当前位置： SCI文献检索 > JOURNAL OF KOREAN MEDICAL SCIENCE期刊下所有文献 > Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.

Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment.

Abstract：

Background:The renal function of individuals is one of the reasons for the variations in therapeutic response to various drugs. Patients with renal impairment are often exposed to drug toxicity, even with drugs that are usually eliminated by hepatic metabolism. Previous study has reported an increased plasma concentration of indoxyl sulfate and decreased plasma concentration of 4β-hydroxy (OH)-cholesterol in stable kidney transplant recipients, implicating indoxyl sulfate as a cytochrome P450 (CYP) inhibiting factor. In this study, we aimed to evaluate the impact of renal impairment severity-dependent accumulation of indoxyl sulfate on hepatic CYP3A activity using metabolic markers. Methods:Sixty-six subjects were enrolled in this study; based on estimated glomerular filtration rate (eGFR), they were classified as having mild, moderate, or severe renal impairment. The plasma concentration of indoxyl sulfate was quantified using liquid chromatography-mass spectrometry (LC-MS). Urinary and plasma markers (6β-OH-cortisol/cortisol, 6β-OH-cortisone/cortisone, 4β-OH-cholesterol) for hepatic CYP3A activity were quantified using gas chromatography-mass spectrometry (GC-MS). The total plasma concentration of cholesterol was measured using the enzymatic colorimetric assay to calculate the 4β-OH-cholesterol/cholesterol ratio. The correlation between variables was assessed using Pearson's correlation test. Results:There was a significant negative correlation between MDRD eGFR and indoxyl sulfate levels. The levels of urinary 6β-OH-cortisol/cortisol and 6β-OH-cortisone/cortisone as well as plasma 4β-OH-cholesterol and 4β-OH-cholesterol/cholesterol were not correlated with MDRD eGFR and the plasma concentration of indoxyl sulfate. Conclusion:Hepatic CYP3A activity may not be affected by renal impairment-induced accumulation of plasma indoxyl sulfate.

journal_name

J Korean Med Sci

journal_title

Journal of Korean medical science

authors

Kim AH,Yoon S,Lee Y,Lee J,Bae E,Lee H,Kim DK,Lee S,Yu KS,Jang IJ,Cho JY

doi

10.3346/jkms.2018.33.e298

subject

Has Abstract

pub_date

2018-10-31 00:00:00

pages

e298

issue

53

eissn

1011-8934

issn

1598-6357

journal_volume

33

pub_type

杂志文章

相关文献

JOURNAL OF KOREAN MEDICAL SCIENCE文献大全
  • What are the Barriers to Antenatal Care Utilization in Rufisque District, Senegal?: a Bottleneck Analysis.

    abstract：Background:This study aimed to analyze the barriers affecting the utilization of antenatal care (ANC) among Senegalese mothers. Methods:Health facility staffs were surveyed to examine the availability coverage of ANC (infrastructural capacity of health posts to handle maternal and newborn healthcare). A total of 113 w...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2019.34.e62

    authors： Kim KH,Choi JW,Oh J,Moon J,You S,Woo Y

    更新日期：2019-02-15 00:00:00

  • Abnormal morphological patterns of the left ventricular myocardium in the critical stenosis of the aortic valve and the intact ventricular septum.

    abstract：:The evaluation of prognostic factors in infants with critical stenosis of the aortic valve and intact ventricular septum is often misleading due to a complex interaction among lesions in the mitral and aortic valves, and the left ventricular myocardium. The clinical parameters on the left ventricular function, such as...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1997.12.1.49

    authors： Kim SH,Woo HO,Kim YM,Han JJ,Sohn SJ,Bae EJ,Lee YT,Oh MH,Yoo SJ,Seo JW

    更新日期：1997-02-01 00:00:00

  • Potential Association of Triglyceride Glucose Index with Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus Patients.

    abstract：:Cardiac autonomic neuropathy (CAN) is a common and most neglected complication of diabetes, estimated to be roughly 8% in recently diagnosed patients and greater than 50% in patients with chronic disease history. The insulin resistance (IR) itself is bidirectionally associated with increased risk of type 2 diabetes me...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2017.32.7.1131

    authors： Akbar M,Bhandari U,Habib A,Ahmad R

    更新日期：2017-07-01 00:00:00

  • Mortality of community-acquired pneumonia in Korea: assessed with the pneumonia severity index and the CURB-65 score.

    abstract：:The pneumonia severity index (PSI) and CURB-65 are widely used tools for the prediction of community-acquired pneumonia (CAP). This study was conducted to evaluate validation of severity scoring system including the PSI and CURB-65 scores of Korean CAP patients. In the prospective CAP cohort (participated in by 14 hos...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2013.28.9.1276

    authors： Kim HI,Kim SW,Chang HH,Cha SI,Lee JH,Ki HK,Cheong HS,Yoo KH,Ryu SY,Kwon KT,Lee BK,Choo EJ,Kim DJ,Kang CI,Chung DR,Peck KR,Song JH,Suh GY,Shim TS,Kim YK,Kim HY,Moon CS,Lee HK,Park SY,Oh JY,Jung SI,Park

    更新日期：2013-09-01 00:00:00

  • Predictors of Default from Treatment for Tuberculosis: a Single Center Case-Control Study in Korea.

    abstract：:Default from tuberculosis (TB) treatment could exacerbate the disease and result in the emergence of drug resistance. This study identified the risk factors for default from TB treatment in Korea. This single-center case-control study analyzed 46 default cases and 100 controls. Default was defined as interrupting trea...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2016.31.2.254

    authors： Park CK,Shin HJ,Kim YI,Lim SC,Yoon JS,Kim YS,Kim JC,Kwon YS

    更新日期：2016-02-01 00:00:00

  • Pulmonary complications after hematopoietic stem cell transplantation.

    abstract：:Despite advanced effective prophylaxes, pulmonary complications still occur in a high proportion of all hematopoietic stem cell recipients, accounting for considerable morbidity and mortality. The aim of our study was to describe the causes, incidences and mortality rates secondary to pulmonary complications and risk ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2006.21.3.406

    authors： Lim DH,Lee J,Lee HG,Park BB,Peck KR,Oh WS,Ji SH,Lee SH,Park JO,Kim K,Kim WS,Jung CW,Park YS,Im YH,Kang WK,Park K

    更新日期：2006-06-01 00:00:00

  • Experience of orthotopic liver transplantation in 11 patients with liver cirrhosis from Korea: medical factors affecting outcome.

    abstract：:Orthotopic liver transplantation (OLT) has evolved to become a standard treatment of choice for end-stage liver diseases. The present study was performed to evaluate the peri-operative medical factors affecting transplantation outcome and to determine if patients with type B viral cirrhosis were acceptable for OLT. A ...

    journal_title：Journal of Korean medical science

    pub_type： 临床试验,杂志文章

    doi：10.3346/jkms.1998.13.3.299

    authors： Choi JY,Park YM,Byun BH,Kim TY,Yoon SK,Chung KW,Sun HS,Park DH,Kim BS,Kim DG,Kim IC

    更新日期：1998-06-01 00:00:00

  • Necrotizing lymphadenitis--a clinico-pathologic study of 36 cases with immunohistochemical analysis.

    abstract：:Thirty-six cases of necrotizing lymphadenitis--including 33 cases of unknown etiology, 1 typhoid lymphadenopathy, and 2 cases of suspicious lupus lymphadenopathy--were clinico-pathologically reviewed and analyzed with immunostaining for s-100 and lysozyme. All cases histologically showed architectural effacement by pa...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1991.6.1.55

    authors： Cho KJ,Kim CW,Park SH,Lee SK

    更新日期：1991-03-01 00:00:00

  • Korean-specific parameter models for calculating the risk of Down syndrome in the second trimester of pregnancy.

    abstract：:The purpose of the current study was to propose a Korean-specific parameter set for calculating the risk of Down syndrome in the second trimester of pregnancy and to determine the screening performances of triple and quadruple tests in Korean women. Using the data on triple or quadruple screening from three hospitals ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2011.26.12.1619

    authors： Kwon JY,Park IY,Park YG,Lee Y,Lee G,Shin JC

    更新日期：2011-12-01 00:00:00

  • Clinicopathologic comparison of eroded polypoid hyperplasia and solitary rectal ulcer syndrome.

    abstract：:We experienced two unusual cases of tumor-like polypoid lesions involving the rectosigmoid colon. They could not be readily classified into any well known polypoid tumors of the rectosigmoid colon, but appeared to have some similarities to the previously documented "eroded polypoid hyperplasia (EPH)". A collective rev...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1994.9.4.319

    authors： Cho NH,Park CI,Ahn HJ

    更新日期：1994-08-01 00:00:00

  • Anastomosis of vessels less than 2 mm with the vascular clip system clip applier.

    abstract：:Sutures may cause endothelial trauma and occlusion. The vascular clip system (VCS) clip applier may minimize endothelial injury. Fourteen carotid arteries of nine adult rabbits were transected and re-anastomosed with either #7-0 polypropylene (Group I, n=8) or VCS clips (Group II, n=6). The animals were sacrificed at ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2001.16.3.303

    authors： Lee JW,Choo SJ,Oh JH,Lee I,Kwon YM,Lee YJ,Lee SK,Song H,Song MG

    更新日期：2001-06-01 00:00:00

  • Detection of sentinel lymph nodes in patients with early stage cervical cancer.

    abstract：:The purpose of this study was to determine the feasibility of identifying the sentinel lymph nodes (SNs) as well as to evaluate factors that might influence the SN detection rate in patients with cervical cancer of the uterus. Eighty nine patients underwent intracervical injection of 1% isosulfan blue dye at the time ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2007.22.1.105

    authors： Seong SJ,Park H,Yang KM,Kim TJ,Lim KT,Shim JU,Park CT,Lee KH

    更新日期：2007-02-01 00:00:00

  • The role of whole-body FDG PET/CT, Tc 99m MDP bone scintigraphy, and serum alkaline phosphatase in detecting bone metastasis in patients with newly diagnosed lung cancer.

    abstract：:Bone scan (BS) and serum alkaline phosphatase (ALP) concentration are used to detect bone metastasis in malignancy, although whole-body fluoro-D-glucose positron emission tomography computed tomography (FDG PET/CT) is being used increasingly. But BS is still used for the detection of metastatic bone lesion. So we comp...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2009.24.2.275

    authors： Min JW,Um SW,Yim JJ,Yoo CG,Han SK,Shim YS,Kim YW

    更新日期：2009-04-01 00:00:00

  • Application of Baveno Criteria and Modified Baveno Criteria with Shear-wave Elastography in Compensated Advanced Chronic Liver Disease.

    abstract：BACKGROUND:We aimed to validate Baveno VI and expanded Baveno VI criteria using two dimensional shear-wave elastography (2D-SWE) in compensated advanced chronic liver disease (cACLD) patients with alcohol as the main etiology. METHODS:Clinical data from 305 patients with cACLD who underwent a liver stiffness measureme...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2020.35.e249

    authors： Kang SH,Baik SK,Kim MY

    更新日期：2020-08-03 00:00:00

  • Differential pattern of perivascular type IV collagen deposits in phyllodes tumors of the breast.

    abstract：:Deposition of basement membrane extracellular matrix is influenced by adjacent tumor cells, and in some cases, the pattern of type IV collagen deposit is characteristic in malignant tumors. In this report, we analyzed the difference in type IV collagen deposition patterns between benign and malignant phyllodes tumors ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1992.7.4.360

    authors： Kim WH,Kim CW,Noh DY,Kim YI

    更新日期：1992-12-01 00:00:00

  • Eosinophilic gastroenteritis associated with food allergy and bronchial asthma.

    abstract：:In some patients, eosinophilic gastroenteritis(EG) occurs in those with food allergy. We experienced a non-atopic asthmatic who had an EG associated with food allergy to fish and eggs, and blood eosinophilia. A skin prick test and RAST to causative food allergens showed a negative result. A fiber-optic endoscopic biop...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1995.10.3.216

    authors： Park HS,Kim HS,Jang HJ

    更新日期：1995-06-01 00:00:00

  • Comparison of Baseline Characteristics between Community-based and Hospital-based Suicidal Ideators and Its Implications for Tailoring Strategies for Suicide Prevention: Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior.

    abstract：:In this cross-sectional study, we aimed to identify distinguishing factors between populations with suicidal ideation recruited from hospitals and communities to make an efficient allocation of limited anti-suicidal resources according to group differences. We analyzed the baseline data from 120 individuals in a commu...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2017.32.9.1522

    authors： Park CHK,Lee JW,Lee SY,Moon J,Shim SH,Paik JW,Kim SG,Cho SJ,Kim MH,Kim S,Park JH,You S,Jeon HJ,Ahn YM

    更新日期：2017-09-01 00:00:00

  • Prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea.

    abstract：:This study was aimed to evaluate the prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea. A total of 1,363 patients with atopic dermatitis, urticaria, enterocolitis syndrome, bronchial asthma or allergic rhinitis were recruited. First, we estimated the prevalence of sensitizati...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2003.18.4.473

    authors： Ahn KM,Han YS,Nam SY,Park HY,Shin MY,Lee SI

    更新日期：2003-08-01 00:00:00

  • Computerized quality control of radioimmunoassay in Korea.

    abstract：:Automated data processing and quality control of radioimmunoassays offer not only increased speed but also a more thorough and statistically rigorous analysis of results. An external quality assessment scheme for serum thyroxine, triiodothyronine and thyroid stimulating hormone (TSH) assays was performed in five nucle...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1988.3.3.117

    authors： Chung JK,Koong SS,Lee MH,Chung SK,Lee MC,Cho BY,Kim CY,Koh CS,Park SS

    更新日期：1988-09-01 00:00:00

  • The effect of body mass index on survival in advanced epithelial ovarian cancer.

    abstract：:Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2014.29.6.793

    authors： Bae HS,Hong JH,Ki KD,Song JY,Shin JW,Lee JM,Lee JK,Lee NW,Lee C,Lee KW,Kim YM

    更新日期：2014-06-01 00:00:00

  • A case of renal crisis in a Korean scleroderma patient with anti-RNA polymerase I and III antibodies.

    abstract：:Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum c...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2006.21.6.1121

    authors： Kang EH,Im CH,Kim SH,Chung JR,Lee EY,Kim DJ,Lee EB,Song YW

    更新日期：2006-12-01 00:00:00

  • Kind and estimated stocking amount of antidotes for initial treatment for acute poisoning at emergency medical centers in Korea.

    abstract：:Antidotes for toxicological emergencies can be life-saving. However, there is no nationwide estimation of the antidotes stocking amount in Korea. This study tried to estimate the quantities of stocking antidotes at emergency department (ED). An expert panel of clinical toxicologists made a list of 18 emergency antidot...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2014.29.11.1562

    authors： Sohn CH,Ryoo SM,Lim KS,Kim W,Lim H,Oh BJ

    更新日期：2014-11-01 00:00:00

  • PHEX gene mutations and genotype-phenotype analysis of Korean patients with hypophosphatemic rickets.

    abstract：:X-linked hypophosphatemic rickets (XLH) results from mutations in the PHEX gene. Mutational analysis of the PHEX gene in 15 unrelated Korean patients with hypophosphatemic rickets revealed eight mutations, including five novel mutations, in nine patients: two nonsense mutations, two missense mutations, one insertion, ...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2007.22.6.981

    authors： Song HR,Park JW,Cho DY,Yang JH,Yoon HR,Jung SC

    更新日期：2007-12-01 00:00:00

  • Characteristics of Children with Acute Carbon Monoxide Poisoning in Ankara: A Single Centre Experience.

    abstract：:The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient w...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2015.30.12.1836

    authors： Unsal Sac R,Taşar MA,Bostancı İ,Şimşek Y,Bilge Dallar Y

    更新日期：2015-12-01 00:00:00

  • Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.

    abstract：:The selective cyclooxygenase-2 (COX-2) and 5-lipoxygenase (LOX) inhibitors might inhibit prostaglandin synthesis and reduce proteinuria. The present study was designed to investigate the anti-proteinuric effects of nordihydroguaiaretic acid (NDGA) as compared with celecoxib in puromycin aminonucleoside (PAN) nephrosis...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2009.24.S1.S183

    authors： Lee DW,Kwak IS,Lee SB,Song SH,Seong EY,Chung HC,Yang BY,Lee MY,Sol MY

    更新日期：2009-01-01 00:00:00

  • Malignant lymphomas in Korea.

    abstract：:A retrospective histological study of 540 malignant lymphomas diagnosed at the Department of Pathology of the Seoul National University from 1976 through 1986 is presented. Malignant lymphoma is the 10th most common malignant tumor in Korea, comprising 3.07% of all malignancy during period of study. Among malignant ly...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.1987.2.4.231

    authors： Chi JG,Kim CW,Cho KJ,Lee SK

    更新日期：1987-12-01 00:00:00

  • The relationship between disc degeneration and morphologic changes in the intervertebral foramen of the cervical spine: a cadaveric MRI and CT study.

    abstract：:A cadaveric study was performed to investigate the relationship between disc degeneration and morphological changes in the intervertebral foramen of cervical spine, including the effect on the nerve root. Seven fresh frozen human cadavers were dissected from C1 to T1, preserving the ligaments, capsules, intervertebral...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2004.19.1.101

    authors： Sohn HM,You JW,Lee JY

    更新日期：2004-02-01 00:00:00

  • Comparison of Early and Late Tuberculosis Deaths in Korea.

    abstract：:The cause of death in patients with tuberculosis (TB) may differ according to the phase of anti-tuberculosis treatment. However, there are limited data regarding this issue in Korea. We compared the cause of death of TB patients who died during the early intensive and late continuation phase of treatment. Twenty (56%)...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2017.32.4.700

    authors： Lee J,Nam HW,Choi SH,Yoo SS,Lee SY,Cha SI,Park JY,Kim CH

    更新日期：2017-04-01 00:00:00

  • Effect of Institutional Case Volume on In-Hospital and Long-Term Mortality in Critically Ill Patients Requiring Mechanical Ventilation for 48 Hours or More.

    abstract：BACKGROUND:The purpose of this study was to evaluate whether institutional case volume affects clinical outcomes in patients receiving mechanical ventilation for 48 hours or more. METHODS:We conducted a nationwide retrospective cohort study using the database of Korean National Healthcare Insurance Service. Between Ja...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2019.34.e212

    authors： Lee H,Choi S,Jang EJ,Lee J,Kim D,Yoo S,Oh SY,Ryu HG

    更新日期：2019-09-02 00:00:00

  • Chronic Intussusception Caused by Diffuse Large B-Cell Lymphoma in a 6-Year-Old Girl Presenting with Abdominal Pain and Constipation for 2 Months.

    abstract：:The classical triad of abdominal pain, vomiting, and bloody stool is absent in chronic intussusception for more than 2 weeks. Here, we report a 6-year-old female with recurrent abdominal pain for 2 months. Ultrasonography of the abdomen revealed an ileocolic-type intussusception. The lesion accompanying the tight fibr...

    journal_title：Journal of Korean medical science

    pub_type： 杂志文章

    doi：10.3346/jkms.2016.31.2.321

    authors： Choi SH,Han SA,Won KY

    更新日期：2016-02-01 00:00:00