Abstract:
:Cardiac function is impaired in adults or children with hypothyroidism and it can be reversed by levothyroxine (L-T(4)) substitution therapy. However, only a few studies are available on left and right ventricular function in neonates with congenital hypothyroidism (CH), most of which were performed with standard echocardiography. The aim of this study was to investigate the effects of L-T(4) substitution therapy on left and right ventricular function in neonates with CH, measured with tissue Doppler echocardiography (TDE) and conventional echocardiography. Fifty neonates (27 females and 23 males) with CH and 35 normal neonates (19 females and 16 males) underwent conventional echocardiography and TDE. On TDE, peak mitral and tricuspid annular systolic (Sa) velocity, peak early (Ea) and late (Aa) mitral and tricuspid annular diastolic velocity were measured, and the Ea/Aa ratio was calculated. All the biochemical tests and echocardiographic evaluations were reevaluated after 1 month of replacement therapy. In CH neonates, TDE showed that CH neonates had significantly lower Sa, Ea, and Ea/Aa of both left and right ventricles (P<0.001, respectively). However, Aa of left and right ventricles did not differ significantly. After 1 month of substitutive therapy, CH neonates showed a significant increase of Sa and Ea and a subsequent increase of the Ea/Aa ratio (P<0.001, respectively). Our findings suggest that neonates with CH suffer from right ventricular subclinical systolic and diastolic dysfunction in addition to left ventricular dysfunction. Early L-T(4) substitution therapy is able to reverse the impairment of cardiac function.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Mao S,Wang Y,Jiang G,Zhao Zdoi
10.1007/s00431-007-0417-zsubject
Has Abstractpub_date
2007-12-01 00:00:00pages
1261-5issue
12eissn
0340-6199issn
1432-1076journal_volume
166pub_type
杂志文章abstract::Perinatal transmission remains the main cause of HIV infection in the pediatric population. Treatment of HIV-infected children has become less of a problem in resource-rich countries with a remarkable decrease of perinatal infections, resulting in an effective prevention of mother-to-child transmission and antiretrovi...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-008-0914-8
更新日期:2009-04-01 00:00:00
abstract::Acute urinary tract infection (UTI) is the most common bacterial infection in childhood. Although hyponatremia was described in ~ 2/3 of these children, its clinical significance is still unclear. Herein, we evaluated the prevalence and clinical implications of hyponatremia in children hospitalized with a UTI. Medical...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03808-z
更新日期:2020-09-19 00:00:00
abstract:UNLABELLED:We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing nu...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02002905
更新日期:1996-09-01 00:00:00
abstract::Continuous negative extrathoracic pressure (CNEP) has been recently reintroduced as therapy for respiratory failure. To determine its effects on cardiac output a pilot study was performed in ten patients aged 2 months-3 years (median 4 months). All had chronic respiratory failure (seven with bronchopulmonary dysplasia...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01954088
更新日期:1993-07-01 00:00:00
abstract::Vascularization of the arms has been studied by impedance plethysmography (rheography) in eight children with Poland syndrome, a common malformation characterized by unilateral hand anomaly and ipsilateral aplasia of the inferior head of the pectoralis major muscle. A marked decrease of the velocity of the systolic in...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00496922
更新日期:1978-05-22 00:00:00
abstract:UNLABELLED:Isolated partial 3-methylcrotonyl-CoA carboxylase (MCC) deficiency has been described to be the cause for a distinct relatively mild clinical picture in a single patient. We describe another patient with isolated partial MCC deficiency who suffered from failure to thrive, muscular hypotonia and progressive r...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050800
更新日期:1998-03-01 00:00:00
abstract:INTRODUCTION:Randomly estimated fasting hyperglycaemia in an asymptomatic individual may represent the first sign of pancreatic beta-cell dysfunction. OBJECTIVE:We aimed at specifying the genetic aetiology of asymptomatic hyperglycaemia in a cohort of children and adolescents. SUBJECTS AND METHODS:We analysed the aet...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0106-3
更新日期:2006-07-01 00:00:00
abstract::One hundred and twenty two cases of severe hyaline membrane disease are reported. 68 of them survived (57%). Adverse clinical, radiological and laboratory factors, and their effects on the early mortality rate, are analysed with particular reference to the referring centers, delay in admission, transport and the criti...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442059
更新日期:1978-03-13 00:00:00
abstract:UNLABELLED:Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disease, caused by specific primary structural and/or functional abnormalities of the motile cilia, in contrast with the transitory abnormalities seen in secondary ciliary dyskinesia. Disease-causing mutations in at least 16 genes have already be...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-012-1785-6
更新日期:2013-02-01 00:00:00
abstract::Arterial hypertension in childhood is less frequent as compared to adulthood but is more likely to be secondary to an underlying disorder. After ruling out more obvious causes, some patients still present with strongly suspected secondary hypertension of yet unknown etiology. A number of these children have hypertensi...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-011-1440-7
更新日期:2012-10-01 00:00:00
abstract::The aim of this study was to evaluate the feasibility of clinical application of infrared thermography (IRT) in the pediatric population and to identify pathological states that can be diagnosed as well as followed up using this non-invasive technique. In real time computer-assisted IRT, 483 examinations were performe...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0583-z
更新日期:2008-07-01 00:00:00
abstract::A male infant with transient citrullinemia is described. Initially, he was found to have hypertyrosinemia and hypermethioninemia upon routine neonatal screening for inborn errors of metabolism performed at 4 days of age and was revealed to have citrullinemia upon detailed examination of plasma amino acids. At 30 days ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445674
更新日期:1983-10-01 00:00:00
abstract::We have evaluated 46 patients with Turner syndrome by clinical examination, M-mode and two-dimensional echocardiography, dynamic exercise testing and 24 h Holter monitoring. Twelve patients (26.1%) had mitral valve prolapse and 7 patients (15.2%) had isolated non stenotic bicuspid aortic valve. Aortic root dilation wa...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441551
更新日期:1989-04-01 00:00:00
abstract::Congenital high airway obstruction syndrome (CHAOS) is a rare prenatal diagnosis consisting of a typical fetal triad of large hyperechogenic lungs, flattened or inverted diaphragms and ascites. Most cases are sporadic with unknown incidence. Before attempts of fetoscopic fetal salvage or ex utero intrapartum treatment...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0134-z
更新日期:2006-10-01 00:00:00
abstract:UNLABELLED:Intravenous immunoglobulin (IVIG) is currently the standard treatment for Kawasaki disease (KD). Although IVIG therapy is generally well tolerated, several minor adverse reactions have been reported. We report a patient with KD treated with IVIG, who developed a cutaneous reaction in the convalescent phase (...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/s00431-012-1898-y
更新日期:2013-03-01 00:00:00
abstract::We present an infant with Dubowitz syndrome diagnosed at birth and followed for 2 years. Presence of the syndrome was suspected at birth on the basis of the anthropometric data and peculiar facial appearance. However, during the follow-up period some changes in the appearance have taken place. It is suggested that the...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441881
更新日期:1986-04-01 00:00:00
abstract:UNLABELLED:The objective of this analysis was to determine the relationship between wheezing at different age groups in children and the prevalence of bronchial hyperreactivity at the age of 10. A population-based cross-sectional study was conducted in Leipzig and the region around Halle in Germany. Of 3105 10-year-old...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02190692
更新日期:1994-09-01 00:00:00
abstract::In a German pediatric oncology unit, the attending physicians diagnosed 27 cases of Clostridium difficile-associated disease (CDI) from January 01, 2010 to October 31, 2013. This refers to a CDI incidence density of 2.0/1000 inpatient days. According to the hospital hygiene standard, symptomatic patients with CDI were...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-017-3070-1
更新日期:2018-03-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441415
更新日期:1988-12-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章
doi:10.1007/s004310050550
更新日期:1997-01-01 00:00:00
abstract::Retraction Note to: Eur J Pediatr (1994) 153:668-671 DOI 10.1007/BF02190689. This article, "Adenosine triphosphate treatment for supraventricular tachycardia in infants", published in the European Journal of Pediatrics (1994) 153/9: 668-671, Springer-Verlag 1994, has been retracted at the request of the Publisher as i...
journal_title:European journal of pediatrics
pub_type: 撤回出版物
doi:10.1007/s00431-015-2640-3
更新日期:2015-11-01 00:00:00
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journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0572-2
更新日期:2008-07-01 00:00:00
abstract::We describe an outbreak of echovirus type 18 infection involving 20 neonatal intensive care unit (NICU) patients and the results of virological investigations are presented. RT-PCR demonstrated a widespread transmission of the virus in NICU patients during the outbreak. Separation care and additional infection control...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-007-0516-x
更新日期:2008-05-01 00:00:00
abstract::Protein C deficiency can lead to cerebrovascular occlusive disease. We describe a patient in whom heterozygous protein C deficiency (type 1) is suspected on the grounds of reduced protein C activity and who suffered from multiple thrombo-embolic events involving the brain and peripheral organs. The patient developed h...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01959356
更新日期:1992-06-01 00:00:00
abstract:UNLABELLED:Aim of our study was to evaluate Doppler renal blood flow velocity in asphyxiated neonates and to correlate renal function to Doppler findings. Doppler renal blood flow velocity was evaluated in 23 severely asphyxiated neonates born at a gestational age > 32 weeks and compared to our standard Doppler data ob...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310050905
更新日期:1998-08-01 00:00:00
abstract::In recent years, a more stable AVP surrogate, called copeptin, has been used as an adjuvant diagnostic tool for dysnatremia in adults and appears to be promising even in the pediatric age. The aim of this study is to present the distribution of plasma copeptin in a large pediatric cohort and to observe the influence o...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-020-03777-3
更新日期:2021-01-01 00:00:00
abstract::Adolescents have specific healthcare needs distinct from adults or younger children secondary to anatomical, physiological and socio-behavioural differences. Healthcare providers have been slow to address this, leading the UK Department of Health (2011) to publish 'You're Welcome' quality criteria for services for you...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-016-2815-6
更新日期:2017-02-01 00:00:00
abstract:UNLABELLED:To examine the value of surfactant protein D and KL-6 as markers for the diagnosis and the severity of interstitial pneumonia caused by measles infection, surfactant protein D, KL-6 and lactic acid dehydrogenase were measured serially in three patients with measles complicated by interstitial pneumonia as co...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s004310100763
更新日期:2001-07-01 00:00:00
abstract::A 10-year-old boy presented with priapism of 10 h duration which after unsuccessful conservative measures, was relieved by a saphenocorporeal shunt. A 4-year history of intermittent vague aching of fingers and toes accompanied by low-grade fever was reported. Fabry disease was confirmed by the lack alpha-galactosidase...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01959404
更新日期:1990-04-01 00:00:00
abstract::The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their ...
journal_title:European journal of pediatrics
pub_type: 杂志文章,评审
doi:10.1007/BF01995850
更新日期:1989-11-01 00:00:00