Abstract:
:Histiocytic sarcoma (HS) is a very rare neoplasm that often shows an aggressive clinical course and systemic symptoms, such as fever, weight loss, adenopathy, hepatosplenomegaly and pancytopenia. It may present as localized or disseminated disease. We describe here a 63-yr-old male who manifested systemic symptoms, including fever, weight loss and generalized weakness. Abdominal and chest computed tomography failed to show specific findings, but there was suspicion of multiple bony changes at the lumbar spine. Fusion whole body positron emission tomography, bone scan and lumbar spine magnetic resonance imaging showed multiple bone lesions, suggesting a malignancy involving the bone marrow (BM). Several BM and bone biopsies were inconclusive for diagnosis. Necropsy showed replacement of the BM by a diffuse proliferation of neoplastic cells with markedly increased cellularity (95%). The neoplastic cells were positive for lysozyme and CD68, but negative for T- and B-cell lineage markers, and megakaryocytic, epithelial, muscular and melanocytic markers. Morphologic findings also distinguished it from other dendritic cell neoplasms.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Sohn BS,Kim T,Kim JE,Bae E,Park CJ,Huh J,Lee SOdoi
10.3346/jkms.2010.25.2.313subject
Has Abstractpub_date
2010-02-01 00:00:00pages
313-6issue
2eissn
1011-8934issn
1598-6357journal_volume
25pub_type
杂志文章abstract::Chimerism in humans is a rare phenomenon often initially identified in the resolution of an ABO blood type discrepancy. We report a dispermic chimera who presented with mixed field in his B antigen typing that might have been mistaken for the B3 subtype. The propositus is a healthy Korean male blood donor. Neither his...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.3.553
更新日期:2007-06-01 00:00:00
abstract:Background:We described a novel multi-step retinal fundus image reading system for providing high-quality large data for machine learning algorithms, and assessed the grader variability in the large-scale dataset generated with this system. Methods:A 5-step retinal fundus image reading tool was developed that rates im...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
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abstract::To evaluate the predictive values of oxygenation index (OI), arterial-alveolar oxygen tension ratio (a/APO)2, and alveolar-arterial oxygen gradient ((A-a)DO2) for early recognition of responsiveness to high frequency oscillatory ventilation (HFOV) in very low birth weight infants with respiratory distress syndrome (RD...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2000.15.2.153
更新日期:2000-04-01 00:00:00
abstract::The incidence of specific intracranial parenchymal lesions of HIV-infected patients varies considerably between countries. In the Republic of Korea, the number of HIV-infected patients is increasing, but little is known regarding the spectrum of intracranial parenchymal lesions in these patients. The aim of the presen...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.7.1005
更新日期:2010-07-01 00:00:00
abstract::Tumor-to-tumor metastasis is rare. We report a case of metastatic renal cell carcinoma in meningioma. A 67-year-old woman presented a two-week history of motor dysphagia and decreased short-term memory. She had undergone a left radical nephrectomy for a renal cell carcinoma 7 years ago, and had not received any adjuva...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2000.15.5.593
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:This study described and analysed the features of powered mobility device (PMD)-related injuries and compared elderly and younger adult injuries. METHODS:Data from Korea Emergency Department-based Injury In-depth Surveillance (EDIIS) database involving eight emergency departments in 2011-2016 were analysed....
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e60
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abstract:BACKGROUND:Concern about bisphosphonate-associated subtrochanteric and femoral shaft (ST/FS) fractures has been raised. However, its real risk is still debatable, because there is no study to estimate risk and benefit of bisphosphonate. The objective of this study was to evaluate the risk of typical hip fractures and S...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e193
更新日期:2020-06-29 00:00:00
abstract::Neuronal migration disorders (NMDs) constitute the main pathologic substrate of medically intractable epilepsy in human. This study is designed to investigate the changes in expression of glutamate receptor subtypes on radiation-induced NMD in rats. The lesion was produced by intrauterine irradiation (240 cGy) on E17 ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2004.19.3.419
更新日期:2004-06-01 00:00:00
abstract::Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < or = 20 weeks of gestation and affects an estimated 1 of every 100 couples wishing to have children. However, it remains a poorly understood phenomenon. Recent reports observed a significant association between highly skewed X chromoso...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2004.19.2.258
更新日期:2004-04-01 00:00:00
abstract::p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a central role in tumor suppression. In this study we investigated p21 protein expression and mutation in gastric adenocarcinoma. A total of 76 primary gas...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1998.13.5.507
更新日期:1998-10-01 00:00:00
abstract::To determine the cytologic and histologic correlation of atypical glandular cells of undetermined significance (AGUS) in Papanicolaou smears, a cytology file from January 1998 to May 1999 was reviewed. Surgical pathology files were searched to determine which patients received subsequent biopsies. One hundred thirty-t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2001.16.2.214
更新日期:2001-04-01 00:00:00
abstract::The aim of this study was to develop a new simple method for measuring the vaporized volume and to evaluate the outcome of high-power potassium-titanyl-phosphate (KTP) photoselective laser vaporization. A total of 65 patients, with a mean age of 67.7 yr (range 53 to 85), were included in the primary analysis. The vapo...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.6.1187
更新日期:2009-12-01 00:00:00
abstract::The purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40-89 were recruited by the Korea National Institute of...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.9.1451
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Previous studies on the relationship between gastrointestinal (GI) cancer and cholecystectomy remain inconclusive. We aimed to evaluate this relationship, albeit particularly between cholecystectomy and gastric cancer or colorectal cancer (CRC), and the risk factors of cancer among individuals who have under...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e354
更新日期:2020-11-02 00:00:00
abstract::The data regarding risk factors for death during tuberculosis (TB) treatment are inconsistent, and few studies examined this issue in Korea. The purpose of this study was to evaluate baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea. A multicenter retrospective cohort ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章,多中心研究
doi:10.3346/jkms.2014.29.9.1226
更新日期:2014-09-01 00:00:00
abstract::We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not sh...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1991.6.2.165
更新日期:1991-06-01 00:00:00
abstract::Unintentional environmental exposure to toxicants is associated with an aggravated health status of the general population. Involuntary smoking (IS) exposure is one of the main routes to involuntary toxicants exposure. However, few studies have attempted to understand the environmental cadmium exposure by IS exposure ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.4.568
更新日期:2017-04-01 00:00:00
abstract::Transplantation studies about the clinical differences according to the type of donors are mostly conducted in western countries with rare reports from Asians. The aims of this study were to evaluate the clinical impacts of the type of donor, and the predictors of 1-year mortality in patients who underwent liver trans...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.8.1258
更新日期:2017-08-01 00:00:00
abstract::Lymphomatoid granulomatosis usually presents as a primary lung affliction with secondary metastatic spread to the central nervous system(CNS), and its initial manifestation purely as a CNS disease is rare. A 57-year-old man with histologically proven lymphomatoid granulomatosis of the brain as the sole manifestation o...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1991.6.3.255
更新日期:1991-09-01 00:00:00
abstract:Background:In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12-15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccinati...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2019.34.e83
更新日期:2019-03-07 00:00:00
abstract::In patients with colorectal cancer (CRC), the BRAF V600E mutation has been reported to be associated with several clinicopathological features and poor survival. However, the prognostic implications of BRAF V600E mutation and the associated clinicopathological characteristics in CRCs remain controversial. Therefore, w...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.1.38
更新日期:2017-01-01 00:00:00
abstract::Mutations in the calreticulin gene, CALR, have recently been discovered in subsets of patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF). We investigated Korean patients with ET and PMF to determine the prevalence, and clinical and laboratory correlations of CALR/JAK2/MPL mutations. Among 84 E...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2015.30.7.882
更新日期:2015-07-01 00:00:00
abstract::Protein C is the central component of a major anti-thrombotic regulatory system and individuals with hereditary protein C deficiency (PCD) tend to have an increased risk of thromboembolism. During the last several years, mutations causing PCD have been identified in Western countries and in Japanese. In the present st...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1998.13.2.186
更新日期:1998-04-01 00:00:00
abstract::Enterovirus 71 frequently involves the central nervous system and may present with a variety of neurologic manifestations. Here, we aimed to describe the clinical features, magnetic resonance imaging (MRI) findings, and cerebrospinal fluid (CSF) profiles of patients presenting with neurologic complications of enterovi...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2016.31.4.561
更新日期:2016-04-01 00:00:00
abstract::This study was to clarify whether Behcet's disease (BD) could be classified into the spondyloarthropathy (SpA) complex. It was undertaken on 58 patients with BD (BD group), 56 patients with SpA (SpA group), and 3 patients who concurrently satisfied the criteria for BD and SpA (BDSpA group). The clinical parameters and...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2002.17.4.524
更新日期:2002-08-01 00:00:00
abstract::Septic arthritis and gout are major diseases that should be suspected in patients with acute monoarthritis. These two diseases are clinically similar and often indistinguishable without the help of synovial fluid analysis. Recently, a novel diagnostic rule for gout without synovial fluid analysis was developed and sho...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2015.30.6.700
更新日期:2015-06-01 00:00:00
abstract::The pathogenesis of chronic cyclosporine A (CsA) nephrotoxicity has not been elucidated, but apoptosis is thought to play an important role in CsA induced tubular atrophy. Recently Fas-Fas ligand system mediated apoptosis has been frequently reported in many epithelial cells as well as in T lymphocytes. We investigate...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2001.16.5.603
更新日期:2001-10-01 00:00:00
abstract::Since the cancer has been the leading cause of deaths in Korea, estimation of the cancer deaths for the upcoming years in the population using the vital statistics is considered to be necessary. The aim of this study was to estimate the number and trends of cancer deaths in Korea. The expected numbers of cancer deaths...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2002.17.5.611
更新日期:2002-10-01 00:00:00
abstract::IMR is useful for assessing the microvascular dysfunction after primary percutaneous coronary intervention (PCI). It remains unknown whether index of microcirculatory resistance (IMR) reflects the functional outcome in patients with anterior myocardial infarction (AMI) with or without microvascular obstruction (MO).Th...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.9.1044
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify the characteristics of injuries of school-aged children transported via emergency medical services (EMS) that occurred in schools by comparing with injuries that occurred outside of school. METHODS:Data from the 119 EMS from 2012 to 2014 were analyzed. School and no...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2018.33.e73
更新日期:2018-03-05 00:00:00