Comparative study of the effects of different growth hormone doses on growth and spatial performance of hypophysectomized rats.

Abstract:

:This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 microg/kg of GH once daily for 9 days; group 2, administered 200 microg/kg of GH twice daily; and group 3, administered saline daily. Somatic growth was evaluated by measurement of body weight daily and of the width of the proximal tibial growth plate of the HYPOX rats. Cognitive function was evaluated using the Morris water maze (MWM) test. The results indicated that GH replacement therapy in HYPOX rats promoted an increase in the body weight and the width of the tibial growth plate in a dose-dependent manner. On the third day of the MWM test, the escape latency in the GH-treated groups 1 and 2 was significantly shorter than that in the control rats (P<0.001 and P=0.032, respectively), suggesting that rhGH improved spatial memory acquisition in the MWM test. Therefore it is concluded that rhGH replacement therapy in HYPOX rats stimulates an increase in somatic growth in a dose-dependent manner and also has beneficial effects on cognitive functions.

journal_name

J Korean Med Sci

authors

Kwak MJ,Park HJ,Nam MH,Kwon OS,Park SY,Lee SY,Kim MJ,Kim SJ,Paik KH,Jin DK

doi

10.3346/jkms.2009.24.4.729

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

729-36

issue

4

eissn

1011-8934

issn

1598-6357

journal_volume

24

pub_type

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