Abstract:
OBJECTIVE:To investigate the morbidity and mortality after radical prostatectomy (RP) in relation to the numbers of RPs carried out at individual hospitals, as recent studies of complex surgery report worse outcomes in low-volume hospitals, and there has been a large increase in RPs for localized prostate cancer. METHODS:We analysed hospital episode statistics data for all 18 027 RPs in English National Health Service hospitals between 1997 and 2004. RESULTS:In multivariate analysis, there was a U-shaped association of hospital volume with mortality (P for nonlinear trend, 0.004), but this finding was based on only 59 (0.3%) deaths. The mean length of stay was 6 days and decreased by 2.96% (95% confidence interval, CI, 1.98-3.92; P < 0.001) per quintile increase in hospital volume. In all, 16.1% of men had 30-day in-hospital complications; 20.3% were readmitted with complications within a year. The odds of 30-day in-hospital wound/bleeding complications decreased by 6% (95% CI 1-11; P = 0.02), and miscellaneous medical complications decreased by 10% (0-19; P = 0.04) per increase in hospital volume quintile. For re-admissions within a year, the hazard of vascular complications decreased by 15% (6-22; P = 0.001), wound/bleeding complications decreased by 8% (2-13; P = 0.01) and genitourinary complications decreased by 5% (2-8; P = 0.002), per increase in hospital volume quintile. CONCLUSION:In men undergoing RP the length of hospital stay and rates of some short- and long-term postoperative complications afterward are lower in high-volume hospitals. The magnitudes of these effects on the outcomes studied may be too small and inconsistent to indicate a policy of selective referral to high-volume hospitals. Quality of life and oncological outcomes, however, could not be investigated in this dataset.
journal_name
BJU Intjournal_title
BJU internationalauthors
Judge A,Evans S,Gunnell DJ,Albertsen PC,Verne J,Martin RMdoi
10.1111/j.1464-410X.2007.07118.xsubject
Has Abstractpub_date
2007-11-01 00:00:00pages
1040-9issue
5eissn
1464-4096issn
1464-410Xpii
BJU7118journal_volume
100pub_type
杂志文章abstract::Docetaxel-based therapy is established as the standard first-line chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), based on results from two landmark Phase III studies. However, prognosis remains poor, with a median survival of less than 2 years. There is no standard of care for p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10036.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To report our experience of 11 children with pelvi-ureteric junction obstruction (PUJO) in a duplex kidney and to review previous reports. PATIENTS AND METHODS:From 1995 to 2005 the second author (G.H.H.S.) performed 145 pyeloplasties in single-system kidneys and in 11 children with PUJO in a duplex kidney. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To determine whether clinicians discuss bone-specific side-effects with patients on androgen-deprivation therapy (ADT) for prostate cancer, or prescribe lifestyle and pharmacological interventions for low bone mineral density (BMD), as decreased BMD is a common side-effect of ADT, leading to increased risk of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08156.x
更新日期:2009-03-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Patient-reported quality of life (QoL) in prostate cancer is recognized as an important outcome, and has been shown in multiple studies to capture the incidence and timing of patient symptoms more acc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11117.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To determine whether conformity to standard recommendations of retroperitoneal lymph node dissection (RPLND) after chemotherapy for testicular and primary retroperitoneal nonseminomatous germ cell tumours (NSGCT) and completeness of surgical excision have an effect on oncological outcome. PATIENTS AND METHOD...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09175.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To present the perioperative outcomes from the British Association of Urological Surgeons (BAUS) nephrectomy dataset for 2012, the first year of public reporting of individual surgeon outcomes in the UK. PATIENTS AND METHODS:All nephrectomies performed in the year 2012 and recorded in the database were analy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12770
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00140.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:To assess the oucomes of penile prosthesis (PP) implantation after total phallic reconstruction secondary to gender dysphoria. PATIENTS AND METHODS:We conducted a retrospective single-centre analysis of 247 consecutive patients. The recruitment period was January 2001 to October 2015. A total of 328 inflata...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14027
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility and efficacy of suicide-gene therapy using adenovirus (Ad)-mediated herpes simplex virus thymidine kinase (HSV-TK) and the prodrug acyclovir, and to evaluate changes in the biological phenotype for tumour cell proliferative activity after suicide-gene therapy in animal models of ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00516.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To compare high-power holmium laser lithotripsy (HP-HLL) and ultrasonic lithotripsy (US-L) for disintegration of staghorn stones during percutaneous nephrolithotomy (PCNL). PATIENTS AND METHODS:A non-inferiority randomised controlled trial was conducted between August 2011 and September 2014. Inclusion crite...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.13418
更新日期:2016-08-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: For patients who are unfit for extirpative surgery, percutaneous cryoablation (PCA) presents a minimally-invasive alternative for the treatment of renal masses. PCA has been demonstrated to be safe, with complication rates <10% being reported consist...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11432.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To describe our current procedure of robot-assisted laparoscopic radical prostatectomy (RALP), and to assess the effect of the learning curve on perioperative data, early oncological outcomes and functional results, as RALP has increasingly become a treatment option for men with localized prostate cancer. PA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09013.x
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To assess the use of sodium pentosan polysulphate (SPP) for haemorrhagic cystitis (HC), a potentially life-threatening side-effect in patients treated with pelvic radiotherapy or cyclophosphamide, and which can be difficult to manage as patients often have significant comorbidity. PATIENTS AND METHODS:Betwee...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05044.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To investigate the effect on cancer detection by varying the number of cores taken for prostate biopsy according to the size of the prostate. PATIENTS AND METHODS:A retrospective review of a prospectively registered prostate biopsy database identified 3040 consecutive patients undergoing prostate biopsy at a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10239.x
更新日期:2011-11-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (outcomes) Level of Evidence 2a. What's known on the subject? and What does the study add? Erectile dysfunction (ED) is a well known implication of radical prostatectomy (RP). Despite the search for technical improvement in the surgical procedure (e.g. nerve-sparing surgery, robot-assiste...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11484.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To present early outcome data from patients treated for invasive penile cancers with organ-sparing surgery, as the treatment of such malignancies has traditionally either been amputative surgery or radical radiotherapy, both associated with significant physical and psychosexual morbidity. PATIENTS AND METHOD...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05153.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08359.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To investigate the long-term outcomes of laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS:In all, 1138 patients underwent LRP during a 163-month period from 2000 to 2008, of which 51.5%, 30.3% and 18.2% were categorised into D'Amico risk groups of low-, intermediate- and high-risk, respectivel...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12887
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To determine the risk of COVID-19 transmission during minimally invasive surgical (MIS) procedures METHODS: Surgical society statements regarding the risk of COVID transmission during MIS procedures were reviewed. In addition, the available literature on COVID-19 and other viral transmission in CO2 pneumoper...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.15105
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To identify predictors of delayed therapy with curative intent, an increasingly common option in contemporary patients with prostate cancer who initially choose watchful waiting. PATIENTS AND METHODS:The characteristics of all patients at one institution and diagnosed with T1-4NXM0 prostate cancer between 19...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04669.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To review the results of repairing a parastomal hernia after ileal conduit formation, using the lateral approach. PATIENTS AND METHODS:We retrospectively assessed 18 patients (9%) who developed a parastomal hernia, from 211 who had an ileal conduit created between 1982 and 2001; 15 had a surgical repair usin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05008.x
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To describe a previously unreported complication (severe perineal pain) after bladder reconstruction and enterocystoplasty in patients with bladder exstrophy. PATIENTS AND METHODS:The notes were reviewed retrospectively for four patients (two boys and two girls) with classical bladder exstrophy who had sever...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2003.04741.x
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:• Obesity induced by high-fat diet (HFD) is one of the most important risk factor for the development of erectile dysfunction (ED) in man. This study aimed to characterize the ED resulting from obesity associated with HFD in mice. MATERIALS AND METHODS:• C57BL/6 mice fed for 10 weeks with either HFD to induc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09704.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To determine if the adjunctive use of power Doppler imaging (PDI) could provide prognostic utility in the treatment of prostate cancer, as an accurate prediction of the clinical behaviour of prostate cancer is important to determine appropriate treatment. PATIENTS AND METHODS:Most centres rely on a digital r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08958.x
更新日期:2010-05-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does the study add? Men with prostate cancer have higher rates of non-cancer mortality and CV morbidity and some of that excess risk has been attributed to the treatment they receive. ADT is an established treatment option ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10555.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To determine, in a population-based cohort, if disease-specific survival (DSS) was equivalent in patients undergoing ablation vs nephron-sparing surgery (NSS) for clinical stage T1a renal cell carcinoma (RCC). PATIENTS AND METHODS:A retrospective cohort study was performed using patients from the Surveillanc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11113.x
更新日期:2012-11-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10813.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To determine whether heat, used in transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia and which causes necrotic lesions within the adenoma, induces apoptosis in benign human prostatic stromal cells. Materials and methods Prostatic stromal cells were cultured from benign human prosta...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00473.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06478.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the relevance of ureterocele ectopia and associated reflux on the outcome of duplex system ureteroceles (DSU) after neonatal transurethral incision (TUI). PATIENTS AND METHODS:The study included 41 neonates with a diagnosis of DSU; the ureterocele was ectopic in 24 (58%). Before TUI, vesico-urete...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04861.x
更新日期:2004-06-01 00:00:00