Reflections and speculations on refractory migraine: why do some patients fail to improve with currently available therapies?

abstract：:Attacks of chronic paroxysmal hemicrania are prevented by the continuous administration of indomethacin. Sumatriptan, an agonist of 5-HT1-like receptors, has proven effective in the treatment of cluster headache attacks. There are clear clinical similarities between chronic paroxysmal hemicrania and cluster headache. ...

journal_title：Headache

authors： Antonaci F,Pareja JA,Caminero AB,Sjaastad O

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The present study endeavored to identify predictors of headache during pregnancy, shortly after delivery, and at 8-week follow-up. BACKGROUND:Many women suffer from headaches during pregnancy and the post-partum period. However, little is known about factors that predict headache surrounding childbirth. MET...

journal_title：Headache

authors： Turner DP,Smitherman TA,Eisenach JC,Penzien DB,Houle TT

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Olanzapine, a thienobenzodiazepine, is a new "atypical" antipsychotic drug. Olanzapine's pharmacologic properties suggest it would be effective for headaches, and its propensity for inducing acute extrapyramidal reactions or tardive dyskinesia is relatively low. We thus decided to assess the value of olanzap...

journal_title：Headache

authors： Silberstein SD,Peres MF,Hopkins MM,Shechter AL,Young WB,Rozen TD

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To evaluate whether self-reported past migraine response to reproductive life events (menses, pregnancy, menopause) alters the likelihood of worsening of migraine with exogenous hormone use. METHODS:A retrospective study was conducted on 451 female patients at the University Headache Center who had a diagnos...

journal_title：Headache

authors： Mueller L

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions. BACKGROUND:Migraine associates with a higher incidence of magnetic resonance imaging (MRI)-visible white matter signal abnormalities. Several attack-related pat...

journal_title：Headache

authors： Aradi M,Schwarcz A,Perlaki G,Orsi G,Kovács N,Trauninger A,Kamson DO,Erdélyi-Bótor S,Nagy F,Nagy SA,Dóczi T,Komoly S,Pfund Z

更新日期：2013-05-01 00:00:00

abstract：:Approximately 18% of all patients referred for a cranial computed tomography complain of headache only. We reviewed 363 consecutive patients in order to assess the value of this examination in the diagnostic approach. Despite the vast number of normal examinations (88.4%), we advocate the routine use of a cranial comp...

journal_title：Headache

authors： Demaerel P,Boelaert I,Wilms G,Baert AL

更新日期：1996-06-01 00:00:00

abstract：:Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications ...

journal_title：Headache

authors： Robbins MS,Tarshish S,Solomon S,Grosberg BM

更新日期：2009-06-01 00:00:00

abstract：PREMISE:Trigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. PROBL...

journal_title：Headache

authors： Weber K

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Headache is commonly reported in patients presenting with orofacial pain. It has only recently been demonstrated that headache-related disability is high in orofacial pain patients. Traumatic life events (TLEs) such as sexual abuse, physical abuse, and post-traumatic stress disorder (PTSD) are also common in...

journal_title：Headache

authors： Branch MA

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of rizatriptan for acute migraine treatment and patient satisfaction with the drug in usual clinical practice settings. BACKGROUND:Although rizatriptan has been shown to effectively relieve migraine symptoms in clinical trials, we wished to assess its utility in typical patient ...

journal_title：Headache

authors： Jamieson D,Cutrer FM,Goldstein J,Dayno J,Hu XH,USMAP Investigators.

更新日期：2003-03-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoc...

journal_title：Headache

authors： Bigal ME,Walter S,Rapoport AM

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between hyposerotonin and cranial microvascular responses to nitric oxide (NO). BACKGROUND:Although the mechanism underlying NO supersensitivity in migraine is still unclear, an alteration of the serotonin system is a possible explanation. METHODS:Wistar rats were divided int...

journal_title：Headache

authors： Srikiatkhachorn A,Anuntasethakul T,Maneesri S,Phansuwan-Pujito P,Patumraj S,Kasantikul V

更新日期：2000-04-01 00:00:00

abstract：:The typical symptom of intracranial hypotension syndrome is orthostatic headache. The headache may also be accompanied by neck pain and stiffness, low backache, radicular symptoms, quadriplegia, interscapular pain, nausea/vomiting, and cranial nerve involvement symptoms (hearing and visual problems, face pain and numb...

journal_title：Headache

authors： Albayram S,Asik M,Hasiloglu ZI,Dikici AS,Erdemli HE,Altintas A

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To describe a standardized methodology for the performance of peripheral nerve blocks (PNBs) in the treatment of headache disorders. BACKGROUND:PNBs have long been employed in the management of headache disorders, but a wide variety of techniques are utilized in literature reports and clinical practice. MET...

journal_title：Headache

authors： Blumenfeld A,Ashkenazi A,Napchan U,Bender SD,Klein BC,Berliner R,Ailani J,Schim J,Friedman DI,Charleston L 4th,Young WB,Robertson CE,Dodick DW,Silberstein SD,Robbins MS

更新日期：2013-03-01 00:00:00

abstract：:Several second-generation triptans have been introduced that differ in their pharmacologic profiles relative to each other and to sumatriptan. As therapeutic options multiply, clinicians must be able to distinguish among these compounds. Recently, a meta-analysis was conducted on data from 53 double-blind, randomized,...

journal_title：Headache

authors： Ferrari MD

更新日期：2002-01-01 00:00:00

abstract：:Clinical and pathophysiological evidences connect migraine and the cerebellum. Literature on documented cerebellar abnormalities in migraine, however, is relatively sparse. Cerebellar involvement may be observed in 4 types of migraines: in the widespread migraine with aura (MWA) and migraine without aura (MWoA) forms;...

journal_title：Headache

authors： Vincent M,Hadjikhani N

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Though symptomatic medication overuse is believed to play a major role in progression from episodic to chronic or transformed migraine (TM), population-based longitudinal data on these agents are limited. OBJECTIVES:To assess the role of specific classes of acute medications in the development of TM in epis...

journal_title：Headache

authors： Bigal ME,Serrano D,Buse D,Scher A,Stewart WF,Lipton RB

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Migraine can be disabling, but it varies greatly in frequency and intensity between individuals. It is not clear which clinical features have the greatest impact on a migraineur's quality of life. OBJECTIVE:To determine the influence of headache intensity and frequency on headache-related disability. METHO...

journal_title：Headache

authors： Magnusson JE,Becker WJ

更新日期：2003-11-01 00:00:00

abstract：:Imaging studies of spontaneous migraine aura have proved challenging because of the episodic and unpredictable nature of migraine attacks. Two patients with signs of acute ischemic stroke were evaluated for thrombolysis and turned out to suffer from familial hemiplegic migraine. It was possible to record the early pha...

journal_title：Headache

authors： Hansen JM,Schytz HW,Larsen VA,Iversen HK,Ashina M

更新日期：2011-09-01 00:00:00

abstract：:A serologically proven case of parainfluenza viral infection was associated with the onset and disappearance of cluster headache. The patient had long-standing migraine that ceased during the cluster headache period and recurred when the latter stopped. Possibly, the virus was neurally transmitted to the trigeminal-au...

journal_title：Headache

authors： Blanchard BM

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:The primary objective of the TEENZ Study (NCT01211145) was to assess the efficacy of zolmitriptan nasal spray in the acute treatment of adolescent migraine patients (ages 12 to 17 years), as measured by the primary outcome variable of pain-free status at 2 hours post-treatment. METHODS:This randomized, doubl...

journal_title：Headache

authors： Winner P,Farkas V,Štillová H,Woodruff B,Liss C,Lillieborg S,Raines S,TEENZ Study Group.

更新日期：2016-07-01 00:00:00

abstract：:The clinical science of migraine headache continues to evolve. Theories of the pathophysiology of migraine have progressed from the early vascular basis of migraine to more complex current theories that emphasize the centrality of neuronal dysfunction. The most recently articulated theory of migraine is the central se...

journal_title：Headache

authors： Dodick D,Silberstein S

更新日期：2006-11-01 00:00:00

abstract：:A patient with chronic daily headaches developed overt signs of Cushing syndrome during treatment with serial occipital nerve block injections. Investigation demonstrated an exogenous source of corticosteroids as the cause of the Cushing syndrome in this patient, thus, implicating the corticosteroid component of the o...

journal_title：Headache

authors： Lavin PJ,Workman R

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Neck muscle nociception mediated by nitric oxide may play a role in the pathophysiology of tension-type headache. OBJECTIVE:The present study addresses the involvement of neuronal nitric oxide synthase (nNOS) in the facilitation of neck muscle nociception after local application of nerve growth factor (NGF)...

journal_title：Headache

authors： Isaak A,Ellrich J

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:This post hoc study investigated the relationship between patient response in terms of migraine headache day reduction and patient-reported outcomes of health-related quality of life (HRQoL) and disability categories. BACKGROUND:Migraine causes considerable disease-related disability and negatively impacts H...

journal_title：Headache

authors： Ford JH,Kurth T,Starling AJ,Ayer DW,Wietecha LA,Port MD,Rettiganti M,Ruff DD

更新日期：2020-11-01 00:00:00

abstract：:Temporal arteritis is a form of systemic vasculitis that involves branches of the carotid artery. Clinical features are headache, visual loss, ophthalmoplegia, jaw claudication, temporal headache, with tenderness and thickening on the affected temporal artery. We present 3 cases of tongue necrosis due to this granulom...

journal_title：Headache

authors： Goicochea M,Correale J,Bonamico L,Dominguez R,Bagg E,Famulari A,Ameriso S,Sevlever G

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and trigeminal neuralgia (TN) are unilateral painful conditions that can share the same triggering factors, autonomic features and the main location, as well as the cyclically recurrent crises. Both these syndromes...

journal_title：Headache

authors： Rinaldi F,Rao R,Venturelli E,Liberini P,Gipponi S,Pari E,Sapia E,Padovani A

更新日期：2013-10-01 00:00:00

abstract：:A 57-year-old woman presented with an escalation of her headaches which ultimately progressed to multiple strokes and death. MRI/MRA demonstrated diffuse vasospasm and other causes of stroke were excluded on premortem investigation and postmortem examination. Reversible MRI abnormalities, vasospasm on angiogram and fa...

journal_title：Headache

authors： Marshall N,Maclaurin WA,Koulouris G

更新日期：2007-02-01 00:00:00

abstract：:We describe a patient with ophthalmoplegic migraine and right abducens nerve palsy, in whom serial magnetic resonance imaging showed a transient, gadolinium-enhancing lesion in the right lower pons, during both headache and the headache-free period. The enhancing linear lesion was felt to represent intraparenchymal fi...

journal_title：Headache

authors： Lee TG,Choi WS,Chung KC

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate variation in headache occurrence and characteristics over 1 year. BACKGROUND:Headache is a common condition which can affect the work, home, and social lives of sufferers, yet surprisingly little is known about how headache changes over time. METHODS:Postal survey to a random general populati...

journal_title：Headache

authors： Boardman HF,Thomas E,Millson DS,Croft PR

更新日期：2005-04-01 00:00:00