Abstract：
:The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing plasma ghrelin in PWS patients, which would influence appetite. This study investigated the degree of ghrelin suppression using an euglycemic hyperinsulinemic clamp in children with PWS (n=6) and normal children (n=6). After a 90-min infusion of insulin, the plasma ghrelin level decreased from a basal value of 0.86+/-0.15 to 0.58+/-0.12 ng/mL in the controls, and from 2.38+/-0.76 to 1.12+/-0.29 ng/mL in children with PWS (p=0.011). The area under the curve below the baseline level over the 90 min insulin infusion was larger in children with PWS than in controls (-92.82+/-44.4 vs. -10.41+/-2.87 ng/mL/90 min) (p=0.011). The insulin sensitivity measured as the glucose infusion rate at steady state was similar in the two groups (p=0.088). The decrease in the ghrelin levels in response to insulin was more pronounced in the children with PWS than in the controls. However, the level of ghrelin was always higher in the children with PWS during the clamp study. This suggests that even though insulin sensitivity to ghrelin is well maintained, an increase in the baseline ghrelin levels is characteristic of PWS.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Paik KH,Lee MK,Jin DK,Kang HW,Lee KH,Kim AH,Kim C,Lee JE,Oh YJ,Kim S,Han SJ,Kwon EK,Choe YHdoi
10.3346/jkms.2007.22.2.177subject
Has Abstractpub_date
2007-04-01 00:00:00pages
177-82issue
2eissn
1011-8934issn
1598-6357pii
200704177journal_volume
22pub_type
杂志文章abstract：:Development of a cystic mass on the nasal dorsum is a very rare complication of aesthetic rhinoplasty. Most reported cases are of mucous cyst and entrapment of the nasal mucosa in the subcutaneous space due to traumatic surgical technique has been suggested as a presumptive pathogenesis. Here, we report a case of dors...
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pub_type： 杂志文章
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journal_title：Journal of Korean medical science
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pub_type： 杂志文章,多中心研究
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