1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis.


BACKGROUND:Immune cells express the vitamin (vit) D receptor, and vit D is a potent immune-modulator. A negative correlation between serum vit D levels and rheumatoid arthritis (RA) disease activity has been reported. Therefore, we aimed to investigate if the sufficient serum vit D level is helpful to control disease activity in RA patients treated with interleukin (IL)-6 receptor antibody tocilizumab. METHODS:RA patients taking tocilizumab were enrolled, and data were collected retrospectively. Disease activity scores (DAS) 28, serum vit D levels, modified Sharp scores of hand X-ray at the time of tocilizumab initiation, and follow-up data were analysed. Peripheral blood mononuclear cells were differentiated into T-helper (Th) 17 or osteoclasts in the presence of various concentrations of tocilizumab and/or 1,25(OH)₂D. Th17 proportions were analysed by fluorescence-activated cell sorting. Supernatant cytokine levels were determined by enzyme-linked immunosorbent assay. RESULTS:Among 98 RA patients taking tocilizumab, 34 (34.7%) had sufficient serum 25(OH)D levels (≥ 30 ng/mL) when tocilizumab was initiated. At 24 weeks, vit D sufficient patients had greater DAS28 reduction (64.6% ± 15.5% vs. 52.7% ± 20.7%, P = 0.004), and lower disease activity (91.2% vs. 70.3%, P = 0.018) or remission (82.4% vs. 57.8%, P = 0.014). These differences in DAS28 reduction and the proportion of patients with remission persisted at 48 weeks. However, there was no significant difference in hand and wrist erosion progression. In vitro, tocilizumab and 1,25(OH)₂D treatment synergistically suppressed IL-17 production and osteoclastogenesis. CONCLUSION:RA patients treated with IL-6 antibody show a better response when they have sufficient serum vit D. Tocilizumab and 1,25(OH)₂D synergistically suppress IL-17 production and osteoclast differentiation in RA patients.


J Korean Med Sci


Kim H,Baek S,Hong SM,Lee J,Jung SM,Lee J,Cho M,Kwok SK,Park SH




Has Abstract


2020-02-17 00:00:00














  • Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients.

    abstract::Vascular endothelial growth factor (VEGF) is a multi-functional cytokine involved in inflammation, repair and angiogenesis in asthmatic airway. This study aimed to evaluate the role of VEGF in immediate bronchoconstriction induced by TDI inhalation, and in chronic TDI-asthma patients. 11 newly diagnosed TDI-asthma pat...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Choi JH,Suh YJ,Lee SK,Suh CH,Nahm DH,Park HS

    更新日期:2004-06-01 00:00:00

  • Autoimmune oophoritis--a case report.

    abstract::A case is described of an autoimmune oophoritis that was diagnosed unexpectedly after a hysterectomy and bilateral salpingo-oophorectomy had been performed on the suspicion of ovarian cysts. The patient was a 43-year-old multiparous woman who presented with vaginal bleeding and lower abdominal pain which she had had f...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Suh YL

    更新日期:1992-09-01 00:00:00

  • Cancer in patients on chronic dialysis in Korea.

    abstract::The study of cancer in patients treated with dialysis in Korea has not been reported. The aim of this study was to investigate the incidence and mortality of cancer among patients on dialysis in Korea. The study subjects were 106 cancer patients (2.3%) out of 4,562 end-stage renal disease (ESRD) patients maintained on...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Lee JE,Han SH,Cho BC,Park JT,Yoo TH,Kim BS,Park HC,Kang SW,Lee HY,Han DS,Ha SK,Choi KH

    更新日期:2009-01-01 00:00:00

  • Index of microcirculatory resistance as predictor for microvascular functional recovery in patients with anterior myocardial infarction.

    abstract::IMR is useful for assessing the microvascular dysfunction after primary percutaneous coronary intervention (PCI). It remains unknown whether index of microcirculatory resistance (IMR) reflects the functional outcome in patients with anterior myocardial infarction (AMI) with or without microvascular obstruction (MO).Th...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Yoo SH,Yoo TK,Lim HS,Kim MY,Koh JH

    更新日期:2012-09-01 00:00:00

  • Predictable ultrasonographic findings of early abortion.

    abstract::Early fetal growth delay and early oligohydramnios have been suspected as signs of embryonal jeopardy. However, little information is available for the prediction of early abortion. Sonographic examination of 111 early pregnancies between the sixth and ninth gestational week with regular, 28 day menstrual cycles was p...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Jun SA,Ahn MO,Lee YD,Cha KY

    更新日期:1992-03-01 00:00:00

  • Carpal tunnel syndrome and peripheral polyneuropathy in patients with end stage kidney disease.

    abstract::This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis (HD) and 48 on peritoneal dialysis (PD), were enrolled. The duration of ESKD and dialysis, the site of the arterioveno...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kwon HK,Pyun SB,Cho WY,Boo CS

    更新日期:2011-09-01 00:00:00

  • The tumor necrosis factor beta * 1 allele is linked significantly to HLA-DR8 in Koreans with atrophic autoimmune thyroiditis who are positive for thyrotropin receptor blocking antibody.

    abstract::The localization and functional characteristics of tumor necrosis factor(TNF) beta gene raise the possibility that it may be involved in the susceptibility to autoimmune thyroid diseases. To investigate whether a TNF beta gene polymorphism is associated with autoimmune thyroiditis, we analyzed the TNF beta gene polymo...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章


    authors: Chung JH,Cho BY,Lee HK,Kim TG,Han H,Koh CS

    更新日期:1994-04-01 00:00:00

  • Comparative Research for the Healthcare Budget and Burden of Disease in Perspective Resource Allocation.

    abstract:Background:Burden of disease can be used to prioritize the healthcare budget allocation. We analyzed the research and development (R&D) budget of the Ministry of Health and Welfare (MOHW) in 2018 and compared the results with those of the 2015 Korean National Burden of Disease (KNBD) study. Methods:The 2018 MOHW R&D P...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Park SY,Yoon SJ,Park H,Jo MW,Oh IH

    更新日期:2019-03-07 00:00:00

  • Two novel mutations in the C7 gene in a Korean patient with complement C7 deficiency.

    abstract::Complement C7 deficiency is an autosomal recessive disorder well known to be associated with increased susceptibility to meningococcal infection and has mostly been reported in Caucasians. In the Korean population, no case of C7 deficiency has been reported to date. Recently we experienced an 11-yr-old girl with menin...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Ki CS,Kim JW,Kim HJ,Choi SM,Ha GY,Kang HJ,Kim WD

    更新日期:2005-04-01 00:00:00

  • Study on chemoprevention of hepatocellular carcinoma by ginseng: an introduction to the protocol.

    abstract::In patients with chronic hepatitis C virus disease, there is a high incidence of development of hepatocellular carcinoma (HCC) in the process of transition from chronic hepatitis to hepatic cirrhosis. Although ginseng traditionally has been used mainly as a nutritional supplement in Asian countries, a case-control stu...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Ginseng-HCC Chemopreventive Study Osaka Group.

    更新日期:2001-12-01 00:00:00

  • Cowden's disease--a report on the first case in Korea and literature review.

    abstract::Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 32-year-old man with oral mucosal papillomatosis and plantar hyperkeratosis as a definite case of Cowden's...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,评审


    authors: Lee HR,Moon YS,Yeom CH,Kim KW,Chun JY,Kim HK,Choi HS,Kim DK,Chung TS

    更新日期:1997-12-01 00:00:00

  • Influenza Vaccination Coverage and Its Associated Factors among North Korean Defectors Living in the Republic of Korea.

    abstract::This study aimed to examine influenza vaccination coverage of North Korean defectors (NKD) in the Republic of Korea (Korea) and explore the factors affected the vaccination coverage. Total 378 NKD were analyzed. Four Korean control subjects were randomly matched by age and gender from the Korea National Health and Nut...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Song IG,Lee H,Yi J,Kim MS,Park SM

    更新日期:2015-09-01 00:00:00

  • X-linked hyper-IgM syndrome associated with Cryptosporidium parvum and Cryptococcus neoformans infections: the first case with molecular diagnosis in Korea.

    abstract::X-linked hyper-IgM syndrome (XHIM) is a rare primary immunodeficiency disorder, caused by mutations of the gene encoding CD40 ligand (CD40L; CD154). We report the clinical manifestations and mutational analysis of the CD40L gene observed in a male patient from a XHIM family. Having hypogammaglobulinemia and elevated I...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Jo EK,Kim HS,Lee MY,Iseki M,Lee JH,Song CH,Park JK,Hwang TJ,Kook H

    更新日期:2002-02-01 00:00:00

  • Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea.

    abstract::Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter in Korea that operated from 1936 to 1989. This study was conducted to evaluate the level of exposure to toxic metals and the potential effect on health in people living near the smelter. The study included 572 ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kim YD,Eom SY,Yim DH,Kim IS,Won HK,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

    更新日期:2016-04-01 00:00:00

  • A clinicopathological study of unsuspected carcinoma of the gallbladder.

    abstract::We investigated the incidence of unsuspected gallbladder (GB) carcinomas in a total of 527 consecutive GB specimens resected for benign biliary disease and their clinicopathological features. The GBs were examined microscopically using stepwise tissue sections at 5 mm interval. Clinical and pathological findings were ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kwon SY,Chang HJ

    更新日期:1997-12-01 00:00:00

  • The increase in hepatic uncoupling by fenofibrate contributes to a decrease in adipose tissue in obese rats.

    abstract::Fenofibrate is a drug that has been suggested to inhibit weight gain by increasing the catabolism of fatty acid in the hepatic mitochondria. We hypothesized that fenofibrate induces an increase in energy expenditure in the hepatic mitochondria, which results in the reduction of adipose tissue. In this study we measure...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Park MK,Lee HJ,Hong SH,Choi SS,Yoo YH,Lee KI,Kim DK

    更新日期:2007-04-01 00:00:00

  • Compound nerve action potential of common peroneal nerve and sural nerve action potential in common peroneal neuropathy.

    abstract::To enhance the accuracy for determining the precise localization, the findings of the compound nerve action potentials (CNAPs) of the common peroneal nerve (CPN) were investigated in patients with common peroneal mononeuropathy (CPM) in the knee, and the sural sensory nerve action potentials (SNAPs) were also analyzed...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kwon HK,Kim L,Park YK

    更新日期:2008-02-01 00:00:00

  • Clinicopathological aspects of 542 cases of pancreatic cancer: a special emphasis on small pancreatic cancer.

    abstract::Small pancreatic cancers (longest diameter

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Jung KW,Kim MH,Lee TY,Kwon S,Oh HC,Lee SS,Seo DW,Lee SK

    更新日期:2007-09-01 00:00:00

  • Prevalence and Risk Factors of Gastric and Colorectal Cancer after Cholecystectomy.

    abstract:BACKGROUND:Previous studies on the relationship between gastrointestinal (GI) cancer and cholecystectomy remain inconclusive. We aimed to evaluate this relationship, albeit particularly between cholecystectomy and gastric cancer or colorectal cancer (CRC), and the risk factors of cancer among individuals who have under...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kim SB,Kim KO,Kim TN

    更新日期:2020-11-02 00:00:00

  • The first reported case of West Nile encephalitis in Korea.

    abstract::West Nile encephalitis was first identified in 1937, but until now, it was never diagnosed in Korea. A 58-yr-old Korean man was admitted with headache and cognitive dysfunction. The patient had been on a business trip in Guinea. Cerebrospinal fluid (CSF) showed pleocytosis. The patient complained of both leg weakness,...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Hwang J,Ryu HS,Kim H,Lee SA

    更新日期:2015-03-01 00:00:00

  • Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea.

    abstract::We investigated recent epidemiologic trends regarding campylobacteriosis vs. nontyphoidal salmonellosis (NTS), a previously known leading cause of bacterial enterocolitis in Korean children. Among 363 hospitalized children with acute inflammatory diarrhea, Campylobacter (18.7%) was the most frequently detected pathoge...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Shim JO,Chang JY,Kim A,Shin S

    更新日期:2017-07-01 00:00:00

  • Add-on Eye Movement Desensitization and Reprocessing (EMDR) Therapy for Adults with Post-traumatic Stress Disorder Who Failed to Respond to Initial Antidepressant Pharmacotherapy.

    abstract::This study examined the add-on efficacy of eye movement desensitization and reprocessing (EMDR) therapy among adult civilians with post-traumatic stress disorder (PTSD) who continued to be symptomatic after more than 12 weeks of initial antidepressant treatment. Scores for the Clinician Administered PTSD Scale (CAPS) ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Bae H,Kim D,Cho Y,Kim D,Kim SH

    更新日期:2018-11-05 00:00:00

  • Clinicopathologic comparison of eroded polypoid hyperplasia and solitary rectal ulcer syndrome.

    abstract::We experienced two unusual cases of tumor-like polypoid lesions involving the rectosigmoid colon. They could not be readily classified into any well known polypoid tumors of the rectosigmoid colon, but appeared to have some similarities to the previously documented "eroded polypoid hyperplasia (EPH)". A collective rev...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Cho NH,Park CI,Ahn HJ

    更新日期:1994-08-01 00:00:00

  • Human herpesvirus 8 in Kaposi's sarcoma and Kaposi's sarcoma-mimicking vascular tumors.

    abstract::Kaposi's sarcoma (KS) had been a rare and unusual vascular tumor until a recent epidemic of a disseminated and fulminant form of KS in AIDS patients. Infectious agents have been suspected of causing KS, and recently partial genomic DNA sequences of human herpesvirus 8 (HHV8) have been identified in AIDS-associated KS ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kang GH,Kwon GY,Kim CW

    更新日期:1998-02-01 00:00:00

  • Pretransplant Hepatic Malignancy Increases Risk of De Novo Malignancy after Liver Transplantation.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) recurrence and development of de novo malignancy (DNM) after liver transplantation (LT) are the major causes of late recipient death. METHODS:We analyzed the incidence of extrahepatic DNM following living donor LT according to the status of pretransplant hepatic malignancy. We...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Park GC,Hwang S,Ahn CS,Kim KH,Moon DB,Ha TY,Song GW,Jung DH,Yoon YI,Cho HD,Kwon JH,Chung YK,Kang SH,Choi JU,Jung IJ,Lee SG

    更新日期:2020-03-23 00:00:00

  • Association between Genetic Variations of MERTK and Chronic Obstructive Pulmonary Disease in Koreans.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease. To date, a large number of clinical studies have been conducted to investigate the association between genetic variations and COPD. However, little is known regarding the genetic susceptibility of Koreans to this disease. MER recept...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kim WJ,Park HJ,Choi YJ,Kwon EY,Kim BM,Lee JH,Chang JH,Lee Kang J,Choi JH

    更新日期:2018-02-12 00:00:00

  • Screening of subtelomeric rearrangements in 100 Korean Pediatric patients with unexplained mental retardation and anomalies using subtelomeric FISH (fluorescence in situ hybridization).

    abstract::Rearrangements of the subtelomeric regions of chromosomes account for a significant proportion of the underlying genetic defects in both idiopathic mental retardation (MR) and multiple congenital anomalies. To detect the rearrangements, a set of subtelomeric fluorescence in situ hybridization (FISH) probes has been de...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Park HK,Kim HJ,Kim HJ,Han SH,Kim YJ,Kim SH

    更新日期:2008-08-01 00:00:00

  • The Clinical Outcomes of Lower Gastrointestinal Bleeding Are Not Better than Those of Upper Gastrointestinal Bleeding.

    abstract::The incidence of lower gastrointestinal bleeding (LGIB) is increasing; however, predictors of outcomes for patients with LGIB are not as well defined as those for patients with upper gastrointestinal bleeding (UGIB). The aim of this study was to identify the clinical outcomes and the predictors of poor outcomes for pa...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Kwak MS,Cha JM,Han YJ,Yoon JY,Jeon JW,Shin HP,Joo KR,Lee JI

    更新日期:2016-10-01 00:00:00

  • Spinal cord injury markedly altered protein expression patterns in the affected rat urinary bladder during healing stages.

    abstract::The influence of spinal cord injury (SCI) on protein expression in the rat urinary bladder was assessed by proteomic analysis at different time intervals post-injury. After contusion SCI between T9 and T10, bladder tissues were processed by 2-DE and MALDI-TOF/MS at 6 hr to 28 days after SCI to identify proteins involv...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Lee JY,Kim BJ,Sim G,Kim GT,Kang D,Jung JH,Hwa JS,Kwak YJ,Choi YJ,Park YS,Han J,Lee CS,Kang KR

    更新日期:2011-06-01 00:00:00

  • Optimal waist circumference cutoff values for metabolic syndrome diagnostic criteria in a Korean rural population.

    abstract::The Korean Society for the Study of Obesity (KSSO) has defined the waist circumference cutoff value of central obesity as 90 cm for men and 85 cm for women. The purpose of this investigation was to determine the corresponding waist circumference values. A total of 3,508 persons in the Korean Rural Genomic Cohort Study...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章


    authors: Koh JH,Koh SB,Lee MY,Jung PM,Kim BH,Shin JY,Shin YG,Ryu SY,Lee TY,Park JK,Chung CH

    更新日期:2010-05-01 00:00:00