Clomiphene citrate as a new treatment for SUNCT: hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias.

Abstract:

:We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

journal_name

Headache

journal_title

Headache

authors

Rozen TD,Saper JR,Sheftell FD,Dodick DW

doi

10.1111/j.1526-4610.2005.05143_2.x

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

754-6

issue

6

eissn

0017-8748

issn

1526-4610

pii

HED05143_2

journal_volume

45

pub_type

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