Genetic biomarkers for migraine.

Abstract:

:Biomarkers are physical signs or laboratory measurements that occur in association with a pathological process and have putative diagnostic and/or prognostic utility. In migraine, clinical, radiological, and biochemical biomarkers might be helpful to improve diagnosis, get insight in pathophysiology, and facilitate treatment choices. Genetic biomarkers are defined as genetic variations (mutations or polymorphisms) that can predict disease susceptibility, disease outcome, or treatment response. As yet, only a few genetic biomarkers for migraine are available. Mutations in 3 different genes responsible for familial hemiplegic migraine, a monogenetic subtype of migraine with aura, and the MTHFR C677T polymorphism in common forms of migraine are clear examples. Many positive findings from linkage studies and association studies in common forms of migraine have not been replicated, and are therefore of less clinical use. In this review, we will discuss genetic biomarkers in migraine.

journal_name

Headache

journal_title

Headache

authors

De Vries B,Haan J,Frants RR,Van den Maagdenberg AM,Ferrari MD

doi

10.1111/j.1526-4610.2006.00499.x

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1059-68

issue

7

eissn

0017-8748

issn

1526-4610

pii

HED499

journal_volume

46

pub_type

杂志文章,评审

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