Evaluation of beta-endorphin secretion in patients suffering from episodic cluster headache.

Abstract:

:In order to obtain data regarding peripheral levels of beta-endorphin in head pain syndromes, we evaluated the plasma beta-endorphin secretory pattern in 12 adult male patients suffering from cluster headache. Blood samples were drawn every 2 hours for a 24-hour period, and in addition at 30-minute intervals for 120 minutes during cluster attacks. The same sampling was repeated during an asymptomatic period. Cluster headache patients showed no significant beta-endorphin circadian rhythm and a delayed acrophase during cluster periods compared with that recorded in the remission period and in normal subjects. Eighteen cluster headache attacks were recorded during the study day, 13 (72%) of which were followed by a significant increase in beta-endorphin levels. No correlation was found between beta-endorphin maximum net increase and intensity and/or duration of pain. These data suggest the hypothesis of a temporary alteration of beta-endorphin circadian secretion, probably related to involvement of neural structures controlling biorhythm pacemakers.

journal_name

Headache

journal_title

Headache

authors

Franceschini R,Leandri M,Gianelli MV,Cataldi A,Bruno E,Rolandi E,Barreca T

doi

10.1046/j.1526-4610.1996.3610603.x

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

603-7

issue

10

eissn

0017-8748

issn

1526-4610

journal_volume

36

pub_type

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