Abstract:
:Flunarizine is a non-selective calcium antagonist. It distributes preferentially in the adipose tissue and passes the blood brain barrier. Numerous controlled clinical studies have established that flunarizine is efficacious in migraine prophylaxis, including double-blind studies in which the drug was compared with placebo or other antimigraine drugs. To avoid side effects a special schedule or administration is necessary. Flunarizine has no myogenic effect on smooth muscle cells of the vessles. It is said to be the only calcium antagonist able to protect brain cells against hypoxic damage. In addition, the considerable body of information which shows flunarizine capable of directly influencing the central nervous system, suggests that the drug's anti-migraine action may depend on its ability to influence central phenomena.
journal_name
Headachejournal_title
Headacheauthors
Leone M,Grazzi L,La Mantia L,Bussone Gdoi
10.1111/j.1526-4610.1991.hed3106388.xsubject
Has Abstractpub_date
1991-06-01 00:00:00pages
388-91issue
6eissn
0017-8748issn
1526-4610journal_volume
31pub_type
临床试验,杂志文章,随机对照试验,评审相关文献
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pub_type: 临床试验,杂志文章,多中心研究
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