Abstract:
:Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoclonal antibodies are being studied for prevention of episodic migraine, and 1 monoclonal antibody is being studied for prevention of chronic migraine. In this review, we discuss the role of CGRP in normal physiology and the consequences of CGRP inhibition for human homeostasis. We then review the current state of development for CGRP-receptor antagonists and CGRP monoclonal antibodies. We close by speculating on the potential clinical role of CGRP antagonism in the acute and preventive treatment of episodic and chronic migraine.
journal_name
Headachejournal_title
Headacheauthors
Bigal ME,Walter S,Rapoport AMdoi
10.1111/head.12179subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1230-44issue
8eissn
0017-8748issn
1526-4610journal_volume
53pub_type
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