Eletriptan for the short-term prophylaxis of cluster headache.

Abstract:

BACKGROUND:A beneficial prophylactic effect from eletriptan 40 mg given to a single patient with cluster headache was observed. OBJECTIVE:To further evaluate the efficacy of eletriptan in the short-term prophylaxis of cluster headache. METHODS:We treated 18 patients; mean age, 40.5 years (standard deviation [SD], 9.9). The number of cluster headache attacks was recorded during a baseline period of 6 days, and during 6 days of treatment with eletriptan 40 mg twice daily. The primary outcome measure was the reduction in the number of attacks during the treatment period. RESULTS:In the 16 patients who completed the study (2 patients were lost to follow-up), the mean total number of attacks decreased from 10.9 (SD, 5.6) during baseline to 6.3 (SD, 3.7) during treatment with eletriptan (P=.01) The reduction in the number of attacks exceeded 50% in 6 patients. CONCLUSION:This small open-label study suggests that eletriptan 40 mg twice daily may be useful for the short-term prophylaxis of cluster headache.

journal_name

Headache

journal_title

Headache

authors

Zebenholzer K,Wöber C,Vigl M,Wessely P

doi

10.1111/j.1526-4610.2004.04079.x

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

361-4

issue

4

eissn

0017-8748

issn

1526-4610

pii

HED04079

journal_volume

44

pub_type

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