当前位置： SCI文献检索 > NUCLEIC ACIDS RESEARCH期刊下所有文献 > LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins.

LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins.

Abstract：

:Conserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix-loop-helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Husbands A,Bell EM,Shuai B,Smith HM,Springer PS

doi

10.1093/nar/gkm775

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

6663-71

issue

19

eissn

0305-1048

issn

1362-4962

pii

gkm775

journal_volume

35

pub_type

杂志文章

相关文献

NUCLEIC ACIDS RESEARCH文献大全
  • The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor.

    abstract：:The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. Microprocessor consists of DROSHA (an RNase III enzyme), and DGCR8. DROSHA contains two RNase III domains, RIIIDa and RIIIDb, which simultaneously cleave the 3p- and 5p-strands of pri-miRNAs, respect...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa018

    authors： Nguyen TL,Nguyen TD,Bao S,Li S,Nguyen TA

    更新日期：2020-03-18 00:00:00

  • Long W tracts are over-represented in the Escherichia coli and Haemophilus influenzae genomes.

    abstract：:The occurrence of DNA tracts of the three binary base combinations: R.Y, K.M and W;S has been mapped in the complete genomes of Haemophilus influenzae and Escherichia coli. A highly significant over-representation of W tracts is observed in both bacteria. The excess of W tracts is particularly striking in the 10% inte...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/27.22.4491

    authors： Shomer B,Yagil G

    更新日期：1999-11-15 00:00:00

  • Orphon spliced-leader sequences form part of a repetitive element in Angiostrongylus cantonensis.

    abstract：:In nematodes, the 22 nucleotide (nt) spliced leader (SL) is normally encoded by a multi-copy, tandemly reiterated SL gene and is trans-spliced from SL-RNA onto the 5' end of a subset of mRNAs. We have found that the SL is also encoded at multiple (> 100) orphon genomic sites in the parasitic nematode Angiostrongylus c...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/23.6.1030

    authors： Joshua GW,Perler FB,Wang CC

    更新日期：1995-03-25 00:00:00

  • Cleavage of a 23S rRNA pseudoknot by phenanthroline-Cu(II).

    abstract：:Studying the intricate folding of rRNA within the ribosome remains a complex problem. Phenanthroline-Cu(II) complexes cleave phosphodiester bonds in rRNA in specific regions, apparently especially where the rRNA structure is constrained in some fashion. We have introduced phenanthroline-copper complexes into 50S Esche...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/27.8.1906

    authors： Muth GW,Thompson CM,Hill WE

    更新日期：1999-04-15 00:00:00

  • ETCM: an encyclopaedia of traditional Chinese medicine.

    abstract：:Traditional Chinese medicine (TCM) is not only an effective solution for primary health care, but also a great resource for drug innovation and discovery. To meet the increasing needs for TCM-related data resources, we developed ETCM, an Encyclopedia of Traditional Chinese Medicine. ETCM includes comprehensive and sta...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gky987

    authors： Xu HY,Zhang YQ,Liu ZM,Chen T,Lv CY,Tang SH,Zhang XB,Zhang W,Li ZY,Zhou RR,Yang HJ,Wang XJ,Huang LQ

    更新日期：2019-01-08 00:00:00

  • Mammalian polyadenylation sites: implications for differential display.

    abstract：:Differential display relies on a series of anchored primers to divide the total mRNA population into subsets of roughly equal size. However, this will only occur if the dinucleotide targeted by the anchor region of the anchored primers has a random frequency distribution [i.e. each of the 12 possible dinucleotides pre...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/27.5.1386

    authors： Frost MR,Guggenheim JA

    更新日期：1999-03-01 00:00:00

  • Detection of base analogs incorporated during DNA replication by nanopore sequencing.

    abstract：:DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no single method can identify the location, direction and speed of replication forks with high resolution. Mammalian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C bases during DNA synthe...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkaa517

    authors： Georgieva D,Liu Q,Wang K,Egli D

    更新日期：2020-09-04 00:00:00

  • Nucleotide sequence analysis of the linked left and right hand terminal regions of adenovirus type 5 DNA present in the transformed rat cell line 5RK20.

    abstract：:A peculiar phenomenon is observed in several adenovirus type 2 or 5 (Ad2 or Ad5) transformed cell lines: the right hand and left hand terminal regions of the viral genome present in the viral DNA insertions of these cell lines are found to be linked together. A large part of the viral DNA insertion present in the Ad5 ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/10.7.2189

    authors： Visser L,Reemst AC,van Mansfeld AD,Rozijn TH

    更新日期：1982-04-10 00:00:00

  • LigParGen web server: an automatic OPLS-AA parameter generator for organic ligands.

    abstract：:The accurate calculation of protein/nucleic acid-ligand interactions or condensed phase properties by force field-based methods require a precise description of the energetics of intermolecular interactions. Despite the progress made in force fields, small molecule parameterization remains an open problem due to the m...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkx312

    authors： Dodda LS,Cabeza de Vaca I,Tirado-Rives J,Jorgensen WL

    更新日期：2017-07-03 00:00:00

  • Direct and site-specific quantification of RNA 2'-O-methylation by PCR with an engineered DNA polymerase.

    abstract：:Methylation of the 2'-hydroxyl-group of ribonucleotides is found in all major classes of RNA in eukaryotes and is one of the most abundant posttranscriptional modifications of stable RNAs. In spite of intense studies, the multiple functions of RNA 2'-O-methylation are still not understood. One major obstacle in the fi...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkw200

    authors： Aschenbrenner J,Marx A

    更新日期：2016-05-05 00:00:00

  • Reactivity of antibodies to guanosine modified by the carcinogen N-acetoxy-N-2-acetylaminofluorene.

    abstract：:N-(guanosin-8-yl) acetylaminofluorene (Guo-AAF) was prepared by the reaction of N-acetoxy-N-2-acetylaminofluorene (AAAF) and guanosine. Antibodies to Guo-AAF were elicited in rabbits by immunization with bovine serum albumin-Guo-AAF conjugate. The antibodies were purified by affinity chromatography on a Sepharose-Guo-...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/6.2.733

    authors： Guigues M,Leng M

    更新日期：1979-02-01 00:00:00

  • Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants.

    abstract：:The cDNA encoding the human RNA lariat debranching enzyme (hDBR1) was identified and cloned by searching the Expressed Sequence Tag (EST) database and screening a HeLa cDNA library, based on predicted amino acid sequence homologies with the Saccharomyces cerevisiae, Schizosaccharomyces pombe and Caenorhabditis elegans...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/28.18.3666

    authors： Kim JW,Kim HC,Kim GM,Yang JM,Boeke JD,Nam K

    更新日期：2000-09-15 00:00:00

  • Site-specific creation of uridine from cytidine in apolipoprotein B mRNA editing.

    abstract：:Human apolipoprotein (apo) B mRNA is edited in a tissue specific reaction, to convert glutamine codon 2153 (CAA) to a stop translation codon. The RNA editing product templates and hybridises as uridine, but the chemical nature of this reaction and the physical identity of the product are unknown. After editing in vitr...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/19.6.1197

    authors： Hodges PE,Navaratnam N,Greeve JC,Scott J

    更新日期：1991-03-25 00:00:00

  • Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis.

    abstract：:Bleomycin B(2)(BLM) in the presence of iron [Fe(II)] and O(2)catalyzes single-stranded (ss) and double-stranded (ds) cleavage of DNA. Electrospray ionization ion trap mass spectrometry was used to monitor these cleavage processes. Two duplex oligonucleotides containing an ethylene oxide tether between both strands wer...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/28.9.1978

    authors： Harsch A,Marzilli LA,Bunt RC,Stubbe J,Vouros P

    更新日期：2000-05-01 00:00:00

  • EK3D: an E. coli K antigen 3-dimensional structure database.

    abstract：:A very high rate of multidrug resistance (MDR) seen among Gram-negative bacteria such as Escherichia, Klebsiella, Salmonella, Shigella, etc. is a major threat to public health and safety. One of the major virulent determinants of Gram-negative bacteria is capsular polysaccharide or K antigen located on the bacterial o...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkv1313

    authors： Kunduru BR,Nair SA,Rathinavelan T

    更新日期：2016-01-04 00:00:00

  • Crystallographic characterization of CCG repeats.

    abstract：:CCG repeats are highly over-represented in exons of the human genome. Usually they are located in the 5' UTR but are also abundant in translated sequences. The CCG repeats are associated with three tri-nucleotide repeat disorders: Huntington's disease, myotonic dystrophy type 1 and chromosome X-linked mental retardati...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gks557

    authors： Kiliszek A,Kierzek R,Krzyzosiak WJ,Rypniewski W

    更新日期：2012-09-01 00:00:00

  • Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signal.

    abstract：:Hepatitis B virus (HBV) replication is initiated by HBV RT binding to the highly conserved encapsidation signal, epsilon, at the 5' end of the RNA pregenome. Epsilon contains an apical stem-loop, whose residues are either totally conserved or show rare non-disruptive mutations. Here we present the structure of the api...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkl582

    authors： Flodell S,Petersen M,Girard F,Zdunek J,Kidd-Ljunggren K,Schleucher J,Wijmenga S

    更新日期：2006-01-01 00:00:00

  • Plateau distributions of DNA fragment lengths produced by extended light exposure of extranuclear photosensitizers in human cells.

    abstract：:We have exploited properties of photosensitizers to study an aspect of the packing of chromatin in the cell nucleus. The fluorescent photosensitizers mesotetra(3-hydroxyphenyl) porphyrin and Photofrin II were both localized in the nuclear membrane and other membrane structures, but could not be found inside the nuclei...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/20.24.6687

    authors： Kvam E,Stokke T,Moan J,Steen HB

    更新日期：1992-12-25 00:00:00

  • An RNasin-resistant ribonuclease selective for interleukin 2 mRNA.

    abstract：:Interleukin 2 (IL2) mRNA has a short half-life in the cytoplasm of T lymphocytes, relative to most mRNA. We have discovered a candidate ribonuclease to account for the rapid turnover of IL2 mRNA in the cytosol of the human T lymphocyte cell line Jurkat. In partially purified form, this RNase is about 7 times as active...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/21.1.155

    authors： Hua J,Garner R,Paetkau V

    更新日期：1993-01-11 00:00:00

  • Genomic analysis of codon, sequence and structural conservation with selective biochemical-structure mapping reveals highly conserved and dynamic structures in rotavirus RNAs with potential cis-acting functions.

    abstract：:Rotaviruses are a major cause of acute, often fatal, gastroenteritis in infants and young children world-wide. Virions contain an 11 segment double-stranded RNA genome. Little is known about the cis-acting sequences and structural elements of the viral RNAs. Using a database of 1621 full-length sequences of mammalian ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkq663

    authors： Li W,Manktelow E,von Kirchbach JC,Gog JR,Desselberger U,Lever AM

    更新日期：2010-11-01 00:00:00

  • Alterations in tRNA isoaccepting species during erythroid differentiation of the Friend leukemia cell.

    abstract：:The chromatographic profiles of isoaccepting tRNAs were analyzed at five time points during the 96 hr, dimethylsulfoxide induced, erythroid-like differentiation of Friend leukemia cells. Sixty-four isoaccepting species of tRNA for 16 amino acids were resolved by RPC-5 chromatography. The relative amounts of tRNAphe, t...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/8.15.3467

    authors： Lin VK,Agris PF

    更新日期：1980-08-11 00:00:00

  • A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells.

    abstract：:RNA:5-methylcytosine (m5C) methyltransferases are currently the focus of intense research following a series of high-profile reports documenting their physiological links to several diseases. However, no methods exist which permit the specific analysis of RNA:m5C methyltransferases in cells. Herein, we described how a...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkz1047

    authors： Yang T,Low JJA,Woon ECY

    更新日期：2020-01-10 00:00:00

  • Bovine Genome Database: new annotation tools for a new reference genome.

    abstract：:The Bovine Genome Database (BGD) (http://bovinegenome.org) has been the key community bovine genomics database for more than a decade. To accommodate the increasing amount and complexity of bovine genomics data, BGD continues to advance its practices in data acquisition, curation, integration and efficient data retrie...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkz944

    authors： Shamimuzzaman M,Le Tourneau JJ,Unni DR,Diesh CM,Triant DA,Walsh AT,Tayal A,Conant GC,Hagen DE,Elsik CG

    更新日期：2020-01-08 00:00:00

  • Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution.

    abstract：:Directed molecular evolution and combinatorial methodologies are playing an increasingly important role in the field of protein engineering. The general approach of generating a library of partially randomized genes, expressing the gene library to generate the proteins the library encodes and then screening the protei...

    journal_title：Nucleic acids research

    pub_type： 杂志文章,评审

    doi：10.1093/nar/gkh315

    authors： Neylon C

    更新日期：2004-02-27 00:00:00

  • Raman spectral studies of nucleic acids. XVII. Conformational structures of polyinosinic acid.

    abstract：:Laser-Raman spectra of poly(rI) show the formation of an ordered complex in aqueous solutions of high ionic strength. This structure exhibits the A-helix geometry, contains stacked bases and is apparently stabilized by specific hydrogen bonding involving hypoxanthine C6=0 groups. Thermal dissociation of the poly(rI) c...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/4.7.2407

    authors： Chou CH,Thomas GJ Jr,Arnott S,Smith PJ

    更新日期：1977-07-01 00:00:00

  • High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres.

    abstract：:Accurate maps and DNA sequences for human subtelomere regions, along with detailed knowledge of subtelomere variation and long-range telomere-terminal haplotypes in individuals, are critical for understanding telomere function and its roles in human biology. Here, we use a highly automated whole genome mapping technol...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkx017

    authors： Young E,Pastor S,Rajagopalan R,McCaffrey J,Sibert J,Mak ACY,Kwok PY,Riethman H,Xiao M

    更新日期：2017-05-19 00:00:00

  • WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway.

    abstract：:The centromere is a highly specialized chromosomal element that is essential for chromosome segregation during mitosis. Centromere integrity must therefore be properly preserved and is strictly dependent upon the establishment and maintenance of surrounding chromatin structure. Here we identify WDHD1, a WD40-domain an...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkq1338

    authors： Hsieh CL,Lin CL,Liu H,Chang YJ,Shih CJ,Zhong CZ,Lee SC,Tan BC

    更新日期：2011-05-01 00:00:00

  • Analysis of the proximal transcriptional element of the myelin basic protein gene.

    abstract：:The gene encoding myelin basic protein (MBP) contains multiple activator sequences spanning upstream of its transcriptional initiation site which differentially promote transcription in glial cells. The proximal activator sequence, designated MB1, activates transcription in a glial cell type specific manner. This sequ...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/20.3.545

    authors： Devine-Beach K,Haas S,Khalili K

    更新日期：1992-02-11 00:00:00

  • Subtractive cDNA cloning using oligo(dT)30-latex and PCR: isolation of cDNA clones specific to undifferentiated human embryonal carcinoma cells.

    abstract：:The human embryonal carcinoma cell line NEC14 can be induced to differentiate by the addition of 10(-2)M N,N'-hexamethylene-bis-acetamide (HMBA). A subtractive cDNA library specific to undifferentiated NEC14 cells was constructed using oligo(dT)30-Latex and polymerase chain reaction (PCR). The method was designed to i...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/19.25.7097

    authors： Hara E,Kato T,Nakada S,Sekiya S,Oda K

    更新日期：1991-12-01 00:00:00

  • The B-WICH chromatin-remodelling complex regulates RNA polymerase III transcription by promoting Max-dependent c-Myc binding.

    abstract：:The chromatin-remodelling complex B-WICH, comprised of William syndrome transcription factor, the ATPase SNF2h and nuclear myosin, specifically activates RNA polymerase III transcription of the 5S rRNA and 7SL genes. However, the underlying mechanism is unknown. Using high-resolution MN walking we demonstrate here tha...

    journal_title：Nucleic acids research

    pub_type： 杂志文章

    doi：10.1093/nar/gkv312

    authors： Sadeghifar F,Böhm S,Vintermist A,Östlund Farrants AK

    更新日期：2015-05-19 00:00:00