Long W tracts are over-represented in the Escherichia coli and Haemophilus influenzae genomes.

Abstract:

:The occurrence of DNA tracts of the three binary base combinations: R.Y, K.M and W;S has been mapped in the complete genomes of Haemophilus influenzae and Escherichia coli. A highly significant over-representation of W tracts is observed in both bacteria. The excess of W tracts is particularly striking in the 10% intercoding regions. Subdivision of intercoding regions into divergent (promoting), convergent (terminating) and sequential subregions shows that the excess of W tracts is most concentrated in the promoter regions. A particularly high excess of W tracts is observed in the first 200 bases 5' upstream of coding start sites. The data suggest that W tracts have a role in promoter function. A function as unwinding centers, analogous to the role of R.Y tracts in eukaryotes, is proposed. R.Y and K.M tracts are only modestly over-represented in the two bacteria.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Shomer B,Yagil G

doi

10.1093/nar/27.22.4491

keywords:

subject

Has Abstract

pub_date

1999-11-15 00:00:00

pages

4491-500

issue

22

eissn

0305-1048

issn

1362-4962

pii

gkc642

journal_volume

27

pub_type

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