Abstract:
BACKGROUND:In patients with episodic migraine (EM), diffusion tensor imaging (DTI) revealed microstructural white matter alterations in various brain regions related to pain processing. Some of these changes were correlated with migraine duration and attack frequency, suggesting that migraine is a progressive disease with proceeding structural alterations of the brain. This study aimed to identify possible microstructural white matter alterations in patients with chronic migraine (CM) using DTI. We hypothesized that alterations in DTI are more pronounced in patients with CM compared with EM. METHODS:Individually, age- and sex-matched subjects with CM without aura, EM without aura, and healthy controls (n = 21 per group) underwent conventional head magnetic resonance imaging and DTI imaging in a 3T MRI scanner and were included in analysis. DTI data were analyzed using a tract-based spatial statistics approach. Fractional anisotropy (FA), mean diffusivity, radial diffusivity, and axial diffusivity were compared between subjects with CM and EM, CM and controls, EM and controls, as well as between all subjects with migraine (EM + CM) and controls. RESULTS:In chronic migraineurs (mean age 49 ± 7.5 years), we did not find any statistically significant difference (P < .05, threshold-free cluster enhancement corrected for multiple comparison) in DTI-derived parameters in comparison with episodic migraineurs (FA: P > .245) and healthy controls (FA: P > .099). In contrast to previous DTI studies, we did not find alterations in DTI-derived indices in subjects with EM compared with healthy controls (FA: P > .486). CONCLUSIONS:No microstructural white matter changes could be observed in middle-aged chronic and episodic migraineurs using DTI. CM does not seem to be a risk factor for progressive microstructural changes in DTI.
journal_name
Headachejournal_title
Headacheauthors
Neeb L,Bastian K,Villringer K,Gits HC,Israel H,Reuter U,Fiebach JBdoi
10.1111/head.12496subject
Has Abstractpub_date
2015-02-01 00:00:00pages
241-51issue
2eissn
0017-8748issn
1526-4610journal_volume
55pub_type
杂志文章相关文献
HEADACHE文献大全abstract::We studied 11 patients undergoing a routine lumbar puncture to determine if there were cerebrospinal fluid leaks at the puncture site and whether the maximum volume of leakage correlates with a lumbar puncture headache. Patients completed a headache questionnaire before and after the lumbar puncture. Limited magnetic ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1995.hed3507420.x
更新日期:1995-07-01 00:00:00
abstract::A 25-year-old female patient developed headache and papilledema under sulphasalazine treatment for ulcerative colitis. The patient met the International Headache Society's criteria for idiopathic intracranial hypertension. Sulphasalazine was discontinued and the patient was given azathioprine for ulcerative colitis an...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2007.00992.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to establish whether increased sensitivity to mechanical stimuli is present in neural tissues in chronic tension-type headache (CTTH). BACKGROUND:Muscle hyperalgesia is a common finding in CTTH. No previous studies have investigated the sensitivity of peripheral nerves in patients with CTTH....
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.2008.00856.x
更新日期:2008-04-01 00:00:00
abstract::The aim of the study was to compare adult migraine discordant full siblings in terms of personality and psychosocial environment during childhood. The study, involving 30 sibling pairs and use of various personality instruments (Eysenck Personality Inventory [EPI], Color Word Test [CWT], Visual Aftereffects [VAE], Met...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1997.3703159.x
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:It has been suggested that homocysteine (Hcy) and the 5'-10'-methylenetetrahydrofolate reductase (MTHFR) C677T variant are implicated in the pathogenesis of migraine. Homocysteine has the potential to damage endothelium and accelerate atherosclerosis. Genetic factors such as the MTHFR C677T polymorphism, and...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01484.x
更新日期:2010-01-01 00:00:00
abstract::Consumption of monosodium glutamate has long been considered to precipitate headaches in susceptible patients. In this study the direct effects of glutamate and its metabolite, glutamine, on arterial contractility were examined using rings of rabbit aorta. In a high concentration glutamate caused significant concentra...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1990.hed3009575.x
更新日期:1990-09-01 00:00:00
abstract::Headache is a common disorder in the general population. It is often highly debilitating for the people affected and highly costly to society. Although we know much about primary headaches, little is known about secondary headaches which, however,are a frequent occurrence in the general population. A study conducted o...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2009.01390.x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:It is generally felt that patient education and patient knowledge regarding triptan use for acute migraine management are important for successful and safe treatment. It is unclear how knowledgeable triptan users are regarding their triptan, how much education occurs when triptans are prescribed, and the imp...
journal_title:Headache
pub_type: 杂志文章,多中心研究
doi:10.1111/head.12286
更新日期:2014-04-01 00:00:00
abstract::A self-administered questionnaire covering the diagnostic criteria of the International Headache Society was completed by 1208 undergraduates of the National University of Singapore to determine the prevalence and characteristics of headaches in this population. The relationship between headaches and depressive illnes...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1997.3701026.x
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:The etiology of transient global amnesia (TGA) remains unclear, and flow disturbances in the mesial temporal lobes secondary to venous congestion have been proposed as a potential cause. The occurrence of TGA during a migraine attack is a rare condition. METHODS:This 11-year retrospective study in one French...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12545
更新日期:2015-06-01 00:00:00
abstract::The drug discovery programs that led to the development of the triptans were determined by the membership of the American Headache Society to be the most important breakthrough in headache medicine in the last 50 years. Dr. Humphrey, who spearheaded the drug discovery, recounts the pioneering work that took place and ...
journal_title:Headache
pub_type: 历史文章,杂志文章
doi:10.1111/j.1526-4610.2008.01097.x
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administrati...
journal_title:Headache
pub_type: 杂志文章,随机对照试验
doi:10.1111/head.13165
更新日期:2017-11-01 00:00:00
abstract::Migraine shares a complex and poorly understood relationship with sleep. Patients consistently report poor sleep prior to migraine attacks and during them, identifying poor sleep as a migraine trigger. However, anecdotally, sleep is reported to serve a therapeutic role in terminating headache. Are the associations bet...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.13358
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Migraine is a common neurological disorder, ranked among the world's leading causes of years lived with disability by the World Health Organization. The burden of migraine is highest in women of reproductive age. METHODS:We characterized the prevalence, symptoms, and correlates of migraine and other headach...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12206
更新日期:2014-04-01 00:00:00
abstract::This study examined the pharmacokinetics of 300 mg of tiaprofenic acid, a NSAID belonging to the 2-arylpropionic class, as a single oral dose, in 10 migraine patients during and out of migraine attacks. Plasma concentration of tiaprofenic acid was determined by HPLC analysis. Drug absorption appeared to be the same du...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1990.hed3010672.x
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVE:To describe the statuslike pattern of SUNCT (short-lasting unilateral neuralgiform pain with conjunctival injection and tearing) in two young women. BACKGROUND:SUNCT syndrome is a rare condition characterized by a short-lasting periocular pain associated with marked autonomic symptoms. Twenty-five cases have...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.01151.x
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Variables that are thought to precipitate migraine or tension-type headache episodes in children hitherto have only been studied using retrospective reports. As such, there is little empirical evidence to support the actual predictive association between presumed headache triggers and actual headache occurre...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01586.x
更新日期:2010-05-01 00:00:00
abstract::Evidence has accumulated in recent years indicating structural, physiologic, and biochemical alterations in the brain of patients with chronic migraine (CM). Altered pharmacologic responses to opioids and other analgesics have also been reported. Structural or morphologic changes include reduced cortical gray matter o...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2011.01955.x
更新日期:2011-07-01 00:00:00
abstract::Many investigators have described olfactory dysfunction among migraineurs. Olfactory stimuli can precipitate migraine, and olfactory hallucinations can occur as auras of migraines or as part of the symptom complex. Despite many reports linking olfactory phenomena and migraine, no evaluations of the olfactory abilities...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1992.hed3205233.x
更新日期:1992-05-01 00:00:00
abstract::If you vomit with migraines, get full-blown migraines upon awakening, or want rapid relief without injections, consider a nasal spray. Options include triptans (zolmitriptan [Zomig] or sumatriptan [Imitrex]), DHE (Migranal), or an NSAID (Sprix). ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12045
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To assess the degree of debilitation and the treatment views of individuals with headache presenting to a community pharmacy. BACKGROUND:Migraine and chronic daily headache are common poorly managed illnesses. Pharmacists recommend an over-the-counter "headache product" to customers more than 53 000 times da...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2004.04016.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To describe the outcome of a patient with refractory chronic paroxysmal hemicrania (CPH) to occipital nerve stimulation (ONS). BACKGROUND:CPH is a primary headache disorder exquisitely sensitive to indomethacin. In patients unable to tolerate indomethacin, the therapeutic options are limited. ONS is a promis...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13187
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To determine the effect of a sympathetic block at C7 on cluster headache. BACKGROUND:Eleven patients presenting to a pain control unit with cluster headache were included in the study after giving informed consent. METHODS:In all patients, a mixture of 5 mL of 0.5% bupivacaine hydrochloride and 1 cc of meth...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2004.04038.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between migraine and nonmigrainous headache and asthma, hay fever, and chronic bronchitis in a large cross-sectional population-based study. BACKGROUND:Associations between prevalence of migraine and asthma or allergy have been demonstrated in clinic-based and epidemiologic studi...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00597.x
更新日期:2007-02-01 00:00:00
abstract::Greater occipital nerve (GON) infiltration is widely used for the treatment of primary and secondary headache disorders mainly on the basis of open-label evidence, although recent double-blinded placebo-controlled trials have demonstrated its efficacy in cluster headache. The procedure is generally well tolerated alth...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2012.02270.x
更新日期:2012-11-01 00:00:00
abstract::Seven SUNCT patients (six men, one woman) took part in this study. In four patients, respiratory variables were compared during and outside attacks. In five patients, peripheral chemosensitivity was tested and compared with a control group matched with respect to age, sex, and smoking habits. The results indicate that...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1995.hed3506344.x
更新日期:1995-06-01 00:00:00
abstract::A questionnaire study on headaches, using a door-to-door survey, was carried out in a representative sample of the general Greek population, including 1737 men and 1764 women, from 15 to 75 years of age. The parameters evaluated included age, sex, education, socioeconomic status, region of domicile, frequency of heada...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1996.3603168.x
更新日期:1996-03-01 00:00:00
abstract::This paper describes the development and validation of a migraine-specific quality-of-life instrument that is capable of measuring health-related quality-of-life impairments attributed to migraine. Item selection, item reduction, and pretesting and finalization of items during the instrument development phase resulted...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1998.3804295.x
更新日期:1998-04-01 00:00:00
abstract::Seven hundred three subjects completed a randomized, double-blind, parallel-group, single-center study comparing the single-dose efficacy of ketoprofen 12.5 mg, ketoprofen 25 mg, acetaminophen 1000 mg, and placebo in the treatment of tension headache. For the primary efficacy variable, 4-hour sum of pain relief intens...
journal_title:Headache
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1526-4610.1998.3808579.x
更新日期:1998-09-01 00:00:00
abstract::More than 60 years ago Aristides Leão coined the term spreading depression (SD) to describe a transient "depression" of electrocorticographic activity that lasts up to several minutes and slowly "spreads" in all directions in cortex by way of gray matter contiguity.(1) Today we know that SD is an intrinsic electrophys...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2010.01647.x
更新日期:2010-04-01 00:00:00