Abstract:
:Although the incidence of bleeding complications during extracorporeal membrane oxygenator (ECMO) support has decreased in various trials, bleeding is still the most fatal complication. We investigated the ideal dosage and efficacy of nafamostat mesilate for use with ECMO in patients with acute cardiac or respiratory failure. We assessed 73 consecutive patients who received ECMO due to acute cardiac or respiratory failure between January 2006 and December 2009. To evaluate the efficacy of nafamostat mesilate, we divided the patients into 2 groups according to the anticoagulants used during ECMO support. All patients of nafamostat mesilate group were male with a mean age of 49.2 yr. Six, 3, 5, and 3 patients were diagnosed with acute myocardial infarction, cardiac arrest, septic shock, and acute respiratory distress syndrome, respectively. The mean dosage of nafamostat mesilate was 0.64 mg/kg/hr, and the mean duration of ECMO was 270.7 hr. The daily volume of transfused packed red blood cells, fresh frozen plasma, and cryoprecipitate and the number of complications related to hemorrhage and thrombosis was lower in the nafamostat mesilate group than in the heparin group. Nafamostat mesilate should be considered as an alternative anticoagulant to heparin to reduce bleeding complications during ECMO.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Han SJ,Kim HS,Kim KI,Whang SM,Hong KS,Lee WK,Lee SHdoi
10.3346/jkms.2011.26.7.945subject
Has Abstractpub_date
2011-07-01 00:00:00pages
945-50issue
7eissn
1011-8934issn
1598-6357journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Few studies have reported on breakthrough urinary tract infection (UTI) associated with the susceptibility of index UTI to prophylactic antibiotics in children with primary vesicoureteral reflux (VUR) receiving continuous antibiotic prophylaxis (CAP). We assessed the impact of the susceptibility of index UTI...
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journal_title:Journal of Korean medical science
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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