Abstract:
:Biomarkers are physical signs or laboratory measurements that occur in association with a pathological process and have putative diagnostic and/or prognostic utility. In migraine, clinical, radiological, and biochemical biomarkers might be helpful to improve diagnosis, get insight in pathophysiology, and facilitate treatment choices. Genetic biomarkers are defined as genetic variations (mutations or polymorphisms) that can predict disease susceptibility, disease outcome, or treatment response. As yet, only a few genetic biomarkers for migraine are available. Mutations in 3 different genes responsible for familial hemiplegic migraine, a monogenetic subtype of migraine with aura, and the MTHFR C677T polymorphism in common forms of migraine are clear examples. Many positive findings from linkage studies and association studies in common forms of migraine have not been replicated, and are therefore of less clinical use. In this review, we will discuss genetic biomarkers in migraine.
journal_name
Headachejournal_title
Headacheauthors
De Vries B,Haan J,Frants RR,Van den Maagdenberg AM,Ferrari MDdoi
10.1111/j.1526-4610.2006.00499.xsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
1059-68issue
7eissn
0017-8748issn
1526-4610pii
HED499journal_volume
46pub_type
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