Abstract：
:The cloning and sequencing of thyroid-stimulating hormone (TSH) receptor (TSHR), combined with advances in molecular techniques, have facilitated the understanding of the interaction of the TSHR antibodies (TSHRAbs) with the TSHR at the molecular level and have allowed the delineation of their clinical role. TSHRAbs in vivo are functionally heterogeneous; the stimulating TSHRAbs cause hyperthyroidism and diffuse goiter in patients with Graves' disease, whereas, the blocking TSHRAbs cause hypothyroidism in some patients with autoimmune hypothyroidism and are the cause of transient neonatal hypothyroidism. Measuring TSHRAbs has potential clinical implications in differential diagnosis of Graves' disease, predicting the outcome of Graves' disease after antithyroid drug treatment, and predicting the fetal/neonatal hyperthyroidism or neonatal hypothyroidism. The existence of epitope heterogeneity in a patient, i.e., of stimulating TSHRAbs with epitopes other than on the N-terminal region of the extracellular domain, is significantly associated with favorable long-term clinical response to antithyroid drug treatment. Measuring these subtypes for thyroid-stimulating antibody (TSAb) has potential clinical implications, for example, in predicting responsiveness to treatment in untreated patients with Graves' disease.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Cho BYdoi
10.3346/jkms.2002.17.3.293keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
293-301issue
3eissn
1011-8934issn
1598-6357pii
200206293journal_volume
17pub_type
杂志文章,评审abstract：:A 32-yr-old man developed progressive exertional dyspnea 4 yr after blunt chest trauma due to an automobile accident. Two-dimensional echocardiography and computed-tomographic coronary angiography demonstrated a large pseudoaneurysm of the left ventricle and severe tricuspid regurgitation. The patient underwent succes...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.4.443
更新日期：2012-04-01 00:00:00
abstract：:Several factors can affect the perioperative immune function. We evaluated the effect of propofol and desflurane anesthesia on the surgery-induced immune perturbation in patients undergoing breast cancer surgery. The patients were randomly assigned to receive propofol (n = 20) or desflurane (n = 20) anesthesia. The to...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,随机对照试验
doi：10.3346/jkms.2015.30.10.1503
更新日期：2015-10-01 00:00:00
abstract：:Using the Korean public health insurance database, we analyzed patients diagnosed as benign prostatic hyperplasia (BPH) from 2004 to 2008. Age and year-specific amount and seasonal variation of hospital visits (HV), duration of treatment (DT), the total and per capita amount of insurance payment (TAIP, PCIP) were eval...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.2.180
更新日期：2015-02-01 00:00:00
abstract：:Recently reports on toxocariasis are increasing by serodiagnosis in Korea. A previously healthy 17-yr-old boy complained of headache, fever, dyspnea, and anorexia. He showed symptoms and signs of eosinophilic meningitis with involvement of the lungs and liver. Specific IgG antibody to Toxocara canis larval antigen was...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.9.1105
更新日期：2012-09-01 00:00:00
abstract：:Evidence suggests that multiple molecular events, including alteration of cell cycle regulators are involved in the development and progression of gastric carcinoma. Recently, it has been reported that the expression of p21 and p27, integrating the effects of one or more cell cycle regulators, consequently, acting as ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1998.13.4.369
更新日期：1998-08-01 00:00:00
abstract：:Phospholipase C (PLC) and related enzymes in signal transduction system are closely linked to cellular damage in ischemic encephalopathy. This study was undertaken to elucidate the time sequential changes of PLC isoenzymes (beta and gamma) in vulnerable areas of hippocampus in global ischemia and infarcted area in foc...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1996.11.1.44
更新日期：1996-02-01 00:00:00
abstract：:This observational study aimed at evaluating recent superwarfarin intoxication of Korean patients. Ten patients were diagnosed as or highly suspicious for superwarfarin intoxication. Case report forms described by attending hematologists of the patients were collected and analyzed. Bleeding symptoms were varied among ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.12.1754
更新日期：2010-12-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIG) is being increasingly used to treat numerous immune-mediated diseases. However, there is a paucity of knowledge on the specific mode of action of IVIG in vivo. In this study, the in vitro effects of IVIG on peripheral blood mononuclear cell (PBMC) proliferation using phytohemagglutini...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2001.16.5.544
更新日期：2001-10-01 00:00:00
abstract：:It has been reported that the particulate matter under 10 microm (PM10) has deleterious effects on respiratory health. The purpose of this study was to assess the influence of PM10 upon normal children's lung function. The subjects were 368 middle school students in two areas of Incheon Metropolitan City. One (Incheon...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2005.20.1.42
更新日期：2005-02-01 00:00:00
abstract：:The purpose of this study was to explore the role of epithelial-mesenchymal transition in the pathogenesis of hepatolithiasis. Thirty-one patients with primary hepatolithiasis were enrolled in this study. Expressions of E-cadherin, alpha-catenin, alpha-SMA, vimentin, S100A4, TGF-beta1 and P-smad2/3 in hepatolithiasis ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.7.1066
更新日期：2010-07-01 00:00:00
abstract：:Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate ...
journal_title：Journal of Korean medical science
pub_type： 临床试验,杂志文章
doi：10.3346/jkms.2014.29.8.1102
更新日期：2014-08-01 00:00:00
abstract：:When access to a major duodenal papilla or endoscopic retrograde cholangiopancreatography has failed, percutaneous transhepatic cholangioscopic lithotripsy (PTCS-L) may be useful for removing common bile duct (CBD) stones. However, the feasibility and usefulness of percutaneous transhepatic papillary large-balloon dil...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.3.278
更新日期：2015-03-01 00:00:00
abstract：:Transjugular intrahepatic portosystemic shunt (TIPSS) is a promising method of treatment for gastric or esophageal variceal bleeding. This study was performed to determine the prognostic factors contributing to the survival of patients after TIPSS for gastric or esophageal variceal bleeding. One hundred and fifty-five...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2002.17.6.772
更新日期：2002-12-01 00:00:00
abstract：:Low quality clinical trials have a possibility to have errors in the process of deriving the results and therefore distort the study. Quality assessment of clinical trial is necessary in order to prevent any clinical application erroneous results is important. Randomized controlled trial (RCT) is a design for evaluate...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2012.27.9.973
更新日期：2012-09-01 00:00:00
abstract：:To investigate association between breast cancer risk and nutrients intake in Korean women, a case-control study was carried out, at Seoul, Korea. Incident cases (n=224) were identified through the cancer biopsy between February 1999 and December 2000 at two University hospitals in Seoul. Hospital-based controls (n=25...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2003.18.4.534
更新日期：2003-08-01 00:00:00
abstract：:Writing a good quality scientific article takes experience and skill. I propose 'Ten Tips' that may help to improve the quality of manuscripts for scholarly journals. It is advisable to draft first version of manuscript and revise it repeatedly for consistency and accuracy of the writing. During the drafting and revis...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2014.29.8.1035
更新日期：2014-08-01 00:00:00
abstract：:This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 microg/kg of GH once daily fo...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2009.24.4.729
更新日期：2009-08-01 00:00:00
abstract：:To develop an objective and scientific method to evaluate the brain injured and brain diseased persons with motor dysfunction, American Medical Association's Guides to the Evaluation of Permanent Impairment was used as an exemplar. After the motor dysfunction due to brain injury or brain disease was confirmed, active ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,实务指引
doi：10.3346/jkms.2009.24.S2.S247
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:We aimed to evaluate the feasibility of trauma-focused group therapy in adolescents exposed to traumatic events in Korea. METHODS:We recruited 22 adolescents (mean age, 16 years; standard deviation, 1.43; range, 13-18 years). Children in Disaster: Evaluation and Recovery (CIDER) V1.0 is a trauma-focused gro...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2020.35.e240
更新日期：2020-07-27 00:00:00
abstract：:This study was designed to identify the causes of the development of carpal tunnel syndrome (CTS) associated with end stage kidney disease (ESKD). A total of 112 patients with ESKD, 64 on hemodialysis (HD) and 48 on peritoneal dialysis (PD), were enrolled. The duration of ESKD and dialysis, the site of the arterioveno...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2011.26.9.1227
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Working status is identified as a major risk factor of poor breastfeeding practices among workers. This study aimed to evaluate the knowledge, attitude, and factors associated with breastfeeding practice among white-collar and blue-collar workers in Indonesia. METHODS:A cross-sectional study was performed i...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2019.34.e284
更新日期：2019-11-25 00:00:00
abstract：Background:Although preterm delivery is the most common cause of infant morbidity and mortality, an obvious cause cannot be found in most cases. Preterm delivery is known to be the most important risk factor for preterm birth in a subsequent pregnancy. We aimed to evaluate the recurrence rate of premature births for su...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e170
更新日期：2018-05-11 00:00:00
abstract：:Septic arthritis and gout are major diseases that should be suspected in patients with acute monoarthritis. These two diseases are clinically similar and often indistinguishable without the help of synovial fluid analysis. Recently, a novel diagnostic rule for gout without synovial fluid analysis was developed and sho...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.6.700
更新日期：2015-06-01 00:00:00
abstract：Background:Many studies have tried to develop predictors for return-to-work (RTW). However, since complex factors have been demonstrated to predict RTW, it is difficult to use them practically. This study investigated whether factors used in previous studies could predict whether an individual had returned to his/her o...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e144
更新日期：2018-04-25 00:00:00
abstract：BACKGROUND:To investigate the clinical and microbiological features of febrile patients with upper urinary tract calculi and factors that affect empirical antibiotic resistance. METHODS:A retrospective analysis was performed on 203 febrile patients hospitalized between January 2011 and December 2016 with antibiotic tr...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2021.36.e3
更新日期：2021-01-04 00:00:00
abstract：:We investigated the clinical presentations, diagnostic and therapeutic modalities, and prognosis from follow-up of infants with apparent life-threatening events (ALTE). In addition, the relationship between the clinical characteristics of patients and significant intervention scores was analyzed. We enrolled patients ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.6.763
更新日期：2015-06-01 00:00:00
abstract：Background:We aimed to estimate whether elevated levels of complement C3a and C5a in amniotic fluid (AF) are independently associated with increased risks of intra-amniotic infection and/or inflammation (IAI) and spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (≤ 25 mm). Meth...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e220
更新日期：2018-07-05 00:00:00
abstract：:Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for ...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2014.29.6.793
更新日期：2014-06-01 00:00:00
abstract：:Increased expression of glucose transporter1 (GLUT1) has been reported in many human cancers. We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. RT-PCR and immunostaining were used to analyze GLUT1 expression in gastric cancer. RT-PCR showed GLUT1 expressi...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2000.15.4.420
更新日期：2000-08-01 00:00:00
abstract：:West Nile encephalitis was first identified in 1937, but until now, it was never diagnosed in Korea. A 58-yr-old Korean man was admitted with headache and cognitive dysfunction. The patient had been on a business trip in Guinea. Cerebrospinal fluid (CSF) showed pleocytosis. The patient complained of both leg weakness,...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2015.30.3.343
更新日期：2015-03-01 00:00:00
