Abstract:
:The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) cross-linked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), Delta EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (tau) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Choi SY,Chang HJ,Choi SI,Kim KI,Cho YS,Youn TJ,Chung WY,Chae IH,Choi DJ,Kim HS,Kim CH,Oh BH,Kim MHdoi
10.3346/jkms.2009.24.1.32subject
Has Abstractpub_date
2009-02-01 00:00:00pages
32-9issue
1eissn
1011-8934issn
1598-6357journal_volume
24pub_type
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