Abstract:
OBJECTIVE:To investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to interrogate whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH. BACKGROUND:PTHs are one of the most common symptoms following concussion. In some patients, PTHs continue for longer than three months and are classified as PPTH. This study has two main goals: (1) To delineate the neuropathology of PPTH, by interrogating differences in cortical thickness in patients with PPTH relative to healthy controls. (2) To interrogate potential associations between brain morphology and headache burden in patients with PPTH by examining whether cortical thickness relates to frequency of headaches or years lived with PTH. METHODS:Adults with PPTH diagnosed according to ICHD 3 beta diagnostic criteria and healthy controls underwent brain MRI on a 3 Tesla scanner. Vertex-by-vertex whole brain estimates of cortical thickness were automatically calculated using FreeSurfer v5.3. Differences in cortical thickness in patients with PPTH relative to healthy controls were determined using a general linear model design. Associations were explored between regional clusters where patients with PPTH showed cortical thickness differences compared with healthy controls with headache frequency and years lived with PPTH. RESULTS:This study included 33 patients with PPTH and 33 healthy control subjects (healthy controls: median age = 33.0, IQR = 15.5; patients with PPTH: median age = 36.0, IQR = 20.5; P = .56). Patients with PPTH had less cortical thickness relative to healthy controls in the left and right superior frontal, caudal middle frontal, and precentral cortex as well as less cortical thickness in the right supramarginal, right superior and inferior parietal, and right precuneus region (P < .05, Monte Carlo corrected for multiple comparisons). There were no regions where patients with PPTH had more cortical thickness relative to healthy controls. A correlation analysis of regions that showed less cortical thickness in patients with PPTH demonstrated a negative correlation between left and right superior frontal thickness with headache frequency (P < .05). There was no association between regional cortical thickness and years lived with PPTH. CONCLUSION:Compared with healthy controls, patients with PPTH had less cortical thickness in bilateral frontal regions and right hemisphere parietal regions. For patients with PPTH, more frequent headaches were related to less thickness in the left and right superior frontal regions, potentially indicating that brain morphology changes in the superior frontal regions in patients with PPTH are modified by headache frequency.
journal_name
Headachejournal_title
Headacheauthors
Chong CD,Berisha V,Chiang CC,Ross K,Schwedt TJdoi
10.1111/head.13223subject
Has Abstractpub_date
2018-01-01 00:00:00pages
53-61issue
1eissn
0017-8748issn
1526-4610journal_volume
58pub_type
杂志文章相关文献
HEADACHE文献大全abstract:BACKGROUND:MAP0004 is a novel orally inhaled formulation of dihydroergotamine mesylate (DHE) currently in development that has been clinically observed to provide rapid ( approximately 10 minutes) therapeutic levels of DHE but with lower rates of adverse effects (dizziness, nausea, and paresthesia) compared with intrav...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01510.x
更新日期:2009-11-01 00:00:00
abstract::Paroxysmal headaches often occur in benign headache disorders such as episodic cluster headache, chronic paroxysmal hemicrania (CPH) and episodic paroxysmal hemicrania. We report 2 patients with paroxysmal headaches occurring in association with cerebrovascular disease. The first patient had paroxysmal headaches from ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3202075.x
更新日期:1992-02-01 00:00:00
abstract:OBJECTIVE:To assess, in the setting of routine clinical practice, rizatriptan's effectiveness in treating acute migraine at its onset versus in a later phase of the attack. BACKGROUND:Although the efficacy and tolerability of rizatriptan have been well documented in clinical trials, no information is available about t...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2002.02008.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the geographic location of the United Council for Neurologic Subspecialties (UCNS)-certified headache subspecialists as compared with ratios of expected migraine and chronic migraine populations in the United States. BACKGROUND:The UCNS is a professional medical organization that accredits fellow...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12406
更新日期:2014-09-01 00:00:00
abstract::Approximately 18% of all patients referred for a cranial computed tomography complain of headache only. We reviewed 363 consecutive patients in order to assess the value of this examination in the diagnostic approach. Despite the vast number of normal examinations (88.4%), we advocate the routine use of a cranial comp...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3606347.x
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:This study compared clinical manifestations and audiovestibular function tests among subjects of basilar-type migraine (BtM), definite and probable migrainous vertigo (dMV and pMV), in order to investigate the relationship between them. BACKGROUND:Various diagnostic criteria such as BtM, dMV, and pMV have be...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01283.x
更新日期:2009-03-01 00:00:00
abstract::This work assesses the differences in the thermographic findings in the craniofacial and neck areas between normal individuals and patients with craniofacial pain or headache, and investigates the influence of muscle contraction on such findings. Thermographic records were taken in 10 healthy subjects and 47 patients ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1990.hed3008497.x
更新日期:1990-07-01 00:00:00
abstract::The aim of the present study was to examine the ability of pericranial muscle tenderness and the second exteroceptive suppression period to distinguish chronic tension-type headache sufferers, migraine sufferers, and controls in a young adult population utilizing a blind design. The second exteroceptive suppression pe...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1997.3706368.x
更新日期:1997-06-01 00:00:00
abstract::Forty-six migraineurs and 69 age- and sex-matched controls referred for MRI scans of the brain were evaluated for the incidence of intracranial pathology. Axial long TR/short TE and long TR/long TE and sagittal short TR/short TE scans were performed in all patients. Enhancement with Gd-DTPA was performed in all contro...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3210507.x
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVES:This study evaluated the long-term safety of oral almotriptan 12.5 mg for the treatment of multiple migraine episodes in adolescents over a 12-month period. Efficacy outcomes were assessed as a secondary objective. METHODS:Adolescent migraineurs aged 12-17 years were enrolled in this 12-month, open-label st...
journal_title:Headache
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1526-4610.2010.01655.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Subcutaneous (s.c.) injection of sumatriptan is currently associated with needle aversion in some patients, and sharps disposal issues. OBJECTIVES:To investigate whether a needle-free system can deliver s.c. sumatriptan. If so, to examine whether needle-free administration is bioequivalent to a 26-gauge nee...
journal_title:Headache
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1526-4610.2009.01530.x
更新日期:2009-11-01 00:00:00
abstract:OBJECT:To investigate the rhythmicity of migraine episodes without aura in a pediatric population. METHODS:Time of occurrence of 2517 migraine attacks in 115 children was recorded, by means of a diary, both by hourly and monthly intervals. RESULTS:A significant circadian variation, characterized by a peak in the afte...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00613.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of early acute migraine intervention with almotriptan vs placebo on functional disability and health-related quality of life (HRQoL) indicators. DESIGN/METHODS:In this multicenter, double-blind, parallel-group trial, adults with international classification of headache disorders-def...
journal_title:Headache
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1526-4610.2007.01044.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the prevalence, demographic, clinical features, and possible risk factors for hemodialysis headache (HDH). BACKGROUND:HDH has been recognized for many years, but the pathophysiology of this condition is not known. High arterial blood pressure, decreased serum osmolality,...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00295.x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The sequence and timing of taking migraine medications, whether prescription or over-the-counter, and the patient's response to their treatment, is unknown. OBJECTIVE:To describe the use of, response to, and satisfaction with acute medications for 1 migraine attack. METHODS:We performed a clinic-based surv...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00437.x
更新日期:2006-05-01 00:00:00
abstract::Long-lasting severe headaches are reported to occur in up to 83% of patients who have undergone resection of acoustic neuroma, especially through a suboccipital approach. These headaches, however, are not well defined. The objective of this study was to assess the frequency and character of new-onset headaches after r...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1999.3902089.x
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Migraine is a highly disabling disease affecting a significant proportion of the Australian population. The methylenetetrahydrofolate reductase (MTHFR) C677T variant has been associated with increased levels of homocysteine and risk of migraine with aura (MA). Folic acid (FA), vitamin B6 , and B12 supplement...
journal_title:Headache
pub_type: 杂志文章,随机对照试验
doi:10.1111/head.12490
更新日期:2015-02-01 00:00:00
abstract::Fourteen female volunteers who met diagnostic criteria for migraine headache monitored their headache activity and menstrual distress symptoms for one menstrual cycle. Serum estradiol and progesterone levels, and menstrual distress measures were collected at four points of the menstrual cycle: menstrual, ovulatory, lu...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3206292.x
更新日期:1992-06-01 00:00:00
abstract::In a data base of 1013 patients with chronic headache, 44.1% reported the onset of headaches before the age of 20 (preadult-onset headache) and 55.9% at or after that age (adult-onset headache). Circumstances of headache onset were mentioned significantly more frequently in the latter than in the former group (8.5% ve...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1526-4610.1999.3905317.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine if the use of a uniform treatment pathway might be effective in treating patients with primary chronic daily headache. METHODS:Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproe...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.1999.3909650.x
更新日期:1999-10-01 00:00:00
abstract::Exercise, as a method of migraine management has been discussed theoretically and tested empirically. The consensus is that exercise can help to reduce the frequency, intensity and/or duration of migraine attacks. Conversely, there are case studies which, with few exceptions, suggest that periods of exercise can preci...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1991.hed3109616.x
更新日期:1991-10-01 00:00:00
abstract::Flunarizine plasma concentrations and side effects were evaluated in migraine patients during a 3 month course of prophylactic treatment. Plasma concentrations did not correlate with daily dose (in mg/kg). Mean flunarizine levels were higher in patients showing sleepiness or sedation. Weight gain was independent of pl...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1990.hed3006369.x
更新日期:1990-05-01 00:00:00
abstract::Two sisters with cluster headache were studied with respect to the pupillary responses to instillation into the conjunctival sac of a single drop of a 1% solution of phenylephrine and a 2% solution of tyramine. The changes in pupillary diameters were documented by photographic pupillometry prior to and at 15, 30, 60, ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3607448.x
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:This study evaluated the effectiveness of a single fixed-dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg (sumatriptan-naproxen) using a very early treatment paradigm in migraine patients whose attacks were historically accompanied by cutaneous allodynia. BACKGROUND:Evidence suggests that allodynic mi...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.2011.01992.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the sensitivity of the new International Classification of Headache Disorders-2nd edition (ICHD-II) criteria in the diagnosis of childhood migraine and to propose specific criteria for the diagnosis of childhood migraine. BACKGROUND:In 2004, ICHD-II was adopted by the International Headache Socie...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2005.00260.x
更新日期:2005-11-01 00:00:00
abstract::Verapamil is used mainly in cardiovascular diseases. High-dose verapamil (360-720 mg) is, however, currently the mainstay in the prophylactic treatment of cluster headache. The oral pharmacokinetics are variable. The pharmacodynamic effect of verapamil, the effect on blood pressure, also varies considerably among subj...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2008.01298.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Headache is commonly reported in patients presenting with orofacial pain. It has only recently been demonstrated that headache-related disability is high in orofacial pain patients. Traumatic life events (TLEs) such as sexual abuse, physical abuse, and post-traumatic stress disorder (PTSD) are also common in...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01182.x
更新日期:2009-04-01 00:00:00
abstract::Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a ...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1046/j.1526-4610.1996.3602091.x
更新日期:1996-02-01 00:00:00
abstract::A variety of drugs from diverse pharmacological classes are in use for migraine prevention. Traditionally, they have been discovered by serendipity. Examples include beta-adrenergic blockers, anticonvulsants, tricyclic antidepressants, and serotonin receptor antagonists. The mechanisms of action of migraine preventive...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2007.00677.x
更新日期:2007-04-01 00:00:00
abstract::Many patients with migraine believe weather is a trigger for their headaches. The objective of this study was to determine if very low frequency sferics, pulse-shaped electromagnetic fields originating from atmospheric discharges (lightning), are precipitating factors. The occurrence of sferics impulses is characteriz...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2001-10-01 00:00:00