Abstract:
BACKGROUND:Primary headaches (migraine, tension headache, cluster headache, and other trigeminal autonomic cephalgias) are common in pregnancy and postpartum. It is unclear how to best and most safely manage them. OBJECTIVE:We conducted a systematic review (SR) of interventions to prevent or treat primary headaches in women who are pregnant, attempting to become pregnant, postpartum, or breastfeeding. METHODS:We searched Medline, Embase, Cochrane CENTRAL, CINAHL, ClinicalTrials.gov, Cochrane Database of SRs, and Epistemonikos for primary studies of pregnant women with primary headache and existing SRs of harms in pregnant women regardless of indication. No date or language restrictions were applied. We assessed strength of evidence (SoE) using standard methods. RESULTS:We screened 8549 citations for studies and 2788 citations for SRs. Sixteen studies (mostly high risk of bias) comprising 14,185 patients (total) and 26 SRs met the criteria. For prevention, we found no evidence addressing effectiveness. Antiepileptics, venlafaxine, tricyclic antidepressants, benzodiazepines, β-blockers, prednisolone, and oral magnesium may be associated with fetal/child adverse effects, but calcium channel blockers and antihistamines may not be (1 single-group study and 11 SRs; low-to-moderate SoE). For treatment, combination metoclopramide and diphenhydramine may be more effective than codeine for migraine or tension headache (1 randomized controlled trial; low SoE). Triptans may not be associated with fetal/child adverse effects (8 nonrandomized comparative studies; low SoE). Acetaminophen, prednisolone, indomethacin, ondansetron, antipsychotics, and intravenous magnesium may be associated with fetal/child adverse effects, but low-dose aspirin may not be (indirect evidence; low-to-moderate SoE). We found insufficient evidence regarding non-pharmacologic treatments. CONCLUSIONS:For prevention of primary headache, calcium channel blockers and antihistamines may not be associated with fetal/child adverse effects. For treatment, combination metoclopramide and diphenhydramine may be more effective than codeine. Triptans and low-dose aspirin may not be associated with fetal/child adverse effects. Future research should identify effective and safe interventions in pregnancy and postpartum.
journal_name
Headachejournal_title
Headacheauthors
Saldanha IJ,Cao W,Bhuma MR,Konnyu KJ,Adam GP,Mehta S,Zullo AR,Chen KK,Roth JL,Balk EMdoi
10.1111/head.14041subject
Has Abstractpub_date
2021-01-12 00:00:00eissn
0017-8748issn
1526-4610pub_type
杂志文章,评审相关文献
HEADACHE文献大全abstract:OBJECTIVE:To study the therapeutic potential of the subcutaneous administration of Nalpha-methylhistamine in migraine prophylaxis. BACKGROUND:The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. We consequently considered it viable to conduct a clinical pharmacological stu...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.2003.03074.x
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Although naratriptan is not approved for prophylactic use in migraine, naratriptan has been shown to be significantly more effective than placebo for short-term prevention of menstrually related migraine (MRM). The tolerability of naratriptan administered intermittently for prophylaxis for MRM over the long ...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.2007.00809.x
更新日期:2007-06-01 00:00:00
abstract::A 29-year-old woman presented with acute hemicrania, trigeminal neuropathy and posterior fossa dysfunction. The admission differential diagnosis included vertebral artery dissection, posterior circulation aneurysm, vascular malformation and brainstem infarction. However, radiographic and CSF studies indicated demyelin...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1989.hed2907423.x
更新日期:1989-07-01 00:00:00
abstract::Piroxicam beta-cyclodextrin has recently been observed to be equal to, or even possibly to be superior to, indomethacin (mainly with regard to side effects) in a single case of hemicrania continue. Piroxicam beta-cyclodextrin, 20 to 40 mg per day, was, accordingly, tried in six patients with chronic paroxysmal hemicra...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.1995.hed3509549.x
更新日期:1995-10-01 00:00:00
abstract::Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a ...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.1996.3602091.x
更新日期:1996-02-01 00:00:00
abstract::It has been suggested that magnesium (Mg) may play a role in the pathogenesis of headaches. Serum and intracellular measurements of Mg in headache patients have produced inconsistent results. The recent development of an ion-selective electrode for Mg2+ allowed precise measurement of serum ionized magnesium (IMg2+) in...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1993.hed3303135.x
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and trigeminal neuralgia (TN) are unilateral painful conditions that can share the same triggering factors, autonomic features and the main location, as well as the cyclically recurrent crises. Both these syndromes...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12007
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To determine the brain structures involved in mediating the pain of hemicrania continua using positron emission tomography. BACKGROUND:Hemicrania continua is a strictly unilateral, continuous headache of moderate intensity, with superimposed exacerbations of severe intensity that are accompanied by trigemina...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1526-4610.2004.04141.x
更新日期:2004-09-01 00:00:00
abstract::In order to study the frequency and characteristics of post-angiography headache, we interviewed 45 consecutive patients (mean age +/- SD = 57 +/- 15 years; M/F = 15/30) who underwent transfemoral cerebral angiography for: ischemic cerebrovascular disease (n = 33); suspected arteriovenous malformations (n = 4; one con...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1995.hed3501021.x
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVES:In a randomized controlled trial extending over 6 months, we evaluated the effectiveness of acupuncture versus flunarizine in the prophylactic treatment of migraine without aura. METHODS:One hundred sixty women with migraines were randomly assigned to acupuncture treatment (group A, n = 80) or to an oral th...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1526-4610.2002.02203.x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease who need dialysis often have poor quality of life. Dialysis headache is a frequent complication of hemodialysis and is often a challenge for nephrologists, neurologists, and headache specialists. METHOD:This was a narrative review. RESULTS:The prevalence of dialysis hea...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12875
更新日期:2017-01-01 00:00:00
abstract::The responses in cervicogenic headache to four different agents have been studied. Nitroglycerin was given sublingually to 27 patients. Eighteen patients got more than 20% increase of their headache. Of those with any headache increase at all, 12 got bilateral and 12 unilateral pain. The typical late cluster headache ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1993.hed3305249.x
更新日期:1993-05-01 00:00:00
abstract::The ergot alkaloids are a family of chemical entities that have many pharmacologic effects. Their diversity results from their interaction with multiple receptors, their variable receptor affinity and intrinsic activity, and their variable organ-specific receptor access. Ergotamine tartrate (ET) was one of the first e...
journal_title:Headache
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To understand treatment preferences of people with migraine and the relative importance of improvements in efficacy and avoiding adverse events (AEs), such as cognition problems or weight gain. BACKGROUND:Current preventive migraine medicines are associated with poor adherence and tolerability. There is an u...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13498
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To assess, in the setting of routine clinical practice, rizatriptan's effectiveness in treating acute migraine at its onset versus in a later phase of the attack. BACKGROUND:Although the efficacy and tolerability of rizatriptan have been well documented in clinical trials, no information is available about t...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2002.02008.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To determine if the use of a uniform treatment pathway might be effective in treating patients with primary chronic daily headache. METHODS:Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproe...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.1999.3909650.x
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The protein s100b indicates astrocytal damage as well as dysfunction of the blood-brain barrier (BBB), and neuron-specific enolase (NSE) is regarded as a marker for neuronal cell loss. Recently, s100b was shown to be a potentially useful marker for migraine in children. In this study, we investigated the lev...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01228.x
更新日期:2009-02-01 00:00:00
abstract::A questionnaire study on headaches, using a door-to-door survey, was carried out in a representative sample of the general Greek population, including 1737 men and 1764 women, from 15 to 75 years of age. The parameters evaluated included age, sex, education, socioeconomic status, region of domicile, frequency of heada...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3603168.x
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Zonisamide, a sulfonamide analog, is an antiepileptic drug with mechanisms of action similar to topiramate. Because of its pharmacodynamic and pharmacokinetics profiles, zonisamide is also potentially suitable for migraine prevention. METHODS:Tolerability and effectiveness of zonisamide for migraine prophyl...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2010.01842.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:To assess the measurement properties of the Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQv2.1) electronic patient-reported outcome (ePRO) Role Function-Restrictive (RFR) domain to evaluate the functional impact of migraine in patients with episodic (EM) or chronic migraine (CM) enrolled in...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/head.13497
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Transient headache and neurologic deficits with cerebrospinal fluid lymphocytosis (HaNDL) is benign and self-limited, with neurologic deficits including sensory disturbance of one body side, aphasia, nausea/vomiting, weakness, decreased vision, homonymous hemianopsia, photophobia. Acute confusional state can...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13238
更新日期:2018-03-01 00:00:00
abstract::We report the case of a 60-year-old woman in whom migraine with typical aura heralded the presence of an occipital lobe tumor. Her headache was characterized by recurrent episodes of visual aura confined to the left visual field followed by right hemicranial throbbing headaches accompanied by nausea, photophobia, and ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3601049.x
更新日期:1996-01-01 00:00:00
abstract::Botulinum toxin A used to treat headache evokes prominent placebo effects and it is likely that these effects are solely responsible for its apparent effectiveness. ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2011.01915.x
更新日期:2011-06-01 00:00:00
abstract::It is to be expected that differences in electrical activity of the brain between migraine patients with aura and those without aura can only be revealed by stimuli that provoke visual spatial processing, i.e. stimuli that trigger so called endogenous Visual Evoked Potential (VEP) activity. This is not the case for th...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1993.hed3308413.x
更新日期:1993-09-01 00:00:00
abstract::A case is reported in which a patient with sexual and orgasmic headaches was treated successfully with a calcium channel blocker, diltiazem. To the best of our knowledge, this is the first case of successful treatment of sexual headaches with calcium channel blockers reported in the English medical literature. The lit...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.1991.hed3103141.x
更新日期:1991-03-01 00:00:00
abstract::Biomarkers are physical signs or laboratory measurements that occur in association with a pathological process and have putative diagnostic and/or prognostic utility. In migraine, clinical, radiological, and biochemical biomarkers might be helpful to improve diagnosis, get insight in pathophysiology, and facilitate tr...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2006.00499.x
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:It is commonly known that headaches are induced by intake of specific food, drink, and/or additive. In addition, some patients experience postprandial headache independent of ingestion of specific items. Currently, information on the pathophysiology underlying this particular type of headache is scarce. CAS...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13136
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVES:This study evaluated the long-term safety of oral almotriptan 12.5 mg for the treatment of multiple migraine episodes in adolescents over a 12-month period. Efficacy outcomes were assessed as a secondary objective. METHODS:Adolescent migraineurs aged 12-17 years were enrolled in this 12-month, open-label st...
journal_title:Headache
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1526-4610.2010.01655.x
更新日期:2010-05-01 00:00:00
abstract::Several second-generation triptans have been introduced that differ in their pharmacologic profiles relative to each other and to sumatriptan. As therapeutic options multiply, clinicians must be able to distinguish among these compounds. Recently, a meta-analysis was conducted on data from 53 double-blind, randomized,...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2002.0420s1018.x
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Recurrent headache sufferers are often fearful of pain, which disrupts thought processes, interferes with daily activities, and may maintain headache-related disability through avoidance and associated negative reinforcement. OBJECTIVE:The aim of this cross-sectional study was to (1) examine differences in ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12561
更新日期:2015-05-01 00:00:00