Abstract：
:A culture of the Leptospira species and the microscopic agglutination test (MAT) are considered as the reference standard for the diagnosis of leptospirosis, but both tests are imperfect for early diagnosis. We describe 4 patients diagnosed with leptospirosis using nested polymerase chain reaction (N-PCR) that targeted the 16S rRNA gene and the passive hemagglutination assay (PHA). In our 4 cases, Leptospira DNA in the urine, plasma, or cerebrospinal fluid (CSF), was detected by N-PCR in the early phase of leptospirosis, except in the sample from the buffy coat. Especially, case 3 showed that N-PCR with the urine and CSF was positive 8 days after symptom onset, but not for the plasma or buffy coat. We report 4 cases of leptospirosis that were diagnosed by N-PCR that targeted the 16S rRNA gene with urine, plasma, or CSF, but not the buffy coat. Three were cured by doxycycline but the case 4 was fatal. Detection of Leptospira DNA by PCR from the urine and CSF, in addition to plasma, may be helpful to confirm the diagnosis.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Na YS,Kim HL,Kim CM,Yun NR,Kim DMdoi
10.3346/jkms.2020.35.e301subject
Has Abstractpub_date
2020-09-14 00:00:00pages
e301issue
36eissn
1011-8934issn
1598-6357pii
35.e301journal_volume
35pub_type
abstract：:The aim of our study was to evaluate the utility and diagnostic accuracy of the ossification grade of medial clavicular epiphysis on chest radiographs for identifying Korean adolescents and young adults under the age of majority. Overall, 1,151 patients (age, 16-30) without any systemic disease and who underwent chest...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2016.31.10.1538
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abstract：:Aim of this study was to compare the outcomes of transplantation by donor source and to help select the best alternative donor in children with leukemia. Donor sources included matched related donor (MRD, n = 35), allele-matched unrelated donor (M-UD, n = 10) or -mismatched (MM)-UD (n = 13) or unrelated umbilical cord...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2011.26.12.1548
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abstract：:To develop an objective and scientific method to evaluate the brain injured and brain diseased persons with motor dysfunction, American Medical Association's Guides to the Evaluation of Permanent Impairment was used as an exemplar. After the motor dysfunction due to brain injury or brain disease was confirmed, active ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,实务指引
doi：10.3346/jkms.2009.24.S2.S247
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abstract：:IMR is useful for assessing the microvascular dysfunction after primary percutaneous coronary intervention (PCI). It remains unknown whether index of microcirculatory resistance (IMR) reflects the functional outcome in patients with anterior myocardial infarction (AMI) with or without microvascular obstruction (MO).Th...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.9.1044
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abstract：:Pediatric liver transplantation is the standard of care for treatment of liver failure in children. The aim of this study was to identify the characteristics of pediatric liver transplantation in centers located in Korea and determine factors that influence outcomes. This retrospective study was performed using data f...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2013.28.1.42
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abstract：:Our study aimed to examine the knowledge and attitude of nursing personnel toward depression in general hospitals of Korea. A total of 851 nursing personnel enrolled at four university-affiliated general hospitals completed self-report questionnaires. Chi-square tests were used to compare the knowledge and attitude of...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2015.30.7.953
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doi：10.3346/jkms.2020.35.e372
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.1.88
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abstract：:Cutaneous nocardiosis, which usually manifests in the form of pustules, abscesses, or subcutaneous nodules, is occasionally found in immunocompromised patients. A 59-yr-old Korean man with myasthenia gravis and thymoma developed nodular skin lesions on his trunk. Histopathologically, abscess formation with a dense inf...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2002.17.2.279
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2008.23.3.551
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pub_type： 杂志文章
doi：10.3346/jkms.2020.35.e91
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abstract：:Although cervical epidural abscess is rare, it should be strongly suspected in any patient with unexplainable neck pain and fever, especially when the patient has a predisposing factor for this infectious process. The authors report a case of cervical epidural abscess in a 39-yr-old man with an aorto-duodenal fistula,...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2003.18.1.116
更新日期：2003-02-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2016.31.12.1922
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.3.278
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:On February 21, 2020, 2 coronavirus disease 2019 (COVID-19) cases in pilgrim travelers from Korea to Israel were identified. We investigated the source of infection, clinical features of COVID-19, and transmission potential of presymptomatic and asymptomatic cases. METHODS:All 39 pilgrim travelers were aggr...
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pub_type： 杂志文章
doi：10.3346/jkms.2020.35.e424
更新日期：2020-12-14 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2017.32.12.2051
更新日期：2017-12-01 00:00:00
abstract：:Deposition of basement membrane extracellular matrix is influenced by adjacent tumor cells, and in some cases, the pattern of type IV collagen deposit is characteristic in malignant tumors. In this report, we analyzed the difference in type IV collagen deposition patterns between benign and malignant phyllodes tumors ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1992.7.4.360
更新日期：1992-12-01 00:00:00
abstract：:The Rejuran® is a new filler product made from purified polynucleotides. Here we present data from an animal study and a clinical trial to examine the durability, efficacy and safety of the Rejuran® on crow's feet. For the animal study, 25 mice were divided into three groups: Group 1 received phosphate buffered saline...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,随机对照试验,收录出版
doi：10.3346/jkms.2014.29.S3.S201
更新日期：2014-11-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.4.631
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.1.167
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abstract：:Size selection of the laryngeal mask airway (LMA) Classic based on actual body weight remains a common practice. However, ideal body weight might allow for a better size selection in obese patients. The purpose of our study was to compare the utility of ideal body weight and actual body weight when choosing the approp...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2014.29.7.973
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2005.20.6.1046
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abstract：:Lyme disease is a vector-borne infection, primarily transmitted by Ixodes ticks, and caused by Borrelia burgdorferi. It has a wide distribution in the northern hemisphere. In Korea, however, only one human case has been reported, although B. burgdorferi was isolated from the vector tick I. persulcatus in the region. A...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1999.14.1.85
更新日期：1999-02-01 00:00:00
abstract：:We aimed to investigate the clinical value of persistent but downgraded vesicoureteral reflux (VUR) after dextranomer/hyaluronic acid (Dx/HA) injection in children. The medical records of 128 children (195 ureters) who underwent Dx/HA injections for VUR were reviewed. The incidences of pre- and post-operative febrile ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.7.1060
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abstract：:An experiment was designed to investigate the reaction mechanism of AP (apurinic or apyrimidinic) DNA endonucleases (APcI, APcII, APcIII) purified from rat liver chromatin. Sulfhydryl compounds (2-mercaptoethanol, dithiothreitol) brought about optimal activities of AP DNA endonucleases and N-ethylmaleimide or HgCl2 in...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1990.5.3.137
更新日期：1990-09-01 00:00:00
abstract：Background:Although preterm delivery is the most common cause of infant morbidity and mortality, an obvious cause cannot be found in most cases. Preterm delivery is known to be the most important risk factor for preterm birth in a subsequent pregnancy. We aimed to evaluate the recurrence rate of premature births for su...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e170
更新日期：2018-05-11 00:00:00
abstract：:The endothelial nitric oxide synthase (eNOS) gene plays an important role in several biological functions. Polymorphisms of the eNOS gene have been associated with cancer. It has been suggested that the VNTR 4 a/b polymorphism may affect the expression of eNOS and contributes to tumor promotion in the mammary gland. W...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.11.1587
更新日期：2013-11-01 00:00:00
abstract：:The reasons for the viral persistence of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Several matrix metalloproteinases (MMPs) can regulate an inflammatory response. The aim of this study was to assess the effects of the single nucleotide polymorphisms (SNPs) of MMP-3...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2008.23.1.61
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