Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan.


OBJECTIVE:To determine the pharmacological profile of frovatriptan. BACKGROUND:Frovatriptan is a new 5-HT(1B/1D) agonist developed for the treatment of migraine. METHODS:Pharmacological studies were performed using in vitro and in vivo techniques. RESULTS:Radioligand-binding studies showed that frovatriptan has a high affinity for 5-HT(1B) and 5-HT(1D) receptors, and moderate affinity for 5-HT(1A), 5-HT(1F), and 5-HT(7) receptors. In vitro, frovatriptan acts as a potent full agonist at human cloned 5-HT(1B) and 5-HT(1D) receptors, and as a moderately potent full agonist at 5-HT(7) receptors. Studies of frovatriptan in isolated human arteries demonstrated a lower threshold for constriction of cerebral than coronary vasculature and a bell-shaped dose-response curve was apparent in the coronary arteries. In anesthetized dogs, frovatriptan administration produced no measurable effect on cardiac function or on blood pressure. Frovatriptan had no effects on coronary blood flow following transient coronary artery occlusion, whereas sumatriptan produced a prolonged and significant decrease in coronary blood flow. CONCLUSION:The pharmacology of frovatriptan suggests that it should be an effective agent for the acute treatment of migraine, with a low potential for undesirable peripheral effects.






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Has Abstract


2002-04-01 00:00:00










42 Suppl 2




  • Two studies of the non-pharmacological treatment of menstrually-related migraine headaches.

    abstract::In order to evaluate the effect of non-pharmacological treatment on menstrual and non-menstrual migraine headache (HA), 2 studies have been conducted. In Study 1 which was a retrospective examination of between group reactions to non-drug treatments, 37 self-defined menstrual migraineurs and 62 non-menstrual migraineu...


    pub_type: 杂志文章


    authors: Kim M,Blanchard EB

    更新日期:1992-04-01 00:00:00

  • Access to Triptans for Acute Episodic Migraine: A Qualitative Study.

    abstract:OBJECTIVE:Our study aims to examine factors related to access of triptans among multiple stakeholder groups. BACKGROUND:Triptans are a cornerstone of pain management for the acute treatment of migraine, but actual utilization of triptans is lower than ideal. Initial and continued access to triptans may be an important...


    pub_type: 杂志文章


    authors: Khan S,Mascarenhas A,Moore JE,Knowles S,Gomes T

    更新日期:2015-07-01 00:00:00

  • Chronic bilateral headache responding to indomethacin.

    abstract::Three patients with bilateral chronic tension-type headache (meeting IHS diagnostic criteria) responded with complete control of the headache during the more than 2 years they were treated with indomethacin. The headache recurred within 12 to 26 hours after indomethacin was stopped. Fifty milligrams of intravenous ind...


    pub_type: 杂志文章


    authors: Hannerz J

    更新日期:2000-11-01 00:00:00

  • Hyposerotonin-induced nitric oxide supersensitivity in the cerebral microcirculation.

    abstract:OBJECTIVE:To investigate the relationship between hyposerotonin and cranial microvascular responses to nitric oxide (NO). BACKGROUND:Although the mechanism underlying NO supersensitivity in migraine is still unclear, an alteration of the serotonin system is a possible explanation. METHODS:Wistar rats were divided int...


    pub_type: 杂志文章


    authors: Srikiatkhachorn A,Anuntasethakul T,Maneesri S,Phansuwan-Pujito P,Patumraj S,Kasantikul V

    更新日期:2000-04-01 00:00:00

  • Where SUNCT contacts TN: a case report.

    abstract:BACKGROUND:Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and trigeminal neuralgia (TN) are unilateral painful conditions that can share the same triggering factors, autonomic features and the main location, as well as the cyclically recurrent crises. Both these syndromes...


    pub_type: 杂志文章


    authors: Rinaldi F,Rao R,Venturelli E,Liberini P,Gipponi S,Pari E,Sapia E,Padovani A

    更新日期:2013-10-01 00:00:00

  • Outpatient repetitive intravenous dihydroergotamine.

    abstract::The efficacy of the repetitive intravenous dihydroergotamine (DHE) inpatient protocol for refractory headache is well established. We conducted a retrospective and prospective study of long-term headache patients at our clinic to evaluate this regimen in an outpatient setting. Treatment consisted of oral metoclopramid...


    pub_type: 杂志文章


    authors: Robbins L,Remmes A

    更新日期:1992-10-01 00:00:00

  • One-year follow-up of headache in an adult general population.

    abstract:OBJECTIVE:To investigate variation in headache occurrence and characteristics over 1 year. BACKGROUND:Headache is a common condition which can affect the work, home, and social lives of sufferers, yet surprisingly little is known about how headache changes over time. METHODS:Postal survey to a random general populati...


    pub_type: 杂志文章


    authors: Boardman HF,Thomas E,Millson DS,Croft PR

    更新日期:2005-04-01 00:00:00

  • The trigeminal vasculature pathology in patients with neuralgia.

    abstract:OBJECTIVE:To examine the possible pathological changes of the trigeminal vasculature in patients with neuralgia. BACKGROUND:Such a study has never been performed before. The alterations of the trigeminal vessels could have important pathophysiological implications in the trigeminal neuralgia pathogenesis. METHODS:The...


    pub_type: 杂志文章


    authors: Marinković S,Todorović V,Gibo H,Budec M,Drndarević N,Pesić D,Joković M,Cetković M

    更新日期:2007-10-01 00:00:00

  • One or several types of triptan overuse headaches?

    abstract:BACKGROUND:Whereas the clinical features of pure triptan overuse headache (TOH) are well known, there are insufficient data regarding the semiological pattern of headaches when triptan overuse is associated with other types of medication overuse. OBJECTIVE:To investigate and compare the clinical characteristics of pat...


    pub_type: 杂志文章,多中心研究


    authors: Créac'h C,Radat F,Mick G,Guegan-Massardier E,Giraud P,Guy N,Fabre N,Nachit-Ouinekh F,Lanteri-Minet M

    更新日期:2009-04-01 00:00:00

  • Behavioral dependence in patients with medication overuse headache: a cross-sectional study in consulting patients using the DSM-IV criteria.

    abstract:OBJECTIVE:The aim of this study was to assess behavioral dependence on migraine abortive drugs in medication-overuse headache (MOH) patients and identify the predisposing factors. BACKGROUND:It is common occurrence that MOH patients relapse after medication withdrawal. Behavioral determinants of medication overuse sho...


    pub_type: 杂志文章,多中心研究


    authors: Radat F,Creac'h C,Guegan-Massardier E,Mick G,Guy N,Fabre N,Giraud P,Nachit-Ouinekh F,Lantéri-Minet M

    更新日期:2008-07-01 00:00:00

  • The premonitory phase of migraine--what can we learn from it?

    abstract::This review aims to understand the prevalence of premonitory symptoms in migraine, postulate their mechanisms, and compare these with functional imaging studies. A thorough literature review was conducted using PubMed for prevalence studies of premonitory symptoms in migraine and functional imaging studies in the prem...


    pub_type: 杂志文章,评审


    authors: Maniyar FH,Sprenger T,Monteith T,Schankin CJ,Goadsby PJ

    更新日期:2015-05-01 00:00:00

  • Character of headache in Kimmerle anomaly.

    abstract::The Kimmerle anomaly may be associated with a variety of neurological symptoms. We sought to determine the prevalence and character of these symptoms in a large cohort of afflicted patients. ...


    pub_type: 杂志文章


    authors: Split W,Sawrasewicz-Rybak M

    更新日期:2002-10-01 00:00:00

  • Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications.

    abstract::The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine. However, its efficacy in episodic tension-type headache has not yet be...


    pub_type: 杂志文章


    authors: Cerbo R,Barbanti P,Fabbrini G,Pascali MP,Catarci T

    更新日期:1998-06-01 00:00:00

  • Associations between frequent headaches, persistent smoking, and attempts to quit.

    abstract:BACKGROUND:Recent studies have found a strong relationship between tobacco smoking and headache pain. It remains unclear whether smoking behavior leads to headache or visa versa, mainly due to the cross-sectional nature of the majority of this research. OBJECTIVE:To help clarify the direction of the relation between s...


    pub_type: 杂志文章


    authors: Waldie KE,McGee R,Reeder AI,Poulton R

    更新日期:2008-04-01 00:00:00

  • Persistent trigeminal artery causing "double" neurovascular conflict.

    abstract::We report the case of a 73-year-old woman who presented with right VI nerve palsy and homolateral atypical trigeminal neuralgia; standard neuroradiological investigation of orbital/retroorbital regions and intracranial arteries excluded the most commonly demonstrable underlying causes while brain magnetic resonance (T...


    pub_type: 杂志文章


    authors: Clerici AM,Merlo P,Rognone F,Noce M,Rognone E,Bono G

    更新日期:2009-03-01 00:00:00

  • The role of anger and depression in recurrent headache.

    abstract::Individuals with tension-type headache report significant anger, depression, anxiety, and stressors. However, it is not clear to what extent these variables are interrelated. The objective of the present study was to explore the role of anger in headaches, and to examine its relationship to anxiety, depression, and da...


    pub_type: 杂志文章


    authors: Venable VL,Carlson CR,Wilson J

    更新日期:2001-01-01 00:00:00

  • Management of chronic daily headache utilizing a uniform treatment pathway.

    abstract:OBJECTIVE:To determine if the use of a uniform treatment pathway might be effective in treating patients with primary chronic daily headache. METHODS:Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproe...


    pub_type: 临床试验,杂志文章


    authors: Rothrock JF

    更新日期:1999-10-01 00:00:00

  • Acupuncture for treating acute attacks of migraine: a randomized controlled trial.

    abstract:OBJECTIVE:To discuss the results of a multicenter randomized controlled trial of the efficacy of verum acupuncture in treating acute migraine attacks. BACKGROUND:Acupuncture has been used in China for centuries to treat migraine headache. Convincing evidence of its efficacy in alleviating pain, however, has been inade...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Li Y,Liang F,Yang X,Tian X,Yan J,Sun G,Chang X,Tang Y,Ma T,Zhou L,Lan L,Yao W,Zou R

    更新日期:2009-06-01 00:00:00

  • Prevention of migraine with olmesartan in patients with hypertension/prehypertension.

    abstract:OBJECTIVE:To explore the effects of olmesartan on frequency and severity of migraine attacks in patients with comorbid hypertension and prehypertension. BACKGROUND:A randomized, double-blind, placebo-controlled, crossover study with a total of 60 patients has demonstrated the efficacy and safety of the angiotensin II ...


    pub_type: 杂志文章,随机对照试验


    authors: Charles JA,Jotkowitz S,Byrd LH

    更新日期:2006-03-01 00:00:00

  • Assessment of adverse events associated with triptans--methods of assessment influence the results.

    abstract:BACKGROUND:A recent study conducted in triptan-naive migraine patients showed that tolerability was the second most important attribute of an acute treatment. However, the proportion of patients reporting side effects after any acute treatment may vary with regard to the method of assessment. OBJECTIVES:To contrast tw...


    pub_type: 杂志文章,多中心研究


    authors: Sheftell FD,Feleppa M,Tepper SJ,Rapoport AM,Ciannella L,Bigal ME

    更新日期:2004-11-01 00:00:00

  • Headache in Petrous Apicitis: A Case Report of Chronic Migraine-like Headache Due to Peripheral Pathology.

    abstract:OBJECTIVE:To report a case of petrous apicitis that manifested as chronic migraine without aura and to discuss the pathophysiological mechanisms behind this presentation. BACKGROUND:Petrous apicitis is a rare complication of acute otitis media with varied clinical presentations that stem from the close proximity of th...


    pub_type: 杂志文章


    authors: Mancini AJ,Glassman RD,Chang YM,Burstein R,Ashina S

    更新日期:2019-11-01 00:00:00

  • Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice.

    abstract:OBJECTIVE:A hallmark of migraine is photophobia. In mice, photophobia-like behavior is induced by calcitonin gene-related peptide (CGRP), a neuropeptide known to be a key player in migraine. In this study, we sought to identify sites within the brain from which CGRP could induce photophobia. DESIGN:We focused on the p...


    pub_type: 杂志文章


    authors: Sowers LP,Wang M,Rea BJ,Taugher RJ,Kuburas A,Kim Y,Wemmie JA,Walker CS,Hay DL,Russo AF

    更新日期:2020-10-01 00:00:00

  • Ubrogepant, an Acute Treatment for Migraine, Improved Patient-Reported Functional Disability and Satisfaction in 2 Single-Attack Phase 3 Randomized Trials, ACHIEVE I and II.

    abstract:OBJECTIVE:To evaluate the efficacy of ubrogepant on patient-reported functional disability, satisfaction with study medication, and global impression of change. BACKGROUND:Ubrogepant is a small-molecule, oral calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine. In 2 phase ...


    pub_type: 杂志文章


    authors: Dodick DW,Lipton RB,Ailani J,Halker Singh RB,Shewale AR,Zhao S,Trugman JM,Yu SY,Viswanathan HN

    更新日期:2020-04-01 00:00:00

  • Less Cortical Thickness in Patients With Persistent Post-Traumatic Headache Compared With Healthy Controls: An MRI Study.

    abstract:OBJECTIVE:To investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to interrogate whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH. BACKGROUND:PT...


    pub_type: 杂志文章


    authors: Chong CD,Berisha V,Chiang CC,Ross K,Schwedt TJ

    更新日期:2018-01-01 00:00:00

  • Dihydroergotamine and its use in migraine with posterior fossa symptoms.

    abstract:BACKGROUND:Dihydroergotamine (DHE) has been used for decades to treat migraine, but is currently contraindicated in patients with hemiplegic migraine and basilar-type migraine (BTM). OBJECTIVE:To assess the safety of DHE in patients with symptoms of BTM that do not meet criteria for BTM. METHODS:Retrospective analysi...


    pub_type: 杂志文章


    authors: Whyte CA,Stillman MJ,Tepper SJ

    更新日期:2010-10-01 00:00:00

  • Headache diary in the diagnosis of childhood migraine.

    abstract::The usefulness of a headache diary in the diagnosis of migraine and in the clarification of migraine symptoms was studied in 145 children. These children belong to a 1-year age cohort of 5356 children that has been followed since birth. The children were enrolled in the present study according to their headache status...


    pub_type: 杂志文章


    authors: Metsähonkala L,Sillanpää M,Tuominen J

    更新日期:1997-04-01 00:00:00

  • Predictors of acute treatment response among patients with cluster headache.

    abstract:BACKGROUND:Oxygen and triptans are drugs of first choice to abort cluster headache attacks. However, clinical predictors of treatment response are unavailable. OBJECTIVE:We aimed to identify predictors of acute treatment response among patients with cluster headache. METHODS:We investigated 246 cluster headache patie...


    pub_type: 杂志文章


    authors: Schürks M,Rosskopf D,de Jesus J,Jonjic M,Diener HC,Kurth T

    更新日期:2007-07-01 00:00:00

  • Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine.

    abstract::Forty out-patients affected by chronic tension-type headache were selected according to the diagnostic criteria of International Headache Society (IHS) Headache Classification Committee. In a controlled trial patients received placebo for a four-week baseline period, then they were randomized in double-blind fashion t...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manna V,Bolino F,Di Cicco L

    更新日期:1994-01-01 00:00:00

  • Intracranial hypertension and levofloxacin: a case report.

    abstract::This is a case report of a 15-year-old boy who developed benign intracranial hypertension after 3 weeks of levofloxacin intake. The headache, diplopia, and papilledema resolved within a week after levofloxacin was withdrawn. Physicians must be aware that quinolone antibiotics can potentially cause intracranial hyperte...


    pub_type: 杂志文章


    authors: Lardizabal DV

    更新日期:2009-02-01 00:00:00

  • Mid-cycle headaches and their relationship to different patterns of premenstrual stress symptoms.

    abstract:BACKGROUND:Recent research has shown that affective changes associated with the menstrual cycle may follow diverse patterns, including a classic premenstrual syndrome pattern, as well as the mirror opposite pattern, referred to as a mid-cycle pattern. OBJECTIVE:Test for the presence of a mid-cycle pattern of headaches...


    pub_type: 杂志文章


    authors: Kiesner J,Martin VT

    更新日期:2013-06-01 00:00:00