Epithelial-mesenchymal transitions of bile duct epithelial cells in primary hepatolithiasis.

Abstract:

:The purpose of this study was to explore the role of epithelial-mesenchymal transition in the pathogenesis of hepatolithiasis. Thirty-one patients with primary hepatolithiasis were enrolled in this study. Expressions of E-cadherin, alpha-catenin, alpha-SMA, vimentin, S100A4, TGF-beta1 and P-smad2/3 in hepatolithiasis bile duct epithelial cells were examined by immunohistochemistry staining. The results showed that the expressions of the epithelial markers E-cadherin and alpha-catenin were frequently lost in hepatolithiasis (32.3% and 25.9% of cases, respectively), while the mesenchymal markers vimentin, alpha-SMA and S100A4 were found to be present in hepatolithiasis (35.5%, 29.0%, and 32.3% of cases, respectively). The increased mesenchymal marker expression was correlated with decreased epithelial marker expression. The expressions of TGF-beta1 and P-smad2/3 in hepatolithiasis were correlated with the expression of S100A4. These data indicate that TGF-beta1-mediated epithelial-mesenchymal transition might be involved in the formation of hepatolithiasis.

journal_name

J Korean Med Sci

authors

Zhao L,Yang R,Cheng L,Wang M,Jiang Y,Wang S

doi

10.3346/jkms.2010.25.7.1066

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1066-70

issue

7

eissn

1011-8934

issn

1598-6357

journal_volume

25

pub_type

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