Flunarizine in migraine: a minireview.

Abstract:

:Flunarizine is a non-selective calcium antagonist. It distributes preferentially in the adipose tissue and passes the blood brain barrier. Numerous controlled clinical studies have established that flunarizine is efficacious in migraine prophylaxis, including double-blind studies in which the drug was compared with placebo or other antimigraine drugs. To avoid side effects a special schedule or administration is necessary. Flunarizine has no myogenic effect on smooth muscle cells of the vessles. It is said to be the only calcium antagonist able to protect brain cells against hypoxic damage. In addition, the considerable body of information which shows flunarizine capable of directly influencing the central nervous system, suggests that the drug's anti-migraine action may depend on its ability to influence central phenomena.

journal_name

Headache

journal_title

Headache

authors

Leone M,Grazzi L,La Mantia L,Bussone G

doi

10.1111/j.1526-4610.1991.hed3106388.x

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

388-91

issue

6

eissn

0017-8748

issn

1526-4610

journal_volume

31

pub_type

临床试验,杂志文章,随机对照试验,评审

相关文献

HEADACHE文献大全
  • Migraine Progression: A Systematic Review.

    abstract:BACKGROUND:Migraine is a common and often debilitating neurological disease. It can be divided into episodic and chronic subforms based on the number of monthly headache days. Because only a subset of individuals with episodic migraine (EM) progress to chronic migraine (CM) over any given time period, understanding the...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.13459

    authors: Buse DC,Greisman JD,Baigi K,Lipton RB

    更新日期:2019-03-01 00:00:00

  • Prevalence of primary headaches in an urban slum in Enugu South East Nigeria: a door-to-door survey.

    abstract:OBJECTIVE/BACKGROUND:This study aims to determine the prevalence of primary headache disorders using the second edition of international classification of headache disorders among urban slum dwellers. Headache is a common neurological disorder and one of the most common reasons for visiting the neurology clinics in Nig...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12465

    authors: Ezeala-Adikaibe BA,Onyekonwu C,Okudo G,Onodugo O,Ekenze S,Orjioke C,Chime P,Ezeanosike O,Mbadiwe N,Chikani M,Okwara C,Ulasi I,Ijoma U

    更新日期:2014-11-01 00:00:00

  • The prevalence of headache in Greece: correlations to latitude and climatological factors.

    abstract::A questionnaire study on headaches, using a door-to-door survey, was carried out in a representative sample of the general Greek population, including 1737 men and 1764 women, from 15 to 75 years of age. The parameters evaluated included age, sex, education, socioeconomic status, region of domicile, frequency of heada...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1996.3603168.x

    authors: Mitsikostas DD,Tsaklakidou D,Athanasiadis N,Thomas A

    更新日期:1996-03-01 00:00:00

  • Improvement of decreased critical flicker frequency (CFF) in headache patients with drug abuse after successful withdrawal.

    abstract::A considerable proportion of headache patients fulfill the criteria of "drug abuse" (definition according to the International Headache Society [IHS] criteria). These patients exhibit markedly reduced vigilance and continuous performance, as shown by the results of critical flicker frequency (CFF) analysis. The presen...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1995.hed3505269.x

    authors: Schnider P,Maly J,Grünberger J,Aull S,Zeiler K,Wessely P

    更新日期:1995-05-01 00:00:00

  • Dihydroergotamine and its use in migraine with posterior fossa symptoms.

    abstract:BACKGROUND:Dihydroergotamine (DHE) has been used for decades to treat migraine, but is currently contraindicated in patients with hemiplegic migraine and basilar-type migraine (BTM). OBJECTIVE:To assess the safety of DHE in patients with symptoms of BTM that do not meet criteria for BTM. METHODS:Retrospective analysi...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2010.01698.x

    authors: Whyte CA,Stillman MJ,Tepper SJ

    更新日期:2010-10-01 00:00:00

  • Neuronal nitric oxide synthase is involved in the induction of nerve growth factor-induced neck muscle nociception.

    abstract:BACKGROUND:Neck muscle nociception mediated by nitric oxide may play a role in the pathophysiology of tension-type headache. OBJECTIVE:The present study addresses the involvement of neuronal nitric oxide synthase (nNOS) in the facilitation of neck muscle nociception after local application of nerve growth factor (NGF)...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2011.01854.x

    authors: Isaak A,Ellrich J

    更新日期:2011-05-01 00:00:00

  • Familial hemiplegic migraine with crossed cerebellar diaschisis and unilateral meningeal enhancement.

    abstract::A 6-year-old boy with a family history of hemiplegic migraine had a hemiplegic migraine lasting for 6 days complicated by prolonged fever, lethargy, and two brief focal seizures. An acute single photon emission computerized tomogram (SPECT) demonstrated decreased blood flow in the symptomatic cerebral hemisphere as we...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1997.3709590.x

    authors: Crawford JS,Konkol RJ

    更新日期:1997-10-01 00:00:00

  • A history of cigarette smoking is associated with the development of cranial autonomic symptoms with migraine headaches.

    abstract:OBJECTIVE:To look at the smoking history of migraine patients and to determine if a history of cigarette smoking is associated with the development of cranial autonomic symptoms with migraine headaches. BACKGROUND:It has recently been noted that a significant number of migraine patients may develop autonomic symptoms ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2010.01707.x

    authors: Rozen TD

    更新日期:2011-01-01 00:00:00

  • Headache and sferics.

    abstract::Many patients with migraine believe weather is a trigger for their headaches. The objective of this study was to determine if very low frequency sferics, pulse-shaped electromagnetic fields originating from atmospheric discharges (lightning), are precipitating factors. The occurrence of sferics impulses is characteriz...

    journal_title:Headache

    pub_type: 杂志文章

    doi:

    authors: Vaitl D,Propson N,Stark R,Walter B,Schienle A

    更新日期:2001-10-01 00:00:00

  • Brainstem dysfunction in chronic migraine as evidenced by neurophysiological and positron emission tomography studies.

    abstract:BACKGROUND:The pathophysiology of chronic migraine (CM) is not fully understood. We aimed to examine transcranial magnetic stimulation (TMS) indices of cortical excitability in patients with CM and also performed PET studies to ascertain if there were any areas of activation and inhibition for possible correlation. ME...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2007.00853.x

    authors: Aurora SK,Barrodale PM,Tipton RL,Khodavirdi A

    更新日期:2007-07-01 00:00:00

  • beta-endorphin in plasma and monocytes in juvenile headache.

    abstract::Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a ...

    journal_title:Headache

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1526-4610.1996.3602091.x

    authors: Battistella PA,Bordin A,Cernetti R,Broetto S,Corrà S,Piva E,Plebani M

    更新日期:1996-02-01 00:00:00

  • Factors Associated with Primary Headache According to Diagnosis, Sex, and Social Group.

    abstract:BACKGROUND:We previously showed that migraine and tension-type headache (TTH) have a high prevalence that differs markedly between social groups. Here, we aim to identify factors associated with migraine and TTH (possible risk factors) in three social groups to better understand the difference in prevalence between sex...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12757

    authors: Lebedeva ER,Kobzeva NR,Gilev DV,Olesen J

    更新日期:2016-02-01 00:00:00

  • Chronic tension-type headache, mood depression and serotonin: therapeutic effects of fluvoxamine and mianserine.

    abstract::Forty out-patients affected by chronic tension-type headache were selected according to the diagnostic criteria of International Headache Society (IHS) Headache Classification Committee. In a controlled trial patients received placebo for a four-week baseline period, then they were randomized in double-blind fashion t...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1526-4610.1994.hed3401044.x

    authors: Manna V,Bolino F,Di Cicco L

    更新日期:1994-01-01 00:00:00

  • Misdiagnosis of Spontaneous Intracranial Hypotension as a Risk Factor for Subdural Hematoma.

    abstract:OBJECTIVE:This study aimed to evaluate the association between misdiagnosis of spontaneous intracranial hypotension (SIH) and subdural hematoma development. BACKGROUND:Although SIH is more prevalent than expected and causes potentially life-threatening complications including subdural hematoma (SDH), the association b...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.13132

    authors: Kim YJ,Cho HY,Seo DW,Sohn CH,Ahn S,Lee YS,Kim WY,Lim KS

    更新日期:2017-11-01 00:00:00

  • Predictability of exogenous hormone effect on subgroups of migraineurs.

    abstract:OBJECTIVE:To evaluate whether self-reported past migraine response to reproductive life events (menses, pregnancy, menopause) alters the likelihood of worsening of migraine with exogenous hormone use. METHODS:A retrospective study was conducted on 451 female patients at the University Headache Center who had a diagnos...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2000.00027.x

    authors: Mueller L

    更新日期:2000-03-01 00:00:00

  • Cluster headache and the sympathetic nerve.

    abstract:OBJECTIVE:To determine the effect of a sympathetic block at C7 on cluster headache. BACKGROUND:Eleven patients presenting to a pain control unit with cluster headache were included in the study after giving informed consent. METHODS:In all patients, a mixture of 5 mL of 0.5% bupivacaine hydrochloride and 1 cc of meth...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2004.04038.x

    authors: Albertyn J,Barry R,Odendaal CL

    更新日期:2004-02-01 00:00:00

  • Cerebrovascular reactivity in adolescents with migraine and tension-type headache during headache-free interval and attack.

    abstract:BACKGROUND:Migraine is a common cause of headache in adolescents. Assuming that the cerebral vasculature is involved in the pathophysiology of migraine, we compared cerebral vasoreactivity in adolescents both during a migraine attack and a headache-free interval. METHODS:A functional transcranial Doppler test utilizin...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2003.03090.x

    authors: Rosengarten B,Sperner J,Görgen-Pauly U,Kaps M

    更新日期:2003-05-01 00:00:00

  • Neuromodulators for migraine prevention.

    abstract::Migraine is a debilitating condition characterized by a cycle of painful headaches and headache-related symptoms interspersed with periods of worry, distress, and apprehension. The negative impact of migraine on patient functioning, workplace productivity, and other daily activities has been demonstrated through the u...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/j.1526-4610.2007.01040.x

    authors: Kaniecki R

    更新日期:2008-04-01 00:00:00

  • Valsalva-induced cluster: a new subtype of cluster headache.

    abstract::We report the case of a man who suffered from Valsalva-induced cluster headaches. The headaches deviated from classic cluster in that they were solely induced by activity involving the Valsalva maneuver, such as coughing and sneezing, and never occurred spontaneously. The attacks were prevented by treatment with indom...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.2002.02088.x

    authors: Ko J,Rozen TD

    更新日期:2002-04-01 00:00:00

  • Topiramate vs divalproex sodium in the preventive treatment of migraine: a prospective "real-world" study.

    abstract:BACKGROUND AND OBJECTIVES:Certain neuromodulators, most notably topiramate (TPM) and divalproex sodium (DVP), are effective preventive agents for migraine. Published data from head-to-head studies comparing TPM and DVP are not available. The purpose of this study was to compare TPM and DVP for the prophyaxis of migrain...

    journal_title:Headache

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1526-4610.2011.01868.x

    authors: Krymchantowski AV,Jevoux CC

    更新日期:2011-04-01 00:00:00

  • Occipital lobe tumor presenting as migraine with typical aura.

    abstract::We report the case of a 60-year-old woman in whom migraine with typical aura heralded the presence of an occipital lobe tumor. Her headache was characterized by recurrent episodes of visual aura confined to the left visual field followed by right hemicranial throbbing headaches accompanied by nausea, photophobia, and ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1996.3601049.x

    authors: Verma A,Rosenfeld V,Forteza A,Sharma KR

    更新日期:1996-01-01 00:00:00

  • Migraine mimics.

    abstract::The symptoms of migraine are non-specific and can be present in many other primary and secondary headache disorders, which are reviewed. Even experienced headache specialists may be challenged at times when diagnosing what appears to be first or worst, new type, migraine status, and chronic migraine. ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/head.12518

    authors: Evans RW

    更新日期:2015-02-01 00:00:00

  • Outpatient repetitive intravenous dihydroergotamine.

    abstract::The efficacy of the repetitive intravenous dihydroergotamine (DHE) inpatient protocol for refractory headache is well established. We conducted a retrospective and prospective study of long-term headache patients at our clinic to evaluate this regimen in an outpatient setting. Treatment consisted of oral metoclopramid...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.1992.hed3209455.x

    authors: Robbins L,Remmes A

    更新日期:1992-10-01 00:00:00

  • Chronic paroxysmal hemicrania and hemicrania continua: lack of efficacy of sumatriptan.

    abstract::Attacks of chronic paroxysmal hemicrania are prevented by the continuous administration of indomethacin. Sumatriptan, an agonist of 5-HT1-like receptors, has proven effective in the treatment of cluster headache attacks. There are clear clinical similarities between chronic paroxysmal hemicrania and cluster headache. ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1998.3803197.x

    authors: Antonaci F,Pareja JA,Caminero AB,Sjaastad O

    更新日期:1998-03-01 00:00:00

  • Analgesic rebound headache in clinical practice: data from a physician survey.

    abstract:BACKGROUND:Frequent, excessive use of over-the-counter or prescription analgesics may lead to analgesic rebound headache. Little is known about the magnitude of the health problem posed by analgesic rebound headache, its epidemiology, the characteristics of analgesic rebound headache sufferers, or about physicians' app...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1046/j.1526-4610.1996.3601014.x

    authors: Rapoport A,Stang P,Gutterman DL,Cady R,Markley H,Weeks R,Saiers J,Fox AW

    更新日期:1996-01-01 00:00:00

  • Acetaminophen, aspirin, and caffeine versus sumatriptan succinate in the early treatment of migraine: results from the ASSET trial.

    abstract:OBJECTIVE:To address the need for a rigorous, direct comparison of prescription and over-the-counter (OTC) migraine drugs and to expand the database on early treatment of migraine. BACKGROUND:Most people who experience migraine use OTC medications to treat their symptoms, but no head-to-head clinical trials comparing ...

    journal_title:Headache

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1526-4610.2005.05177.x

    authors: Goldstein J,Silberstein SD,Saper JR,Elkind AH,Smith TR,Gallagher RM,Battikha JP,Hoffman H,Baggish J

    更新日期:2005-09-01 00:00:00

  • Distinct pharmacokinetic profile and safety of a fixed-dose tablet of sumatriptan and naproxen sodium for the acute treatment of migraine.

    abstract:OBJECTIVE:To describe the pharmacokinetic and safety profiles of sumatriptan 85 mg formulated with RT Technology (RT) and naproxen sodium 500 mg in a fixed-dose combination tablet (sumatriptan/naproxen sodium) that targets both serotonergic dysmodulation and inflammation in migraine. METHODS:Six open-label, crossover ...

    journal_title:Headache

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1526-4610.2009.01606.x

    authors: Haberer LJ,Walls CM,Lener SE,Taylor DR,McDonald SA

    更新日期:2010-03-01 00:00:00

  • Marketed oral triptans in the acute treatment of migraine: a systematic review on efficacy and tolerability.

    abstract:BACKGROUND:In the current literature, there is neither a reported systematic review comparing the efficacy of triptans at 30 minutes and 1 hour after the migraine treatment, nor data related to efficacy of new marketed triptans. OBJECTIVE:The main objective of this analysis was to compare the efficacy and tolerability...

    journal_title:Headache

    pub_type: 杂志文章,评审

    doi:10.1111/j.1526-4610.2007.00849.x

    authors: Pascual J,Mateos V,Roig C,Sanchez-Del-Rio M,Jiménez D

    更新日期:2007-09-01 00:00:00

  • A 3-month analysis of disability, quality of life, and disease course in patients with migraine.

    abstract:OBJECTIVE:To describe a short-term "real-life" longitudinal evolution of migraine course, quality of life, and disability in a sample of patients attending to a specialty center and to evaluate the association between the changes in patient-reported outcomes, number of reported headaches, their severity, and treatment ...

    journal_title:Headache

    pub_type: 杂志文章

    doi:10.1111/j.1526-4610.2012.02279.x

    authors: Raggi A,Leonardi M,Bussone G,D'Amico D

    更新日期:2013-02-01 00:00:00

  • Nalpha-methylhistamine safety and efficacy in migraine prophylaxis: phase I and phase II studies.

    abstract:OBJECTIVE:To study the therapeutic potential of the subcutaneous administration of Nalpha-methylhistamine in migraine prophylaxis. BACKGROUND:The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. We consequently considered it viable to conduct a clinical pharmacological stu...

    journal_title:Headache

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1526-4610.2003.03074.x

    authors: Millán-Guerrero RO,Pineda-Lucatero AG,Hernández-Benjamín T,Tene CE,Pacheco MF

    更新日期:2003-04-01 00:00:00