The effect of body mass index on survival in advanced epithelial ovarian cancer.

Abstract:

:Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.

journal_name

J Korean Med Sci

authors

Bae HS,Hong JH,Ki KD,Song JY,Shin JW,Lee JM,Lee JK,Lee NW,Lee C,Lee KW,Kim YM

doi

10.3346/jkms.2014.29.6.793

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

793-7

issue

6

eissn

1011-8934

issn

1598-6357

journal_volume

29

pub_type

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