The discovery and development of the triptans, a major therapeutic breakthrough.

abstract：OBJECTIVE:To assess the relationship between the phenotype of the "visual snow" syndrome, comorbid migraine, and typical migraine aura on a clinical basis and using functional brain imaging. BACKGROUND:Patients with "visual snow" suffer from continuous TV-static-like tiny flickering dots in the entire visual field. Mo...

journal_title：Headache

authors： Schankin CJ,Maniyar FH,Sprenger T,Chou DE,Eller M,Goadsby PJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Variables that are thought to precipitate migraine or tension-type headache episodes in children hitherto have only been studied using retrospective reports. As such, there is little empirical evidence to support the actual predictive association between presumed headache triggers and actual headache occurre...

journal_title：Headache

authors： Connelly M,Miller T,Gerry G,Bickel J

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:To determine the effect of a sympathetic block at C7 on cluster headache. BACKGROUND:Eleven patients presenting to a pain control unit with cluster headache were included in the study after giving informed consent. METHODS:In all patients, a mixture of 5 mL of 0.5% bupivacaine hydrochloride and 1 cc of meth...

journal_title：Headache

authors： Albertyn J,Barry R,Odendaal CL

更新日期：2004-02-01 00:00:00

abstract：:Two sisters with cluster headache were studied with respect to the pupillary responses to instillation into the conjunctival sac of a single drop of a 1% solution of phenylephrine and a 2% solution of tyramine. The changes in pupillary diameters were documented by photographic pupillometry prior to and at 15, 30, 60, ...

journal_title：Headache

authors： Havelius U,Milos P,Hindfelt B

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To determine the pain intensity of cluster headache through a large survey by comparing it to other painful disorders. Furthermore, to investigate the relationship between maximal pain, autonomic, and other clinical symptoms, as well as demographic attributes of cluster headache. BACKGROUND:The pain of clust...

journal_title：Headache

authors： Burish MJ,Pearson SM,Shapiro RE,Zhang W,Schor LI

更新日期：2020-12-18 00:00:00

abstract：:The history of post-traumatic headache begins in the middle of the 19th century, and its latest iteration has been defined in the International Headache Classification of 2004. Contrary to the latter, there are instances when mild head injury without symptoms or signs of concussion may evoke the pathophysiological cha...

journal_title：Headache

authors： Solomon S

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To confirm the efficacy of rizatriptan 10 mg orally disintegrating tablet (ODT) for the elimination of migraine-associated nausea. BACKGROUND:Pooled studies of rizatriptan analyzing elimination of nausea as a secondary endpoint showed that 65% of rizatriptan patients reported elimination of nausea at 2 hours...

journal_title：Headache

authors： Freitag F,Taylor FR,Hamid MA,Rodgers A,Hustad CM,Ramsey KE,Skobieranda F

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To evaluate triptan use patterns in a large Israeli HMO district. BACKGROUND:Triptans, 5HT(1B/1D) agonists, provide an effective and safe relief of headache and accompanying symptoms during an acute migraine attack. METHOD:We retrospectively reviewed the computerized prescription filling data of 1498 patien...

journal_title：Headache

authors： Ifergane G,Wirguin I,Shvartzman P

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:It has been suggested that homocysteine (Hcy) and the 5'-10'-methylenetetrahydrofolate reductase (MTHFR) C677T variant are implicated in the pathogenesis of migraine. Homocysteine has the potential to damage endothelium and accelerate atherosclerosis. Genetic factors such as the MTHFR C677T polymorphism, and...

journal_title：Headache

authors： Oterino A,Toriello M,Valle N,Castillo J,Alonso-Arranz A,Bravo Y,Ruiz-Alegria C,Quintela E,Pascual J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Despite the high level of individual and societal burden resulting from headache disorders, the National Institutes of Health (NIH) has funded relatively little research on these disorders. OBJECTIVE:The objective of this study was to define current patterns of NIH funding of research on headache disorders....

journal_title：Headache

authors： Schwedt TJ,Shapiro RE

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To characterize adult patients with episodic migraine who achieved 100% response to galcanezumab treatment. BACKGROUND:Galcanezumab is a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide (CGRP) and has demonstrated efficacy in reducing migraine headache days (MHD) in...

journal_title：Headache

authors： Rosen N,Pearlman E,Ruff D,Day K,Jim Nagy A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of melatonin as a preventive therapy for hemicrania continua in a larger population of patients than has previously been studied. BACKGROUND:Hemicrania continua is defined by its sensitivity to indomethacin. Rarely can patients be fully tapered off indomethacin without headache recurre...

journal_title：Headache

authors： Rozen TD

更新日期：2015-03-01 00:00:00

abstract：:We report the case of a man with episodic cluster headache who suffered from severe obstructive sleep apnea (OSA) as well as periodic limb movements during sleep (PLMS). His attacks of headache occurred primarily during sleep being timely to REM sleep as 90 to 120 minutes interval. OSAs were more frequent and prolonge...

journal_title：Headache

authors： Pelin Z,Bozluolcay M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Migraine is frequently comorbid with major depressive disorder, the presence of which confers increased disability and various clinical challenges. METHODS/RESULTS:The present article reviews empirically supported pharmacologic and cognitive-behavioral interventions for depression, as well as the emerging y...

journal_title：Headache

authors： Peck KR,Smitherman TA,Baskin SM

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To describe the relationship between mood/anxiety disorders and migraine headaches emphasizing the frequency of episodes based in a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health. BACKGROUND:It has been suggested that frequency of migraine headaches can be directly associated wi...

journal_title：Headache

authors： Goulart AC,Santos IS,Brunoni AR,Nunes MA,Passos VM,Griep RH,Lotufo PA,Benseñor IM

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To investigate the efficacy and long-term outcome of intravenous prochlorperazine for the treatment of refractory chronic daily headache. BACKGROUND:Unlike dihydroergotamine, the treatment results of intravenous neuroleptics as first-line agents for refractory chronic daily headache have rarely been reporte...

journal_title：Headache

authors： Lu SR,Fuh JL,Juang KD,Wang SJ

更新日期：2000-10-01 00:00:00

abstract：:In order to study the frequency and characteristics of post-angiography headache, we interviewed 45 consecutive patients (mean age +/- SD = 57 +/- 15 years; M/F = 15/30) who underwent transfemoral cerebral angiography for: ischemic cerebrovascular disease (n = 33); suspected arteriovenous malformations (n = 4; one con...

journal_title：Headache

authors： Ramadan NM,Gilkey SJ,Mitchell M,Sawaya KL,Mitsias P

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To assess physician-patient communication about headache-related disability and to evaluate the influence of information about disability on physicians' perceptions of illness severity and the treatment needs of migraineurs. BACKGROUND:Evidence suggests that migraine is suboptimally treated in clinical pract...

journal_title：Headache

authors： Holmes WF,MacGregor EA,Sawyer JP,Lipton RB

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To assess the degree of debilitation and the treatment views of individuals with headache presenting to a community pharmacy. BACKGROUND:Migraine and chronic daily headache are common poorly managed illnesses. Pharmacists recommend an over-the-counter "headache product" to customers more than 53 000 times da...

journal_title：Headache

authors： Wenzel RG,Schommer JC,Marks TG

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE AND BACKGROUND:Serotonergic mechanisms play an important role in the pathogenesis of headache. To search for potential indicators of altered serotonin homeostasis in migraine, we have investigated three parameters of the platelet serotonin (5HT) system, platelet serotonin level (PSL), platelet serotonin uptak...

journal_title：Headache

authors： Jernej B,Vladić A,Cicin-Sain L,Hranilović D,Banović M,Balija M,Bilić E,Sucić Z,Vukadin S,Grgicević D

更新日期：2002-07-01 00:00:00

abstract：:Observations including the long-recognized tendency of migraine to run in families, the high concordance rates for migraine in twins reared together or apart, and the association of specific mutations with a rare migraine form are consistent with a genetic contribution to the disorder. This paper summarizes major find...

journal_title：Headache

authors： Gardner KL

更新日期：2006-06-01 00:00:00

abstract：:The aim of this study was to clarify a possible relationship between pollution and worsening of headache in the industrial city of Turin. From October 1992 to June 1993, we examined a group of 32 patients suffering from various headache types. During these months, they kept a daily record of their headaches and associ...

journal_title：Headache

authors： Nattero G,Enrico A

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Recent research has shown that affective changes associated with the menstrual cycle may follow diverse patterns, including a classic premenstrual syndrome pattern, as well as the mirror opposite pattern, referred to as a mid-cycle pattern. OBJECTIVE:Test for the presence of a mid-cycle pattern of headaches...

journal_title：Headache

authors： Kiesner J,Martin VT

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:In this study, we explored the relationship between migraine and sport in a physically active population of students, analyzing the risk of migraine among sporty students. BACKGROUND:The relationship between sport and migraine is controversial; moreover, several studies report on sport as a migraine trigger,...

journal_title：Headache

authors： Pilati L,Battaglia G,Di Stefano V,Di Marco S,Torrente A,Raieli V,Firenze A,Salemi G,Brighina F

更新日期：2020-11-01 00:00:00

abstract：:Pain has been considered as part of a defensive strategy whose specific role is to signal an immediate active danger to the organism. This definition fits well for acute pain. It does not work well, however, for chronic pain that is maintained even in absence of an ongoing, active threat. Currently, acute and chronic ...

journal_title：Headache

authors： Bussone G,Grazzi L,Panerai AE

更新日期：2012-10-01 00:00:00

abstract：:Neurotologic symptoms are common with migraine, yet relatively little is known about the pathophysiology of such symptoms. Motion sensitivity with bouts of motion sickness occurs in about two thirds of patients with migraine. Episodes of vertigo occur in about one fourth of patients and, in some, vertigo is the only s...

journal_title：Headache

authors： Baloh RW

更新日期：1997-11-01 00:00:00

abstract：:The CBF studies performed so far during attacks of migraine, may be interpreted as favouring "the vascular theory." This applies to migraine with aura as well as to migraine without aura. Migraine without aura may be due to mild focal CBF reduction--too mild to be detected by the available CBF techniques (i.e. 20% or ...

journal_title：Headache

authors： Skyhøj Olsen T

更新日期：1990-04-01 00:00:00

abstract：:We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induce...

journal_title：Headache

authors： Rozen TD,Saper JR,Sheftell FD,Dodick DW

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:To describe the occurrence of cerebral venous thrombosis in a 40-year-old man whose cerebral event was induced by a poor golf swing, to review the literature on possible mechanisms producing venous thrombosis, and to compare this case with the literature. BACKGROUND:Headache is the most frequent symptom in ...

journal_title：Headache

authors： Saneto RP,Samples S,Kinkel RP

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:This study examined somatic, psychological, and cognitive functioning of subjects with posttraumatic headache in comparison with multiple control groups. BACKGROUND:Posttraumatic headache is not as widely studied as other forms of headache (eg, tension-type, migraine). Previous research has suggested poor ps...

journal_title：Headache

authors： Tatrow K,Blanchard EB,Hickling EJ,Silverman DJ

更新日期：2003-07-01 00:00:00