Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implications.

Abstract:

:The tricyclic antidepressant, amitriptyline, is an effective drug for the treatment of chronic tension-type headache and for other chronic pain syndromes, but it is also effective in the prophylaxis of an episodic type of headache such as migraine. However, its efficacy in episodic tension-type headache has not yet been clarified. We compared the efficacy of amitriptyline (25 mg/day) in 82 nondepressed patients with either chronic or episodic tension-type headache in an open-label study. Amitriptyline significantly reduced (P < 0.05) frequency and duration of headache as well as analgesic consumption in chronic, but not in episodic, tension-type headache. Further placebo-controlled trials, possibly with higher doses of amitriptyline, might confirm if the different pattern of response to amitriptyline can be explained in terms of different involvement of central nociception and of peripheral myofascial factors in the chronic and in the episodic forms of tension-type headache.

journal_name

Headache

journal_title

Headache

authors

Cerbo R,Barbanti P,Fabbrini G,Pascali MP,Catarci T

doi

10.1046/j.1526-4610.1998.3806453.x

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

453-7

issue

6

eissn

0017-8748

issn

1526-4610

journal_volume

38

pub_type

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