Abstract:
:This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 microg/kg of GH once daily for 9 days; group 2, administered 200 microg/kg of GH twice daily; and group 3, administered saline daily. Somatic growth was evaluated by measurement of body weight daily and of the width of the proximal tibial growth plate of the HYPOX rats. Cognitive function was evaluated using the Morris water maze (MWM) test. The results indicated that GH replacement therapy in HYPOX rats promoted an increase in the body weight and the width of the tibial growth plate in a dose-dependent manner. On the third day of the MWM test, the escape latency in the GH-treated groups 1 and 2 was significantly shorter than that in the control rats (P<0.001 and P=0.032, respectively), suggesting that rhGH improved spatial memory acquisition in the MWM test. Therefore it is concluded that rhGH replacement therapy in HYPOX rats stimulates an increase in somatic growth in a dose-dependent manner and also has beneficial effects on cognitive functions.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kwak MJ,Park HJ,Nam MH,Kwon OS,Park SY,Lee SY,Kim MJ,Kim SJ,Paik KH,Jin DKdoi
10.3346/jkms.2009.24.4.729subject
Has Abstractpub_date
2009-08-01 00:00:00pages
729-36issue
4eissn
1011-8934issn
1598-6357journal_volume
24pub_type
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