Abstract：
:Because of the increase in the use of warfarin in the population in recent years, reversal of warfarin-related coagulopathy has become common in daily hospital practice. Transfusion of fresh frozen plasma (FFP) is the preferred treatment method for urgent warfarin reversal in the USA. We have undertaken a 1-month audit of FFP usage to ascertain the impact of warfarin use on the consumption of FFP. Sixty percent of the 376 units of FFP that were transfused during the study month were used to reverse warfarin effects. The most common reason to reverse warfarin was bleeding. Thirty-three percent of the units were used for the treatment of other coagulopathies, 7% were used in therapeutic plasmapheresis, and <1% was transfused empirically. One hundred and eighteen patients received FFP during the study month. The study population consisted mostly of elderly patients (65%); however, the warfarin reversing patients consisted disproportionately more of elderly patients (75%) compared with patients receiving FFP for other reasons (46%) (P = 0.0032). Warfarin reversal emerged as the major indication for FFP use in this study. Blood banks of hospitals serving a predominantly elderly patient population should anticipate a higher consumption of FFP. Careful monitoring of warfarin therapy, stringent implementation of the warfarin reversal guidelines, and the introduction of newer products for warfarin reversal would help reduce the consumption of FFP.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Ozgonenel B,O'Malley B,Krishen P,Eisenbrey ABdoi
10.1002/ajh.20902subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1091-4issue
12eissn
0361-8609issn
1096-8652journal_volume
82pub_type
杂志文章abstract：:This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose receiv...
journal_title：American journal of hematology
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更新日期：2015-04-01 00:00:00
abstract：:Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and is associated with a favorable prognosis. While previous studies have evaluated NPM1 in a binary fashion, we recently demonstrated a significant independent negative prognostic effect of hig...
journal_title：American journal of hematology
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更新日期：2019-08-01 00:00:00
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journal_title：American journal of hematology
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更新日期：1988-03-01 00:00:00
abstract：:Severe chronic neutropenia (SCN) is defined as an absolute neutrophil (ANC) of less than 0.5 x 10(9)/L, lasting for months or years. Congenital, cyclic, and idiopathic neutropenia are principal categories of SCN. Since 1994, the Severe Chronic Neutropenia International Registry (SCNIR) has collected data to monitor th...
journal_title：American journal of hematology
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更新日期：2003-02-01 00:00:00
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更新日期：2006-12-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章,评审
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更新日期：2017-12-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
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journal_title：American journal of hematology
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
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更新日期：1987-07-01 00:00:00
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journal_title：American journal of hematology
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更新日期：1997-04-01 00:00:00
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journal_title：American journal of hematology
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journal_title：American journal of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1002/ajh.20944
更新日期：2007-11-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：American journal of hematology
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更新日期：2006-11-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
doi：10.1002/ajh.23499
更新日期：2013-09-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
doi：10.1002/ajh.1186
更新日期：2001-12-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
doi：10.1002/(SICI)1096-8652(199610)53:2<72::AID-AJH3>3
更新日期：1996-10-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章
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journal_title：American journal of hematology
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
abstract：:Fetal calf serum (FCS) is used as a component of the media for cells grown in culture. However, the high cost of FCS has stimulated a search for a possible alternative. Approximately 10% of human platelet concentrates prepared for clinical transfusions are outdated. Sera prepared from platelet concentrates were compar...
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journal_title：American journal of hematology
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journal_title：American journal of hematology
pub_type： 临床试验,杂志文章
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abstract：:Nucleotide sequence analysis of the 5' beta-globin gene flanking region has been carried out for numerous homozygous beta-thalassemia patients with different mutations and of various ethnic backgrounds. Four different rearrangements were found associated with numerous beta-thalassemia mutations. The (AT)X(T)Y repeat m...
journal_title：American journal of hematology
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journal_title：American journal of hematology
pub_type： 杂志文章
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更新日期：1993-08-01 00:00:00
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journal_title：American journal of hematology
pub_type： 杂志文章,评审
doi：10.1002/ajh.2830370110
更新日期：1991-05-01 00:00:00
abstract：:We have generated a murine hybridoma that secretes a monoclonal antibody (mAb) that is highly specific for hemoglobin C (HbC) [alpha 2 beta 2 6(A3)Glu----Lys] and shows no cross reactivity with HbA, HbA2, HbF, HbS, HbE, or Hb O-Arab. Using this antibody, we developed a simple and rapid enzyme linked immunosorbent assa...
journal_title：American journal of hematology
pub_type： 杂志文章
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更新日期：1990-03-01 00:00:00
abstract：:A 28-year-old asymptomatic male of Iranian Jewish (Meshadi) heritage was found on routine exam to have an erythrocytosis (RBC = 6.22 x 10(12)/l, Hgb = 19.2 g/dl, Hct = 58.9%). Splenomegaly was absent on physical exam. There was no family history of erythrocytosis. His oxygen dissociation curve was left-shifted with a ...
journal_title：American journal of hematology
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更新日期：2004-04-01 00:00:00
