Abstract:
:The purpose of this study was to determine the clinical significance of nodal micrometastasis detected by immunohistochemistry in patients that had undergone curative surgery for pancreatic cancer. Between 2005 and 2006, a total of 208 lymph nodes from 48 consecutive patients with pancreatic cancer that had undergone curative resection were immunostained with monoclonal antibody against pan-ck and CK-19. Micrometastasis was defined as metastasis missed by a routine H&E examination but detected during an immunohistochemical evaluation. Relations between immunohistochemical results and clinical and pathologic features and patient survival were examined. Nodal micrometastases were detected in 5 (29.4%) patients of 17 pN0 patients. Nodal micrometastasis was found to be related to tumor relapse (P = 0.043). Twelve patients without overt nodal metastasis and micrometastasis had better prognosis than 5 patients with only nodal micrometastasis (median survival; 35.9 vs 8.6 months, P < 0.001). The Cox proportional hazard model identified nodal micrometastasis as significant prognostic factors. Although the number of patients with micrometastasis was so small and further study would be needed, our study suggests that the lymph node micrometastasis could be the predictor of worse survival and might indicate aggressive tumor biology among patients undergoing curative resection for pancreas cancer.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Lee SE,Jang JY,Kim MA,Kim SWdoi
10.3346/jkms.2011.26.7.881subject
Has Abstractpub_date
2011-07-01 00:00:00pages
881-5issue
7eissn
1011-8934issn
1598-6357journal_volume
26pub_type
杂志文章abstract::This study was designed to examine the effects of recombinant human growth hormone replacement on somatic growth and cognitive function in hypophysectomized (HYPOX) female Sprague-Dawley rats. Rats (5 per group) were randomized by weight to 3 experimental groups: group 1, administered 200 microg/kg of GH once daily fo...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.4.729
更新日期:2009-08-01 00:00:00
abstract::Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect the deletions of putative tumor suppressor gene loci, chromosome 10, 13q(retinoblastoma gene, Rb), 17p, an...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1995.10.6.442
更新日期:1995-12-01 00:00:00
abstract::Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated during the progression of cancer. However, to date, there is very limited data on the clinical significance of maspin expres...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2006.21.2.309
更新日期:2006-04-01 00:00:00
abstract::Dermatomyositis (DM) is an uncommon inflammatory myopathy with characteristic rash accompanying, or more often preceding, muscle weakness. There is a well-recognized association between DM and several cancers, such as ovarian cancer, breast cancer, melanoma, colon cancer, and non-Hodgkin lymphoma. We report the first ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.S.S174
更新日期:2007-09-01 00:00:00
abstract::The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in elderly asthmatic patients. This was a prospective, multicenter, real-life study for 6 months with stepwis...
journal_title:Journal of Korean medical science
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3346/jkms.2015.30.8.1042
更新日期:2015-08-01 00:00:00
abstract::Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delica...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1995.10.5.342
更新日期:1995-10-01 00:00:00
abstract::Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of th...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1993.8.1.24
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:On February 2, 2017, the surgical team of ten board-certified hand specialists of W Hospital in Korea successfully performed the nation's first hand transplantation at Yeungnam University Medical Center (YUMC). This paper reports on the legal, financial, and cultural hurdles that were overcome to open the wa...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2021.36.e6
更新日期:2021-01-11 00:00:00
abstract::This study investigated the production of stromal cell-derived factor-1 (SDF-1) and the expression of CXCR4 in human bone marrow endothelial cells (BMECs). Human BMEC cell line BMEC-1 cells expressed SDF-1 mRNA, and conditioned medium induced chemoattraction of CD34+ cells. Migration was not inhibited by pretreating t...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2003.18.5.679
更新日期:2003-10-01 00:00:00
abstract::Seasonal influenza is a significant cause of morbidity and mortality of children in Korea. However, few data are available on parental perception and action toward childhood influenza. This study aimed to characterize parental perception and patterns of action in response to influenza and influenza-like illnesses (ILI...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.2.204
更新日期:2017-02-01 00:00:00
abstract::Asynchronous bilateral torsion of the spermatic cord in the newborn is extremely rare. We report such a case in a 4-day-old boy with subsequent operative discovery of prior in utero torsion of the contralateral spermatic cord. The diagnosis was made by physical examination, transillumination test, color Doppler ultras...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2002.17.5.712
更新日期:2002-10-01 00:00:00
abstract::The objective of this study was to investigate the national trends in rotator cuff surgery in Korea and analyze hospital type-specific trends. We analyzed a nationwide database acquired from the Korean Health Insurance Review and Assessment Service (HIRA) from 2007 to 2015. International Classification of Diseases, 10...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2017.32.2.357
更新日期:2017-02-01 00:00:00
abstract::NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this is associated with target-organ damage. Rats were infused with aldosterone (0.75 microg/hr/day) for 6...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2008.23.6.1039
更新日期:2008-12-01 00:00:00
abstract::A 17-yr-old young woman was referred to our hospital with a 2-yr history of claudication of the lower extremities and severe arterial hypertension. Physical examination revealed significantly different blood pressures between both arms (160/92 and 180/95 mmHg) and legs (92/61 and 82/57 mmHg). The hematological and bio...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2008.23.3.551
更新日期:2008-06-01 00:00:00
abstract::Bronchoplastic lobectomy is a lung-saving procedure indicated for central tumors, for which the alternative is pneumonectomy. We compared operative mortality and complications between bronchoplastic lobectomy and pneumonectomy in lung cancer patients. From March 1993 through December 2005, 1,461 patients were surgical...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2007.22.1.43
更新日期:2007-02-01 00:00:00
abstract::Central obesity has been reported as a risk for atherosclerosis and metabolic syndrome. The influence of central obesity on diurnal blood pressure (BP) has not been established. In this study, we investigated the influence of central obesity on the circadian parameters of BP by 24 hr ambulatory BP monitoring. Total 1,...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2013.28.10.1461
更新日期:2013-10-01 00:00:00
abstract::A case of Cushing's syndrome due to bilateral pigmented nodular adrenal disease in a 35-year-old male is presented. The adrenals showed multiple, black, variable sized nodules. Histologically the cells contained lipofuscin and either had a clear cytoplasm or an eosinophilic cytoplasm with a prominent nucleus. Lymphocy...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1994.9.6.450
更新日期:1994-12-01 00:00:00
abstract::A 42-year-old female diagnosed with tuberous sclerosis was found to have multiple polyps in the fundus of stomach. On histologic examination, the lesions were hamartomatous polyps. In tuberous sclerosis, many lesions occur in multiple organs and there are several reports about the frequent association of hamartomatous...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2000.15.4.467
更新日期:2000-08-01 00:00:00
abstract::Intravascular ultrasound (IVUS) imaging was performed to assess the coronary wall morphology in detail at 22 months after the onset of Kawasaki disease in a girl who had developed coronary aneurysms at 4 yr of age. The sites of persistent aneurysms demonstrated a dilated lumen with a marked symmetrical or asymmetrical...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2001.16.5.661
更新日期:2001-10-01 00:00:00
abstract::Fibrocartilaginous dysplasia (FCD) has occasionally led to a misdiagnosis and wrong decision which can significantly alter the outcome of the patients. A 9-yr-old boy presented with pain on his left distal thigh for 6 months without any trauma history. Initial radiographs showed moth eaten both osteolytic and osteoscl...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2013.28.4.631
更新日期:2013-04-01 00:00:00
abstract::The incidence of specific intracranial parenchymal lesions of HIV-infected patients varies considerably between countries. In the Republic of Korea, the number of HIV-infected patients is increasing, but little is known regarding the spectrum of intracranial parenchymal lesions in these patients. The aim of the presen...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.7.1005
更新日期:2010-07-01 00:00:00
abstract::We aimed to elucidate whether the eNOS T-786C mutant allele is implicated in subarachnoid hemorrhage (SAH) susceptibility or vasospasm after SAH, and whether the mutant allele is differentially expressed in those with small and large ruptured aneurysms in Korean population. 136 consecutive patients diagnosed with aneu...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2006.21.5.922
更新日期:2006-10-01 00:00:00
abstract::Despite the increasing use of the rectal balloon in prostate cancer radiotherapy, many issues still remain to be verified objectively including its positional reproducibility and relevance to treatment morbidity. We have developed a custom rectal balloon that has a scale indicating the depth of insertion and dilates s...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.5.894
更新日期:2009-10-01 00:00:00
abstract::Human metapneumovirus (HMPV) shares clinical and epidemiological characteristics with well-known respiratory syncytial virus (RSV). The aim of this study was to investigate the clinical and epidemiological differences between HMPV- and RSV-induced wheezing illnesses. A total of 1,008 nasopharyngeal aspirate specimens ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.3.342
更新日期:2010-03-01 00:00:00
abstract::Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast carcinomas and asse...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2009.24.1.97
更新日期:2009-02-01 00:00:00
abstract::The purpose of this study was to investigate the differences in subjective acute effects of alcohol and naltrexone among those who prefer spicy food to varying degrees. Acute biphasic alcohol effects scale (BAES), visual analogue scale for craving (VAS-C), blood alcohol concentration (BAC) and food preference scale we...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2014.29.5.714
更新日期:2014-05-01 00:00:00
abstract::To better understand the anatomic location of scalp nerves involved in various neurosurgical procedures, including awake surgery and neuropathic pain control, a total of 30 anterolateral scalp cutaneous nerves were examined in Korean adult cadavers. The dissection was performed from the distal to the proximal aspects ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.4.517
更新日期:2010-04-01 00:00:00
abstract::Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by CYP7B1 mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of ...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2018.33.e324
更新日期:2018-11-22 00:00:00
abstract::Size selection of the laryngeal mask airway (LMA) Classic based on actual body weight remains a common practice. However, ideal body weight might allow for a better size selection in obese patients. The purpose of our study was to compare the utility of ideal body weight and actual body weight when choosing the approp...
journal_title:Journal of Korean medical science
pub_type: 杂志文章,随机对照试验
doi:10.3346/jkms.2015.30.8.1197
更新日期:2015-08-01 00:00:00
abstract::Transverse myelitis (TM) extending from midbrain to the entire spinal cord accompanied by internuclear ophthalmoplegia is extremely rare but cause serious central nervous system complications in patients with systemic lupus erythematosus. We report a case of a 28-yr-old woman with TM extending from the midbrain to the...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2005.20.6.1085
更新日期:2005-12-01 00:00:00