 states pending legislation. Most concussions are managed by primary care physicians, ie,...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2012.02138.x
更新日期:2012-05-01 00:00:00
abstract::Chronic drug exposure can induce a significant change in neurotransmitter receptor systems and is possibly involved in the pathogenesis of drug-induced neurological disorders. Abuse of analgesics is known to induce deterioration in headache status in patients with primary headaches, especially migraine. To assess the ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1998.3807534.x
更新日期:1998-07-01 00:00:00
abstract::Recently, it has become obvious that disabling postoperative headache is a major problem with acoustic neuroma surgery. A questionnaire was used to retrospectively evaluate the incidence, clinical features, prognosis and possible therapeutic measures of this particular form of headache. Forty-two percent (42%) of pati...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1995.hed3502098.x
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Migraine is a common cause of headache in adolescents. Assuming that the cerebral vasculature is involved in the pathophysiology of migraine, we compared cerebral vasoreactivity in adolescents both during a migraine attack and a headache-free interval. METHODS:A functional transcranial Doppler test utilizin...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2003.03090.x
更新日期:2003-05-01 00:00:00
abstract::Long-lasting severe headaches are reported to occur in up to 83% of patients who have undergone resection of acoustic neuroma, especially through a suboccipital approach. These headaches, however, are not well defined. The objective of this study was to assess the frequency and character of new-onset headaches after r...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1999.3902089.x
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To investigate the associations between interictal pattern glare, visual stress, and visual triggers of migraine. BACKGROUND:There has been relatively little research on the visual stimuli that can trigger migraine episodes. This is surprising, since if practitioners can obviate such triggers, then some atta...
journal_title:Headache
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1526-4610.2006.00585.x
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Frequent, excessive use of over-the-counter or prescription analgesics may lead to analgesic rebound headache. Little is known about the magnitude of the health problem posed by analgesic rebound headache, its epidemiology, the characteristics of analgesic rebound headache sufferers, or about physicians' app...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3601014.x
更新日期:1996-01-01 00:00:00
abstract::Many patients with migraine believe weather is a trigger for their headaches. The objective of this study was to determine if very low frequency sferics, pulse-shaped electromagnetic fields originating from atmospheric discharges (lightning), are precipitating factors. The occurrence of sferics impulses is characteriz...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00
abstract::Magnetic resonance (MR) angiography was performed during and between two spontaneous and untreated attacks in a 24-year old male patient with episodic cluster headache. The ipsilateral ophthalmic artery was observed to be markedly dilated during both attacks. No changes were seen in the internal carotid artery or any ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1993.hed3306291.x
更新日期:1993-06-01 00:00:00
abstract::The discussion about neuropsychological sequalae from migraine occurring in adults is controversial. The purpose of our study was to examine whether children with migraine may be at risk for impaired intellectual development compared with their siblings free of migraine. ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2002.02179.x
更新日期:2002-09-01 00:00:00
abstract::Patients suffering from cervicogenic headache (CeH) are commonly treated with spinal manipulative therapy. We have analyzed the quality and the outcomes of published, randomized, controlled trials assessing the effectiveness of spinal manipulation in CeH. Among 121 relevant articles, only two met all the inclusion cri...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2005.00253_1.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Migraine can be disabling, but it varies greatly in frequency and intensity between individuals. It is not clear which clinical features have the greatest impact on a migraineur's quality of life. OBJECTIVE:To determine the influence of headache intensity and frequency on headache-related disability. METHO...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2003.03206.x
更新日期:2003-11-01 00:00:00
abstract::We report the case of a 73-year-old woman who presented with right VI nerve palsy and homolateral atypical trigeminal neuralgia; standard neuroradiological investigation of orbital/retroorbital regions and intracranial arteries excluded the most commonly demonstrable underlying causes while brain magnetic resonance (T...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01258.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:Presentation of pooled analysis of safety data for fremanezumab in patients with chronic (CM) or episodic migraine (EM) from 4 placebo-controlled phase 2b and phase 3 studies. BACKGROUND:There is a need for an effective, safe, and well-tolerated preventive therapy that specifically targets the pathophysiolog...
journal_title:Headache
pub_type: 杂志文章,meta分析
doi:10.1111/head.13534
更新日期:2019-06-01 00:00:00
abstract::The efficacy of the repetitive intravenous dihydroergotamine (DHE) inpatient protocol for refractory headache is well established. We conducted a retrospective and prospective study of long-term headache patients at our clinic to evaluate this regimen in an outpatient setting. Treatment consisted of oral metoclopramid...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3209455.x
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Recent studies have found a strong relationship between tobacco smoking and headache pain. It remains unclear whether smoking behavior leads to headache or visa versa, mainly due to the cross-sectional nature of the majority of this research. OBJECTIVE:To help clarify the direction of the relation between s...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2007.01037.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To describe the clinical features of children with chronic daily headache (CDH) and examine the usefulness of the International Classification of Headache Disorders-II. BACKGROUND:Few data are available on chronic daily headache and analgesic overuse in children and adolescents and there are no specific crit...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2005.05137.x
更新日期:2005-06-01 00:00:00
abstract::Seventy-six patients with vascular (migraine or mixed migraine and tension) headache (HA) participated in a controlled evaluation of a minimal-therapist-contact, largely home-based, treatment program which combined relaxation (R) training with thermal biofeedback (TBF). One group received TBF + R administered in 3 off...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.1990.hed3006371.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy and tolerability of sumatriptan nasal spray (NS) (5, 20 mg) versus placebo in the acute treatment of migraine in adolescent subjects. BACKGROUND:Currently, no triptan is approved in the United States for the treatment of migraine in adolescent subjects (12 to 17 years). In a previous ...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1526-4610.2006.00339.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of melatonin as a preventive therapy for hemicrania continua in a larger population of patients than has previously been studied. BACKGROUND:Hemicrania continua is defined by its sensitivity to indomethacin. Rarely can patients be fully tapered off indomethacin without headache recurre...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12489
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Medication-overuse headache (MOH) refers to headache attributed to excessive use of acute medications. The role of personality needs studies to explain the shifting from drug use to drug abuse. The main aim of this study is to study personality, according to Minnesota Multiphasic Personality Inventory, compa...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2011.01978.x
更新日期:2011-09-01 00:00:00
abstract::Unilateral hairlike discoloration of the tongue is described in a patient with ipsilateral mandibular division trigeminal neuralgia. This unusual physical sign coincided with the patient's painful trigger zone and was attributed to hypertrophy of keratinized filiform papillae, where guarded avoidance of mechanical sti...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2004.04173.x
更新日期:2004-10-01 00:00:00
abstract::Epidemiologic studies provide estimates of the scope and distribution of the public health problems posed by migraine. These studies have been facilitated by the development of the International Headache Society criteria for migraine, which have now been used in separate prevalence studies in several countries. In thi...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.1994.hed3406319.x
更新日期:1994-06-01 00:00:00