Abstract：
:Acute urinary tract infection (UTI) is the most common bacterial infection in childhood. Although hyponatremia was described in ~ 2/3 of these children, its clinical significance is still unclear. Herein, we evaluated the prevalence and clinical implications of hyponatremia in children hospitalized with a UTI. Medical records of previously healthy children hospitalized between January 2011 and December 2016 with UTI were retrospectively reviewed. Patients (median age 5.5 months) were divided into two groups according to their sodium levels: normonatremia (Na ≥ 135 mEq/L) and hyponatremia (Na < 135 mEq/L). Hyponatremia diagnosed on admission was found in 114/219 children (49%). Hyponatremic patients experienced a more severe disease manifested by a longer hospital stay (3.8 vs 3.4 days, p = 0.003), a higher prevalence of abnormal findings on renal ultrasound (10 vs 2, p = 0.01), higher C-reactive protein (CRP) levels (8.6 vs 3.4 mg/dl, p = <0.001), and a negative correlation between sodium levels and CRP (r = - 0.38, p < 0.001).Conclusion:Hyponatremia occurs frequently in children hospitalized with UTI and is associated with elevated inflammatory markers and a more severe disease course. What is Known: • Hyponatremia, one of the most common electrolyte abnormalities, occurs in approximately 1/3 of hospitalized children and in 2/3 of children with pyelonephritis. • In certain cases of various medical conditions, hyponatremia has been shown to correlate with disease severity. What is New: • Hyponatremia in hospitalized children with UTI correlates with elevated inflammatory markers and a more severe disease course.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Pappo A,Gavish R,Goldberg O,Bilavsky E,Bar-Sever Z,Krause Idoi
10.1007/s00431-020-03808-zsubject
Has Abstractpub_date
2020-09-19 00:00:00eissn
0340-6199issn
1432-1076pii
10.1007/s00431-020-03808-zpub_type
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journal_title：European journal of pediatrics
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abstract：:To find out whether cytomegalovirus (CMV) infection during the first months of life influences child development, developmental assessment at the age of 2 years was performed on 116 Finnish children chosen at random in a maternity hospital and followed from birth for the occurrence of CMV infection. Two of the childre...
journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-006-0134-z
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02002713
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00442334
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00439238
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
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journal_title：European journal of pediatrics
pub_type： 杂志文章
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journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01957224
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abstract：UNLABELLED:The objective of this open study was to monitor the long-term effectiveness of the Lederle-Takeda diphtheria and tetanus toxoids and acellular pertussis antigen(s) (DTaP) vaccine and the Wyeth-Lederle diphtheria and tetanus toxoids and pertussis whole cell (DTP) vaccine in children who had received four dose...
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pub_type： 杂志文章
doi：10.1007/s00431-001-0893-5
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