Young Adults With Headaches: The Transition From Adolescents to Adults.


:Migraine is a common condition that for many begins in childhood and may progress over the course of one's life. The transition from adolescence to adulthood is a critical time for those who suffer from migraine and can be marked by a variety of important considerations for the patient and practitioner. Medication choices may be a challenge during adolescent years as Food and Drug Administration (FDA) approved options are few and many more studies are needed to understand the benefits and risks of use of these agents in adolescents. However, as patients transition to adulthood, FDA approved options and the level of evidence improve significantly. Late adolescents may also struggle with a variety of psychiatric comorbidities that may simultaneously create challenges in determining treatment but also open opportunities to manage multiple comorbidities and address underlying depression, anxiety, and behavioral issues. For late adolescent girls, the beginning of sexual activity, onset of gynecologic conditions, or presence of irregular or painful menses may raise questions regarding the use of oral contraceptives (OCs). Given data on the risks of these medications in women with migraine, especially those with aura or those who smoke, important conversations between physicians and their migraine patients can help risk stratify and determine the risk/benefit profile for the potential use of these agents. Much more data are needed to fully understand the transition from adolescence to adulthood for those suffering with migraine and this article seeks to shed light on the limited understanding currently available in established literature.






O'Brien HL,Cohen JM




Has Abstract


2015-11-01 00:00:00














  • Impact of the International Headache Society criteria on the use of neuroimaging for headache diagnosis in a headache clinic.

    abstract:OBJECTIVE:To evaluate the impact of the introduction of the International Headache Society (IHS) criteria on the use of neuroimaging for headache diagnosis in a specialist outpatient center. BACKGROUND:The general indications for neuroimaging in headache are a matter of debate. International Headache Society criteria ...


    pub_type: 杂志文章


    authors: Fabbrini G,Barbanti P,Pascali MP,Lenzi GL,Cerbo R

    更新日期:1999-11-01 00:00:00

  • Vasospasm contributes to monosodium glutamate-induced headache.

    abstract::Consumption of monosodium glutamate has long been considered to precipitate headaches in susceptible patients. In this study the direct effects of glutamate and its metabolite, glutamine, on arterial contractility were examined using rings of rabbit aorta. In a high concentration glutamate caused significant concentra...


    pub_type: 杂志文章


    authors: Merritt JE,Williams PB

    更新日期:1990-09-01 00:00:00

  • Pharmacokinetics of tiaprofenic acid after oral administration in fasting patients during and between migraine attacks.

    abstract::This study examined the pharmacokinetics of 300 mg of tiaprofenic acid, a NSAID belonging to the 2-arylpropionic class, as a single oral dose, in 10 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. Drug absorption appeared to be the same du...


    pub_type: 杂志文章


    authors: Pini LA,Bertolotti M,Bergonzini G,Casalgrandi L,Giroldi L,Sternieri E

    更新日期:1990-10-01 00:00:00

  • Migraine prevalence and some related factors in Turkey.

    abstract:OBJECTIVES:The aim of our study is to determine the prevalence of migraine in Provincial Center of Edirne. METHODS:A systematic random sample of 386 inhabitants over 14 years old were interviewed face to face. Diagnosis of migraine was based on the International Headache Society (IHS) classification. RESULTS:Migraine...


    pub_type: 杂志文章


    authors: Celik Y,Ekuklu G,Tokuç B,Utku U

    更新日期:2005-01-01 00:00:00

  • Long-term, open-label safety study of oral almotriptan 12.5 mg for the acute treatment of migraine in adolescents.

    abstract:OBJECTIVES:This study evaluated the long-term safety of oral almotriptan 12.5 mg for the treatment of multiple migraine episodes in adolescents over a 12-month period. Efficacy outcomes were assessed as a secondary objective. METHODS:Adolescent migraineurs aged 12-17 years were enrolled in this 12-month, open-label st...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Berenson F,Vasconcellos E,Pakalnis A,Mao L,Biondi DM,Armstrong RB

    更新日期:2010-05-01 00:00:00

  • New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report.

    abstract::We present a novel case of a focal stabbing headache sharing features of primary stabbing headache that started and resolved with the onset and resolution of a course of self-limiting peripheral vertigo. The association of onset and improvement of the stabbing headaches support the trigeminal and vestibular reciprocal...


    pub_type: 信件


    authors: Chan TLH,Kim DD,Becker WJ

    更新日期:2018-01-01 00:00:00

  • The safety of sumatriptan and naratriptan in pregnancy: what have we learned?

    abstract:OBJECTIVES:To monitor for a signal of major teratogenicity by determining the risk of all major defects following in utero exposure to sumatriptan and naratriptan. To monitor for unusual patterns of birth defects that might suggest teratogenicity. BACKGROUND:The prevalence of migraine is highest in women of childbeari...


    pub_type: 杂志文章,多中心研究


    authors: Cunnington M,Ephross S,Churchill P

    更新日期:2009-11-01 00:00:00

  • Migraine Progression: A Systematic Review.

    abstract:BACKGROUND:Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of monthly headache days. Because only a subset of individuals with episodic migraine (EM) progress to chronic migraine (CM) over any given time period, understanding the...


    pub_type: 杂志文章


    authors: Buse DC,Greisman JD,Baigi K,Lipton RB

    更新日期:2019-03-01 00:00:00

  • Needle-free subcutaneous sumatriptan (Sumavel DosePro): bioequivalence and ease of use.

    abstract:BACKGROUND:Subcutaneous (s.c.) injection of sumatriptan is currently associated with needle aversion in some patients, and sharps disposal issues. OBJECTIVES:To investigate whether a needle-free system can deliver s.c. sumatriptan. If so, to examine whether needle-free administration is bioequivalent to a 26-gauge nee...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Brandes JL,Cady RK,Freitag FG,Smith TR,Chandler P,Fox AW,Linn L,Farr SJ

    更新日期:2009-11-01 00:00:00

  • Outdoor pollution and headache.

    abstract::The aim of this study was to clarify a possible relationship between pollution and worsening of headache in the industrial city of Turin. From October 1992 to June 1993, we examined a group of 32 patients suffering from various headache types. During these months, they kept a daily record of their headaches and associ...


    pub_type: 杂志文章


    authors: Nattero G,Enrico A

    更新日期:1996-04-01 00:00:00

  • Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine.

    abstract::The responses in cervicogenic headache to four different agents have been studied. Nitroglycerin was given sublingually to 27 patients. Eighteen patients got more than 20% increase of their headache. Of those with any headache increase at all, 12 got bilateral and 12 unilateral pain. The typical late cluster headache ...


    pub_type: 杂志文章


    authors: Bovim G,Sjaastad O

    更新日期:1993-05-01 00:00:00

  • Differences in the personality profile of medication-overuse headache sufferers and drug addict patients: a comparative study using MMPI-2.

    abstract:BACKGROUND:Medication-overuse headache (MOH) refers to headache attributed to excessive use of acute medications. The role of personality needs studies to explain the shifting from drug use to drug abuse. The main aim of this study is to study personality, according to Minnesota Multiphasic Personality Inventory, compa...


    pub_type: 杂志文章


    authors: Galli F,Pozzi G,Frustaci A,Allena M,Anastasi S,Chirumbolo A,Ghiotto N,Guidetti V,Matarrese A,Nappi G,Pazzi S,Quartesan R,Sances G,Tassorelli C

    更新日期:2011-09-01 00:00:00

  • Headache Disorders May Be a Risk Factor for the Development of New Onset Hypothyroidism.

    abstract:OBJECTIVE:To determine whether headache disorders are a risk factor for the development of new onset hypothyroidism. BACKGROUND:Past studies have reported associations between headache disorders and hypothyroidism, but the directionality of the association is unknown. METHODS:This was a longitudinal retrospective coh...


    pub_type: 杂志文章


    authors: Martin AT,Pinney SM,Xie C,Herrick RL,Bai Y,Buckholz J,Martin VT

    更新日期:2017-01-01 00:00:00

  • Alteration of central excitation circuits in chronic headache and analgesic misuse.

    abstract::Central excitatory circuits could be involved in the pathophysiology of pain; particularly, the genesis of chronic pain. The "second pain" is the sensation that follows the initial pain after an appropriate nociceptive stimulus. The second pain is amplified by repeating the stimulus after brief intervals (temporal sum...


    pub_type: 杂志文章


    authors: Fusco BM,Colantoni O,Giacovazzo M

    更新日期:1997-09-01 00:00:00

  • Migraine changes with age: IMPACT on migraine classification.

    abstract:OBJECTIVE:To establish if criteria for the diagnosis of migraine change with age and to document the influence of age on the full spectrum of migraine features. Also to define the clinical spectrum and provide a prognostic profile of migraine stratified by age. BACKGROUND:Few studies have formally analyzed migraine ch...


    pub_type: 杂志文章


    authors: Kelman L

    更新日期:2006-07-01 00:00:00

  • The cerebellum and migraine.

    abstract::Clinical and pathophysiological evidences connect migraine and the cerebellum. Literature on documented cerebellar abnormalities in migraine, however, is relatively sparse. Cerebellar involvement may be observed in 4 types of migraines: in the widespread migraine with aura (MWA) and migraine without aura (MWoA) forms;...


    pub_type: 杂志文章,评审


    authors: Vincent M,Hadjikhani N

    更新日期:2007-06-01 00:00:00

  • Psychiatric comorbidity of migraine.

    abstract::Migraine affects nearly 12% of the adult population in the United States and causes significant lost productivity and decrements in health-related quality of life. The burden of migraine and the challenge in managing it are increased by the comorbid psychiatric conditions that occur in association with it. Studies in ...


    pub_type: 杂志文章


    authors: Hamelsky SW,Lipton RB

    更新日期:2006-10-01 00:00:00

  • Alpha-dihydroergocryptine in the prophylaxis of migraine: a multicenter double-blind study versus flunarizine.

    abstract::This multicenter, double-blind, clinical study was designed to compare the efficacy and safety of alpha-dihydroergocryptine and flunarizine in the prophylaxis of migraine without aura. One hundred thirty-five patients fulfilling the diagnostic criteria of the International Headache Society were enrolled at five neurol...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Bussone G,Cerbo R,Martucci N,Micieli G,Zanferrari C,Grazzi L,Fabbrini G,Cavallini A,Granella F,Ambrosoli L,Mailland F,Poli A,Manzoni G

    更新日期:1999-06-01 00:00:00

  • Central sensitization theory of migraine: clinical implications.

    abstract::The clinical science of migraine headache continues to evolve. Theories of the pathophysiology of migraine have progressed from the early vascular basis of migraine to more complex current theories that emphasize the centrality of neuronal dysfunction. The most recently articulated theory of migraine is the central se...


    pub_type: 杂志文章,评审


    authors: Dodick D,Silberstein S

    更新日期:2006-11-01 00:00:00

  • Future directions in behavioral headache research: applications for an evolving health care environment.

    abstract::Three decades of research has produced effective behavioral treatments for migraine and tension-type headache, yet the full fruition of this research has not been realized. Further development and dissemination of behavioral treatments is needed to impact the large numbers of those with headache who potentially could ...


    pub_type: 杂志文章


    authors: Penzien DB,Rains JC,Lipchik GL,Nicholson RA,Lake AE 3rd,Hursey KG

    更新日期:2005-05-01 00:00:00

  • Association of RAMP1 rs7590387 with the risk of migraine transformation into medication overuse headache.

    abstract:OBJECTIVES/BACKGROUND:We herein investigated the role of polymorphisms in calcitonin gene-related peptide (CGRP)-related genes looking at the association of rs3781719 (T > C) in the calcitonin gene-related polypeptide-alpha (CALCA) gene and of rs3754701 (T > A) and rs7590387 (C > G) at the receptor activity modifying 1...


    pub_type: 杂志文章


    authors: Cargnin S,Pautasso C,Viana M,Sances G,Mittino D,Cantello R,Tassorelli C,Nappi G,Terrazzino S

    更新日期:2015-05-01 00:00:00

  • Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine.

    abstract::Forty out-patients affected by chronic tension-type headache were selected according to the diagnostic criteria of International Headache Society (IHS) Headache Classification Committee. In a controlled trial patients received placebo for a four-week baseline period, then they were randomized in double-blind fashion t...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manna V,Bolino F,Di Cicco L

    更新日期:1994-01-01 00:00:00

  • Thermographic findings in cranio-facial pain.

    abstract::This work assesses the differences in the thermographic findings in the craniofacial and neck areas between normal individuals and patients with craniofacial pain or headache, and investigates the influence of muscle contraction on such findings. Thermographic records were taken in 10 healthy subjects and 47 patients ...


    pub_type: 杂志文章


    authors: Mongini F,Caselli C,Macrì V,Tetti C

    更新日期:1990-07-01 00:00:00

  • Illness Perception and Job Satisfaction in Patients Suffering from Migraine Headaches: Trait Anxiety and Depressive Symptoms as Potential Mediators.

    abstract:BACKGROUND AND OBJECTIVES:Migraine headache is the seventh leading cause of disability worldwide causing adverse outcomes in many aspects of an individual's life. Many psychological aspects affect chronic migraine (CM): illness perception, anxiety, depressive symptoms, and job satisfaction. This observational study aim...


    pub_type: 杂志文章


    authors: Rogante E,Sarubbi S,Lamis DA,Canzonetta V,Sparagna A,De Angelis V,Erbuto D,Martelletti P,Pompili M

    更新日期:2019-01-01 00:00:00

  • Factors associated with triptan use in episodic migraine: results from the American Migraine Prevalence and Prevention Study.

    abstract:BACKGROUND:Though triptans are considered the standard of acute therapy for migraine attacks with headache-related disability, they are used by the minority of potentially eligible persons. Understanding the socio-demographic and headache features that predict triptan use may help to clarify barriers to optimal treatme...


    pub_type: 杂志文章


    authors: Chu MK,Buse DC,Bigal ME,Serrano D,Lipton RB

    更新日期:2012-02-01 00:00:00

  • How effective is melatonin as a preventive treatment for hemicrania continua? A clinic-based study.

    abstract:OBJECTIVE:To assess the efficacy of melatonin as a preventive therapy for hemicrania continua in a larger population of patients than has previously been studied. BACKGROUND:Hemicrania continua is defined by its sensitivity to indomethacin. Rarely can patients be fully tapered off indomethacin without headache recurre...


    pub_type: 杂志文章


    authors: Rozen TD

    更新日期:2015-03-01 00:00:00

  • The prevalence of headache in Greece: correlations to latitude and climatological factors.

    abstract::A questionnaire study on headaches, using a door-to-door survey, was carried out in a representative sample of the general Greek population, including 1737 men and 1764 women, from 15 to 75 years of age. The parameters evaluated included age, sex, education, socioeconomic status, region of domicile, frequency of heada...


    pub_type: 杂志文章


    authors: Mitsikostas DD,Tsaklakidou D,Athanasiadis N,Thomas A

    更新日期:1996-03-01 00:00:00

  • A review of needle-free sumatriptan injection for rapid control of migraine.

    abstract::The treatment of migraine was transformed in 1992 with the introduction of the first triptan-based therapy, subcutaneous (SC) sumatriptan. SC sumatriptan has high efficacy and a rapid onset of action compared with other available triptans and formulations presumably because of its short Tmax, high Cmax, and avoidance ...


    pub_type: 杂志文章,评审


    authors: Rothrock JF,Freitag FG,Farr SJ,Smith EF 3rd

    更新日期:2013-09-01 00:00:00

  • Serum concentrations of s100b and NSE in migraine.

    abstract:BACKGROUND:The protein s100b indicates astrocytal damage as well as dysfunction of the blood-brain barrier (BBB), and neuron-specific enolase (NSE) is regarded as a marker for neuronal cell loss. Recently, s100b was shown to be a potentially useful marker for migraine in children. In this study, we investigated the lev...


    pub_type: 杂志文章


    authors: Teepker M,Munk K,Mylius V,Haag A,Möller JC,Oertel WH,Schepelmann K

    更新日期:2009-02-01 00:00:00

  • Headache disability in orofacial pain patients is related to traumatic life events.

    abstract:BACKGROUND:Headache is commonly reported in patients presenting with orofacial pain. It has only recently been demonstrated that headache-related disability is high in orofacial pain patients. Traumatic life events (TLEs) such as sexual abuse, physical abuse, and post-traumatic stress disorder (PTSD) are also common in...


    pub_type: 杂志文章


    authors: Branch MA

    更新日期:2009-04-01 00:00:00