Abstract:
:Natural killer cell (NK) is known as a major immune system in body through mediating cell death via several possible pathways, and one of three subpopulations of lymphocytes functioning as scavenger of tumor, virus infected cells etc. Our present results found that the SOD-contained silkworm larvae powder caused an enhancement of the effect on NK cell cytotoxicity, which implied this material modulated the immune system in mice in vivo. The NK cell activities of S180 tumor modeled mice treated with silkworm powder including SOD were enhanced significantly ranging from 30% to 48%, respectively, compare to a distilled water feeding control and silkworm powder without SOD. Meanwhile, the ConA-stimulated splenocyte proliferation of all three treated groups was higher than that of the control both in T cells or B cells. The average tumor weight of S180 modeled mice treated with doses of SOD-contained silkworm powder was lighter than that of water control showing the tumor inhibition rates (IR) reached to 22.51% to 37%, respectively. In conclusion, these findings demonstrate that administration of silkworm larvae powder containing SOD results in activation of NK cells and immune T-cell and B-cell, suggesting the silkworm larvae powder containing SOD play a positive role in tumor inhibition.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Yue WF,Yao ML,Liu JM,Li GL,Li XH,Wu XF,Deng W,Sun HX,Zhou JY,Zhang CX,Miao YGdoi
10.1007/s11033-007-9165-4subject
Has Abstractpub_date
2009-01-01 00:00:00pages
187-92issue
1eissn
0301-4851issn
1573-4978journal_volume
36pub_type
杂志文章abstract::Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3737-x
更新日期:2015-01-01 00:00:00
abstract::The melanocortin-4 receptor (MC4R) plays an important role in weight and energy homeostasis and it is associated with lower risk to develop obesity and lower body mass index. The contribution of MC4R mutation to obesity in Vojvodina (Northern Province of Serbia), known as a region with the largest number of overweight...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9500-z
更新日期:2010-01-01 00:00:00
abstract::MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0252-6
更新日期:2011-03-01 00:00:00
abstract::Polyomavirus JC (JCPyV) is a ubiquitous human neurotropic virus that can cause progressive multifocal leukoencephalopathy (PML), sometimes as a consequence of drug treatment for disabling diseases, including Multiple Sclerosis. JCPyV expresses microRNAs (miRNAs), and in particular miR-J1-5p, but at now we have limited...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05862-0
更新日期:2020-11-01 00:00:00
abstract::The complete mitochondrial genomes of five tiger samples from three subspecies (P. t. sumatrae, P. t. altica, and P. t. tigris) were successfully obtained by using 26 specifically designed Panthera-specific primer sets. The genome organization and gene arrangement of the five tiger samples were similar to each other; ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1384-z
更新日期:2012-05-01 00:00:00
abstract::Rheumatic heart disease (RHD) or acute rheumatic fever (ARF) develops as a consequence of an exaggerated immune response to Group A beta haemolytic streptococci causing pharyngitis. The molecular mimicry appears between human cardiac myosin and M protein of group A streptococcal membranes. The polymorphism of the prot...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0692-7
更新日期:2011-11-01 00:00:00
abstract::Osteocytic potentiality of human CD34+ stem cells explored in the present study by generating in vitro agarose gel 3D model to understand the bone ossification process. The G-CSF and IL-3 mobilized human CD34+ stem cells isolated apheretically from donor peripheral blood and purity of the cells was assessed by FACS an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4053-4
更新日期:2016-11-01 00:00:00
abstract::DNA repair capacity (DRC) can be altered based on sequence variations in DNA repair genes, which may result in cancer susceptibility. The current study was to evaluate the association between genetic polymorphisms, including associated haplotypes of xeroderma pigmentosum complementary group D (XPD), and individual sus...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0258-0
更新日期:2011-03-01 00:00:00
abstract::The glutathione S-transferase (GST) family of enzymes is known to play a pivotal role in phase II of biotransformation of xenobiotics, environmental carcinogens and pharmacological drugs. The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstru...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0287-8
更新日期:2011-03-01 00:00:00
abstract::Local domestic chicken populations are of paramount importance as a source of protein in developing countries. Bangladesh possesses a large number of native chicken populations which display a broad range of phenotypes well adapted to the extreme wet and hot environments of this region. This and the fact that wild jun...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2522-6
更新日期:2013-06-01 00:00:00
abstract::Fluorescent proteins related to and derived from green fluorescent protein (GFP) are widely used as tools for investigating a wide range of biological processes. In particular, GFP and its relatives have been used extensively as qualitative reporters of gene expression in many different organisms, but relatively few s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9285-5
更新日期:2009-05-01 00:00:00
abstract::Late blight caused by Phytophthora infestans is the most important disease of potato. Many efforts have been made to understand molecular mechanism of the durable resistance to address the challenge raised by rapid evolution of the pathogen. A pathogenesis related protein (PR) gene StPRp27 was previously isolated from...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0937-5
更新日期:2012-02-01 00:00:00
abstract::Staudtia kamerunensis (Myristicaceae) or 'Niové' is an evergreen tree widespread in Central African moist forests. The bark and seeds are used in traditional medicine, yet the tree is mainly harvested for its high quality, multi-purpose timber. To facilitate sustainable harvesting and conservation of the species, we a...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4239-z
更新日期:2018-10-01 00:00:00
abstract::We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) va...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0975-z
更新日期:2012-03-01 00:00:00
abstract::To investigate whether Annexin 1 can protect a retinal ganglion cells line (RGC-5) from apoptosis as induced by serum deprivation. Annexin 1 location in RGC-5 cells was determined using an indirect immunofluorescent assay. Expression of Annexin 1 in RGC-5 cultures deprived of serum for 0, 2 days was semi-quantified by...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-1358-1
更新日期:2012-05-01 00:00:00
abstract::BAP31 is a ubiquitously expressed integral membrane protein of the endoplasmic reticulum. BAP31 is involved in various biological and molecular processes, including protein transport, viral processing, apoptosis signaling, MHC 1 antigen processing and presentation, mitochondria and ER calcium regulation, and proteasom...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-020-06123-w
更新日期:2021-01-13 00:00:00
abstract::Transcriptional factors are the major regulators of plant signaling pathways in response to environmental stresses i.e., drought, salinity and cold. Hereby, the GhMYB108-like was characterized to determine whether it regulate these stresses. The GhMYB108-like cDNA consisted of 1107 base pairs (bp) with 807 open readin...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05244-6
更新日期:2020-03-01 00:00:00
abstract::A number of regions designated as RD1-RD16 (region of difference) and encompassing 129 open reading frames have been identified between Mycobacterium tuberculosis and Mycobacterium bovis on the one hand and Bacillus Calmette-Guérin on the other. Identification of T cell epitopes from this set of proteins may serve to ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9613-4
更新日期:2010-04-01 00:00:00
abstract::Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1023/a:1006826725056
更新日期:1997-03-01 00:00:00
abstract::The interaction between ovalbumin (OVA) and three purine alkaloids (caffeine, theophylline and diprophylline) was investigated by the aid of intrinsic and synchronous fluorescence, ultraviolet-vis absorbance, resonance light-scattering spectra and three-dimensional fluorescence spectra techniques. Results showed that ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2418-x
更新日期:2013-04-01 00:00:00
abstract::The Fas gene polymorphisms -670A/G (rs1800682) and -1377G/A (rs2234767) have been shown to be associated with systemic lupus erythematosus (SLE), but findings are not consistent. To clarify this point, a meta-analysis was performed. We searched PubMed, CNKI, CBM and Wanfang database. Meta-odds ratios (ORs) and 95 % co...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-012-2075-0
更新日期:2013-01-01 00:00:00
abstract::Interleukin-13 (IL-13) is a TH2 cytokine with direct and indirect immunoregulatory functions on cancer cells. The cytokine has been reported to have some polymorphic variations at the gene level associated with some immune related diseases including asthma and allergy. In the present study, association of three IL13 g...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-008-9400-7
更新日期:2009-09-01 00:00:00
abstract::The aim of the present study was construction of mammary gland specific expression vector for high level of human insulin (hINS) expression in transgenic buffalo for therapeutic use. We have constructed mammary gland specific vector containing human insulin gene and there expression efficiency was checked into in vitr...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3464-3
更新日期:2014-09-01 00:00:00
abstract::Hepatitis B virus (HBV) as the main prevalent infectious agent, play important roles in inducing severe liver diseases. Previous studies demonstrated that during prolonged forms of hepatitis B infection including chronic, asymptomatic and occult forms, patients are unable to eradicate HBV from hepatocytes completely. ...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-014-3190-x
更新日期:2014-05-01 00:00:00
abstract::As-NUPR1, a stress-related protein, plays an important role in post-diapause during embryonic development in the brine shrimp Artemia sinica. In the present study, successful expression of As-NUPR1 from the cDNA sequence isolated from A. sinica was demonstrated using a prokaryotic expression system. The recombinant pr...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3208-4
更新日期:2014-05-01 00:00:00
abstract::Curcumin is a polyphenolic bioactive compound found in the spice turmeric endowed with diverse pharmacological and biological activities. In this study, fluorescence spectroscopy in combination with UV-Vis absorbance spectroscopy was employed to investigate the high affinity binding of curcumin to herring sperm DNA (h...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2530-6
更新日期:2013-07-01 00:00:00
abstract::Accurate normalization of gene expression with qRT-PCR depends on the use of appropriate reference genes (RGs) for the species under a given set of experimental conditions. Multiple RGs for gene expression analysis of soybean exposed to heavy metal stress treatment have not been reported in the literature. In this stu...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0897-9
更新日期:2012-02-01 00:00:00
abstract::Molecular DNA markers are used for detection of polymorphisms in individuals. As they are independent of developmental stage of the plant and environmental influences, they can be useful tools in taxonomy. The alleles of simple sequence repeat (SSR) markers (or microsatellites) are traditionally used to identify taxon...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-015-3927-1
更新日期:2015-11-01 00:00:00
abstract::The mechanism by which external Bax releases cytochrome c is still controversial and may also depend on the type of mitochondria and the actual localisation of cytochrome c. Outer membrane porin acquires high binding affinity for hexokinase by interacting with the adenine nucleotide translocator (ANT) in the contact s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/a:1020383108620
更新日期:2002-01-01 00:00:00
abstract::The epidermal growth factor receptor (EGFR) is an important receptor tyrosine kinase member in animals, which plays versatile functions in development, growth, tissue regeneration etc. Current knowledge on EGFR is poor in bivalve mollusks. In this study, we cloned and analyzed an EGFR gene from the Pacific oyster Cras...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3130-9
更新日期:2014-05-01 00:00:00